Gene expression profile analysis of primary glioblastomas and non-neoplastic brain tissue: identification of potential target genes by oligonucleotide microarray and ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-07

AUTHORS

Carlos A. Scrideli, Carlos G. Carlotti, Oswaldo K. Okamoto, Vanessa S. Andrade, Maria A. A. Cortez, Fábio J. N. Motta, Agda K. Lucio-Eterovic, Luciano Neder, Sérgio Rosemberg, Sueli M. Oba-Shinjo, Suely K. N. Marie, Luíz G. Tone

ABSTRACT

The prognosis of glioblastomas is still extremely poor and the discovery of novel molecular therapeutic targets can be important to optimize treatment strategies. Gene expression analyses comparing normal and neoplastic tissues have been used to identify genes associated with tumorigenesis and potential therapeutic targets. We have used this approach to identify differentially expressed genes between primary glioblastomas and non-neoplastic brain tissues. We selected 20 overexpressed genes related to cell cycle, cellular movement and growth, proliferation and cell-to-cell signaling and analyzed their expression levels by real time quantitative PCR in cDNA obtained from microdissected fresh tumor tissue from 20 patients with primary glioblastomas and from 10 samples of non-neoplastic white matter tissue. The gene expression levels were significantly higher in glioblastomas than in non-neoplastic white matter in 18 out of 20 genes analyzed: P < 0.00001 for CDKN2C, CKS2, EEF1A1, EMP3, PDPN, BNIP2, CA12, CD34, CDC42EP4, PPIE, SNAI2, GDF15 and MMP23b; and NFIA (P: 0.0001), GPS1 (P: 0.0003), LAMA1 (P: 0.002), STIM1 (P: 0.006), and TASP1 (P: 0.01). Five of these genes are located in contiguous loci at 1p31-36 and 2 at 17q24-25 and 8 of them encode surface membrane proteins. PDPN and CD34 protein expression were evaluated by immunohistochemistry and they showed concordance with the PCR results. The present results indicate the presence of 18 overexpressed genes in human primary glioblastomas that may play a significant role in the pathogenesis of these tumors and that deserve further functional investigation as attractive candidates for new therapeutic targets. More... »

PAGES

281-291

References to SciGraph publications

  • 1998-08. Co-amplification of a novel cyclophilin-like gene (PPIE) with L-myc in small cell lung cancer cell lines in ONCOGENE
  • 2002-04. A new family of cyclophilins with an RNA recognition motif that interact with members of the trx/MLL protein family in Drosophila and human cells in DEVELOPMENT GENES AND EVOLUTION
  • 2005-11. Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion in ONCOGENE
  • 2006-08. Angiogenic patterns and their quantitation in high grade astrocytic tumors in JOURNAL OF NEURO-ONCOLOGY
  • 2006-04. Podoplanin is expressed in subsets of tumors of the central nervous system in VIRCHOWS ARCHIV
  • 2006-12. Gene expressions and copy numbers associated with metastatic phenotypes of uterine cervical cancer in BMC GENOMICS
  • 2006-05. Tumor-associated carbonic anhydrases are linked to metastases in primary cervical cancer in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2005-12. Translation elongation factor eEF1A2 is a potential oncoprotein that is overexpressed in two-thirds of breast tumours in BMC CANCER
  • 2006-05. Increased expression of podoplanin in malignant astrocytic tumors as a novel molecular marker of malignant progression in ACTA NEUROPATHOLOGICA
  • 2003-06. BNips: A group of pro-apoptotic proteins in the Bcl-2 family in APOPTOSIS
  • 2004-10. DNA-microarray analysis of brain cancer: molecular classification for therapy in NATURE REVIEWS NEUROSCIENCE
  • 2006-06. Slug expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients in BRITISH JOURNAL OF CANCER
  • 2002-07. Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer in NATURE GENETICS
  • 2003-05. cDNA microarray analysis of genes associated with ERBB2 (HER2/neu) overexpression in human mammary luminal epithelial cells in ONCOGENE
  • 2007-01. The potential role of podoplanin in tumour invasion in BRITISH JOURNAL OF CANCER
  • 2003-04. Carbonic anhydrase XII is a marker of good prognosis in invasive breast carcinoma in BRITISH JOURNAL OF CANCER
  • 2007-07. Prognostic significance of co-overexpression of the EGFR/IGFBP-2/HIF-2A genes in astrocytomas in JOURNAL OF NEURO-ONCOLOGY
  • 1999-04. The CD34 epitope is expressed in neoplastic and malformative lesions associated with chronic, focal epilepsies in ACTA NEUROPATHOLOGICA
  • 2006-05. Genetically distinct and clinically relevant subtypes of glioblastoma defined by array-based comparative genomic hybridization (array-CGH) in ACTA NEUROPATHOLOGICA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11060-008-9579-4

    DOI

    http://dx.doi.org/10.1007/s11060-008-9579-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1023451130

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18398573


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