Knockdown of GluR1 expression by RNA interference inhibits glioma proliferation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-03-04

AUTHORS

John F. de Groot, Yuji Piao, Li Lu, Gregory N. Fuller, W. K. Alfred Yung

ABSTRACT

High-grade gliomas release excitotoxic concentrations of glutamate which contributes to their malignant phenotype. To improve our understanding of the mechanisms by which glutamate enhances tumor growth and invasion, we examined α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-mediated signaling in glioma cell lines. shRNA was used to stably knockdown GluR1, the most abundant AMPA receptor subunit in glioma, to evaluate its role in tumor signaling, proliferation and tumorigenicity. In a tissue array, there was a statistically significant increase in GluR1 expression in glioblastoma samples compared to anaplastic astrocytoma and low-grade tumors. In vitro, we observed a time and dose-dependent increase in MAPK phosphorylation following exposure to AMPA, which was blocked with AMPA receptor antagonists and the MEK1 inhibitor PD98059. Retroviral delivery of GluR1 shRNA in U251 and U87 glioma cells reduced GluR1 protein expression, inhibited AMPA-mediated increases in MAPK phosphorylation, and decreased glioma proliferation in vitro. U251 and U87 shGluR1 cells implanted into the flanks of nude mice grew slower than controls, which correlated with a decrease in proliferation measured by Ki-67 staining and an increase in apoptosis. These results suggest that AMPA receptors are abundantly expressed in high-grade gliomas and gene silencing of the GluR1 AMPA receptor subunit results in abrogation of AMPA-mediated signaling and tumor growth. More... »

PAGES

121-133

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11060-008-9552-2

DOI

http://dx.doi.org/10.1007/s11060-008-9552-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032937995

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18317690


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinogenicity Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glioma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ki-67 Antigen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Nude", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microarray Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA Interference", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Double-Stranded", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Small Interfering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, AMPA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Neuro-Oncology, Unit 431, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., 77030, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Brain Tumor Center, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA", 
            "Department of Neuro-Oncology, Unit 431, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Groot", 
        "givenName": "John F.", 
        "id": "sg:person.0662322764.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662322764.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Brain Tumor Center, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Brain Tumor Center, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Piao", 
        "givenName": "Yuji", 
        "id": "sg:person.01201163334.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201163334.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Brain Tumor Center, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Brain Tumor Center, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lu", 
        "givenName": "Li", 
        "id": "sg:person.0773313775.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773313775.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fuller", 
        "givenName": "Gregory N.", 
        "id": "sg:person.013732343337.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013732343337.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Brain Tumor Center, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Brain Tumor Center, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yung", 
        "givenName": "W. K. Alfred", 
        "id": "sg:person.016341673457.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016341673457.32"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1023/a:1022106910017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031799033", 
          "https://doi.org/10.1023/a:1022106910017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/16269", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002644120", 
          "https://doi.org/10.1038/16269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0901-1010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019138275", 
          "https://doi.org/10.1038/nm0901-1010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/25147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005432965", 
          "https://doi.org/10.1038/25147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1010657030494", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053679311", 
          "https://doi.org/10.1023/a:1010657030494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn1517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018843747", 
          "https://doi.org/10.1038/nrn1517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1006426917654", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043941882", 
          "https://doi.org/10.1023/a:1006426917654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth1104-163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037779564", 
          "https://doi.org/10.1038/nmeth1104-163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm746", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006592040", 
          "https://doi.org/10.1038/nm746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1023781114568", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005802135", 
          "https://doi.org/10.1023/a:1023781114568"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-03-04", 
    "datePublishedReg": "2008-03-04", 
    "description": "High-grade gliomas release excitotoxic concentrations of glutamate which contributes to their malignant phenotype. To improve our understanding of the mechanisms by which glutamate enhances tumor growth and invasion, we examined \u03b1-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-mediated signaling in glioma cell lines. shRNA was used to stably knockdown GluR1, the most abundant AMPA receptor subunit in glioma, to evaluate its role in tumor signaling, proliferation and tumorigenicity. In a tissue array, there was a statistically significant increase in GluR1 expression in glioblastoma samples compared to anaplastic astrocytoma and low-grade tumors. In\u00a0vitro, we observed a time and dose-dependent increase in MAPK phosphorylation following exposure to AMPA, which was blocked with AMPA receptor antagonists and the MEK1 inhibitor PD98059. Retroviral delivery of GluR1 shRNA in U251 and U87 glioma cells reduced GluR1 protein expression, inhibited AMPA-mediated increases in MAPK phosphorylation, and decreased glioma proliferation in\u00a0vitro. U251 and U87 shGluR1 cells implanted into the flanks of nude mice grew slower than controls, which correlated with a decrease in proliferation measured by Ki-67 staining and an increase in apoptosis. These results suggest that AMPA receptors are abundantly expressed in high-grade gliomas and gene silencing of the GluR1 AMPA receptor subunit results in abrogation of AMPA-mediated signaling and tumor growth.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s11060-008-9552-2", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1094205", 
        "issn": [
          "0167-594X", 
          "1573-7373"
        ], 
        "name": "Journal of Neuro-Oncology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "88"
      }
    ], 
    "keywords": [
      "high-grade gliomas", 
      "GluR1 expression", 
      "glioma proliferation", 
      "tumor growth", 
      "methylisoxazole-4-propionic acid", 
      "GluR1 protein expression", 
      "low-grade tumors", 
      "AMPA receptor antagonist", 
      "Ki-67 staining", 
      "dose-dependent increase", 
      "AMPA receptor subunits", 
      "MAPK phosphorylation", 
      "glioma cell lines", 
      "U87 glioma cells", 
      "excitotoxic concentrations", 
      "receptor antagonist", 
      "tumor signaling", 
      "anaplastic astrocytoma", 
      "AMPA receptors", 
      "nude mice", 
      "MEK1 inhibitor PD98059", 
      "receptor subunits", 
      "tissue arrays", 
      "glioma cells", 
      "malignant phenotype", 
      "protein expression", 
      "gliomas", 
      "AMPA", 
      "significant increase", 
      "cell lines", 
      "glioblastoma samples", 
      "inhibitor PD98059", 
      "proliferation", 
      "shRNA", 
      "U251", 
      "retroviral delivery", 
      "glutamate", 
      "signaling", 
      "RNA interference", 
      "expression", 
      "cells", 
      "GluR1", 
      "astrocytomas", 
      "antagonist", 
      "tumors", 
      "mice", 
      "phosphorylation", 
      "receptors", 
      "increase", 
      "tumorigenicity", 
      "staining", 
      "subunit results", 
      "abrogation", 
      "apoptosis", 
      "invasion", 
      "knockdown", 
      "gene silencing", 
      "exposure", 
      "PD98059", 
      "phenotype", 
      "delivery", 
      "decrease", 
      "control", 
      "silencing", 
      "role", 
      "concentration", 
      "acid", 
      "results", 
      "mechanism", 
      "growth", 
      "subunits", 
      "samples", 
      "lines", 
      "time", 
      "understanding", 
      "interference", 
      "flank", 
      "array", 
      "abundant AMPA receptor subunit", 
      "GluR1 shRNA", 
      "U87 shGluR1 cells", 
      "shGluR1 cells", 
      "GluR1 AMPA receptor subunit results", 
      "AMPA receptor subunit results", 
      "receptor subunit results", 
      "abrogation of AMPA"
    ], 
    "name": "Knockdown of GluR1 expression by RNA interference inhibits glioma proliferation", 
    "pagination": "121-133", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032937995"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11060-008-9552-2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18317690"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11060-008-9552-2", 
      "https://app.dimensions.ai/details/publication/pub.1032937995"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-11-01T18:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_457.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s11060-008-9552-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11060-008-9552-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11060-008-9552-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11060-008-9552-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11060-008-9552-2'


 

This table displays all metadata directly associated to this object as RDF triples.

300 TRIPLES      22 PREDICATES      142 URIs      123 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11060-008-9552-2 schema:about N0307517a26ad4308a9ed36bef061a4f1
2 N0566230a3d8849729bef8038fc64670e
3 N05c9fbc9c8f64986b4dec42c8d8c93aa
4 N1c45ec48bf464f9fa5ac8d4e7f0ba731
5 N34127a9a1fdf410f8a58a0516f906410
6 N4315418c47934dcb969f2ff8acee8e19
7 N44fcc5e785314daeb4468b118de615af
8 N5556ed0d6b1540c2a59128877d8873fc
9 N6f3093868ad14e77b78f79d403688135
10 N7056a42e182648d1a5bf900fae467121
11 N72358a2f1e824f878a5ed0acbf1bfec1
12 N7f018a5b40954257b6f60fb3984aae51
13 N8c93bafceeb74b0fa6bdb5f8bc0ca050
14 N9768d74dedae4282b100b66be1a0df4f
15 Na1e6e62179404de19c20524266f249cc
16 Nb23a79c153ea4ab198f3d6019dfed5d3
17 Nc01f641aeb9b4d5c85341c7ce7f1e246
18 Ndad07c86d8bd4f1d994c720b8407a7ab
19 Nf2cc1922cd5d45f0b349628c7df6a412
20 anzsrc-for:11
21 anzsrc-for:1109
22 anzsrc-for:1112
23 schema:author N5ebc2a99013e40cdbc98fdae8f3bb894
24 schema:citation sg:pub.10.1023/a:1006426917654
25 sg:pub.10.1023/a:1010657030494
26 sg:pub.10.1023/a:1022106910017
27 sg:pub.10.1023/a:1023781114568
28 sg:pub.10.1038/16269
29 sg:pub.10.1038/25147
30 sg:pub.10.1038/nm0901-1010
31 sg:pub.10.1038/nm746
32 sg:pub.10.1038/nmeth1104-163
33 sg:pub.10.1038/nrn1517
34 schema:datePublished 2008-03-04
35 schema:datePublishedReg 2008-03-04
36 schema:description High-grade gliomas release excitotoxic concentrations of glutamate which contributes to their malignant phenotype. To improve our understanding of the mechanisms by which glutamate enhances tumor growth and invasion, we examined α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-mediated signaling in glioma cell lines. shRNA was used to stably knockdown GluR1, the most abundant AMPA receptor subunit in glioma, to evaluate its role in tumor signaling, proliferation and tumorigenicity. In a tissue array, there was a statistically significant increase in GluR1 expression in glioblastoma samples compared to anaplastic astrocytoma and low-grade tumors. In vitro, we observed a time and dose-dependent increase in MAPK phosphorylation following exposure to AMPA, which was blocked with AMPA receptor antagonists and the MEK1 inhibitor PD98059. Retroviral delivery of GluR1 shRNA in U251 and U87 glioma cells reduced GluR1 protein expression, inhibited AMPA-mediated increases in MAPK phosphorylation, and decreased glioma proliferation in vitro. U251 and U87 shGluR1 cells implanted into the flanks of nude mice grew slower than controls, which correlated with a decrease in proliferation measured by Ki-67 staining and an increase in apoptosis. These results suggest that AMPA receptors are abundantly expressed in high-grade gliomas and gene silencing of the GluR1 AMPA receptor subunit results in abrogation of AMPA-mediated signaling and tumor growth.
37 schema:genre article
38 schema:inLanguage en
39 schema:isAccessibleForFree false
40 schema:isPartOf Nb1c84630f1ee4c7483df65ae64aec473
41 Nc0bde0ca76024a09bfbdf514bc1762cb
42 sg:journal.1094205
43 schema:keywords AMPA
44 AMPA receptor antagonist
45 AMPA receptor subunit results
46 AMPA receptor subunits
47 AMPA receptors
48 GluR1
49 GluR1 AMPA receptor subunit results
50 GluR1 expression
51 GluR1 protein expression
52 GluR1 shRNA
53 Ki-67 staining
54 MAPK phosphorylation
55 MEK1 inhibitor PD98059
56 PD98059
57 RNA interference
58 U251
59 U87 glioma cells
60 U87 shGluR1 cells
61 abrogation
62 abrogation of AMPA
63 abundant AMPA receptor subunit
64 acid
65 anaplastic astrocytoma
66 antagonist
67 apoptosis
68 array
69 astrocytomas
70 cell lines
71 cells
72 concentration
73 control
74 decrease
75 delivery
76 dose-dependent increase
77 excitotoxic concentrations
78 exposure
79 expression
80 flank
81 gene silencing
82 glioblastoma samples
83 glioma cell lines
84 glioma cells
85 glioma proliferation
86 gliomas
87 glutamate
88 growth
89 high-grade gliomas
90 increase
91 inhibitor PD98059
92 interference
93 invasion
94 knockdown
95 lines
96 low-grade tumors
97 malignant phenotype
98 mechanism
99 methylisoxazole-4-propionic acid
100 mice
101 nude mice
102 phenotype
103 phosphorylation
104 proliferation
105 protein expression
106 receptor antagonist
107 receptor subunit results
108 receptor subunits
109 receptors
110 results
111 retroviral delivery
112 role
113 samples
114 shGluR1 cells
115 shRNA
116 signaling
117 significant increase
118 silencing
119 staining
120 subunit results
121 subunits
122 time
123 tissue arrays
124 tumor growth
125 tumor signaling
126 tumorigenicity
127 tumors
128 understanding
129 schema:name Knockdown of GluR1 expression by RNA interference inhibits glioma proliferation
130 schema:pagination 121-133
131 schema:productId N353c666a14824a01bbcee7d42999c2eb
132 N5bc4efc8e57743e8bb92f22d08a8ca06
133 Nb5005ad654fd4d2bbabab043a7f9e6de
134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032937995
135 https://doi.org/10.1007/s11060-008-9552-2
136 schema:sdDatePublished 2021-11-01T18:11
137 schema:sdLicense https://scigraph.springernature.com/explorer/license/
138 schema:sdPublisher Nf0576fa5824643d19698c8af73db888c
139 schema:url https://doi.org/10.1007/s11060-008-9552-2
140 sgo:license sg:explorer/license/
141 sgo:sdDataset articles
142 rdf:type schema:ScholarlyArticle
143 N0307517a26ad4308a9ed36bef061a4f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Gene Expression Regulation
145 rdf:type schema:DefinedTerm
146 N052d07301c77439ab639630597648859 rdf:first sg:person.0773313775.09
147 rdf:rest Na84c47edea2c459d9f33bf9d500b8e5d
148 N0566230a3d8849729bef8038fc64670e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Cell Line, Tumor
150 rdf:type schema:DefinedTerm
151 N05c9fbc9c8f64986b4dec42c8d8c93aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Glioma
153 rdf:type schema:DefinedTerm
154 N1c45ec48bf464f9fa5ac8d4e7f0ba731 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Mice, Nude
156 rdf:type schema:DefinedTerm
157 N305efc9946444e2d8b16ce8c79b083a6 rdf:first sg:person.016341673457.32
158 rdf:rest rdf:nil
159 N34127a9a1fdf410f8a58a0516f906410 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Cell Cycle
161 rdf:type schema:DefinedTerm
162 N353c666a14824a01bbcee7d42999c2eb schema:name pubmed_id
163 schema:value 18317690
164 rdf:type schema:PropertyValue
165 N4315418c47934dcb969f2ff8acee8e19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Animals
167 rdf:type schema:DefinedTerm
168 N44fcc5e785314daeb4468b118de615af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Brain Neoplasms
170 rdf:type schema:DefinedTerm
171 N5556ed0d6b1540c2a59128877d8873fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Mice
173 rdf:type schema:DefinedTerm
174 N5bc4efc8e57743e8bb92f22d08a8ca06 schema:name dimensions_id
175 schema:value pub.1032937995
176 rdf:type schema:PropertyValue
177 N5ebc2a99013e40cdbc98fdae8f3bb894 rdf:first sg:person.0662322764.76
178 rdf:rest N7b3f294c2d22461fabf0556edc107cc7
179 N6f3093868ad14e77b78f79d403688135 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Ki-67 Antigen
181 rdf:type schema:DefinedTerm
182 N7056a42e182648d1a5bf900fae467121 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Microarray Analysis
184 rdf:type schema:DefinedTerm
185 N72358a2f1e824f878a5ed0acbf1bfec1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name RNA, Double-Stranded
187 rdf:type schema:DefinedTerm
188 N7b3f294c2d22461fabf0556edc107cc7 rdf:first sg:person.01201163334.77
189 rdf:rest N052d07301c77439ab639630597648859
190 N7f018a5b40954257b6f60fb3984aae51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name RNA Interference
192 rdf:type schema:DefinedTerm
193 N8c93bafceeb74b0fa6bdb5f8bc0ca050 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Humans
195 rdf:type schema:DefinedTerm
196 N9768d74dedae4282b100b66be1a0df4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Down-Regulation
198 rdf:type schema:DefinedTerm
199 Na1e6e62179404de19c20524266f249cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Signal Transduction
201 rdf:type schema:DefinedTerm
202 Na84c47edea2c459d9f33bf9d500b8e5d rdf:first sg:person.013732343337.08
203 rdf:rest N305efc9946444e2d8b16ce8c79b083a6
204 Nb1c84630f1ee4c7483df65ae64aec473 schema:issueNumber 2
205 rdf:type schema:PublicationIssue
206 Nb23a79c153ea4ab198f3d6019dfed5d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Receptors, AMPA
208 rdf:type schema:DefinedTerm
209 Nb5005ad654fd4d2bbabab043a7f9e6de schema:name doi
210 schema:value 10.1007/s11060-008-9552-2
211 rdf:type schema:PropertyValue
212 Nc01f641aeb9b4d5c85341c7ce7f1e246 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
213 schema:name RNA, Small Interfering
214 rdf:type schema:DefinedTerm
215 Nc0bde0ca76024a09bfbdf514bc1762cb schema:volumeNumber 88
216 rdf:type schema:PublicationVolume
217 Ndad07c86d8bd4f1d994c720b8407a7ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
218 schema:name Cell Proliferation
219 rdf:type schema:DefinedTerm
220 Nf0576fa5824643d19698c8af73db888c schema:name Springer Nature - SN SciGraph project
221 rdf:type schema:Organization
222 Nf2cc1922cd5d45f0b349628c7df6a412 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
223 schema:name Carcinogenicity Tests
224 rdf:type schema:DefinedTerm
225 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
226 schema:name Medical and Health Sciences
227 rdf:type schema:DefinedTerm
228 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
229 schema:name Neurosciences
230 rdf:type schema:DefinedTerm
231 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
232 schema:name Oncology and Carcinogenesis
233 rdf:type schema:DefinedTerm
234 sg:journal.1094205 schema:issn 0167-594X
235 1573-7373
236 schema:name Journal of Neuro-Oncology
237 schema:publisher Springer Nature
238 rdf:type schema:Periodical
239 sg:person.01201163334.77 schema:affiliation grid-institutes:grid.240145.6
240 schema:familyName Piao
241 schema:givenName Yuji
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201163334.77
243 rdf:type schema:Person
244 sg:person.013732343337.08 schema:affiliation grid-institutes:grid.240145.6
245 schema:familyName Fuller
246 schema:givenName Gregory N.
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013732343337.08
248 rdf:type schema:Person
249 sg:person.016341673457.32 schema:affiliation grid-institutes:grid.240145.6
250 schema:familyName Yung
251 schema:givenName W. K. Alfred
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016341673457.32
253 rdf:type schema:Person
254 sg:person.0662322764.76 schema:affiliation grid-institutes:grid.240145.6
255 schema:familyName de Groot
256 schema:givenName John F.
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662322764.76
258 rdf:type schema:Person
259 sg:person.0773313775.09 schema:affiliation grid-institutes:grid.240145.6
260 schema:familyName Lu
261 schema:givenName Li
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773313775.09
263 rdf:type schema:Person
264 sg:pub.10.1023/a:1006426917654 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043941882
265 https://doi.org/10.1023/a:1006426917654
266 rdf:type schema:CreativeWork
267 sg:pub.10.1023/a:1010657030494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053679311
268 https://doi.org/10.1023/a:1010657030494
269 rdf:type schema:CreativeWork
270 sg:pub.10.1023/a:1022106910017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031799033
271 https://doi.org/10.1023/a:1022106910017
272 rdf:type schema:CreativeWork
273 sg:pub.10.1023/a:1023781114568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005802135
274 https://doi.org/10.1023/a:1023781114568
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/16269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002644120
277 https://doi.org/10.1038/16269
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/25147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005432965
280 https://doi.org/10.1038/25147
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/nm0901-1010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019138275
283 https://doi.org/10.1038/nm0901-1010
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/nm746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006592040
286 https://doi.org/10.1038/nm746
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/nmeth1104-163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037779564
289 https://doi.org/10.1038/nmeth1104-163
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/nrn1517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018843747
292 https://doi.org/10.1038/nrn1517
293 rdf:type schema:CreativeWork
294 grid-institutes:grid.240145.6 schema:alternateName Brain Tumor Center, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
295 Department of Neuro-Oncology, Unit 431, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., 77030, Houston, TX, USA
296 Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
297 schema:name Brain Tumor Center, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
298 Department of Neuro-Oncology, Unit 431, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., 77030, Houston, TX, USA
299 Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
300 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...