Localization of α-Synuclein in the Rat Brain and Its Relationship with Dopaminergic Structures View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-11

AUTHORS

D. N. Voronkov, R. M. Khudoerkov, O. V. Sal’nikova, V. B. Sobolev

ABSTRACT

Immunocytochemical studies of the brain in intact Wistar rats (n = 5) addressed the localization of α-synuclein (α-Syn), which is a protein presented in Lewy bodies in Parkinson’s disease (PD), and tyrosine hydroxylase, a marker of dopaminergic and noradrenergic neurons, in comparison with data obtained after lesioning of the substantia nigra (n = 3). The localization of α-Syn in synaptic structures in the basal nuclei corresponded to corticostriate and strionigral projections, which was confirmed experimentally. The bodies of dopaminergic and noradrenergic neurons in the substantia nigra, locus ceruleus, and dorsal nucleus of the vagus nerve were found to contain α-Syn – these are structures which undergo neurodegeneration in PD. Sensory olfactory neurons and glomeruli in the olfactory bulbs also had high α-Syn contents. More... »

PAGES

1147-1152

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11055-017-0522-z

DOI

http://dx.doi.org/10.1007/s11055-017-0522-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092749397


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Scientific Center", 
          "id": "https://www.grid.ac/institutes/grid.465407.4", 
          "name": [
            "Functional Morphochemistry Laboratory, Department of Brain Research, Neurology Scientific Center, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Voronkov", 
        "givenName": "D. N.", 
        "id": "sg:person.01324665446.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324665446.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Scientific Center", 
          "id": "https://www.grid.ac/institutes/grid.465407.4", 
          "name": [
            "Functional Morphochemistry Laboratory, Department of Brain Research, Neurology Scientific Center, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Khudoerkov", 
        "givenName": "R. M.", 
        "id": "sg:person.071130541.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.071130541.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Scientific Center", 
          "id": "https://www.grid.ac/institutes/grid.465407.4", 
          "name": [
            "Functional Morphochemistry Laboratory, Department of Brain Research, Neurology Scientific Center, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sal\u2019nikova", 
        "givenName": "O. V.", 
        "id": "sg:person.0723543240.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723543240.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Scientific Center", 
          "id": "https://www.grid.ac/institutes/grid.465407.4", 
          "name": [
            "Functional Morphochemistry Laboratory, Department of Brain Research, Neurology Scientific Center, Moscow, Russia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sobolev", 
        "givenName": "V. B.", 
        "id": "sg:person.0771656440.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771656440.15"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.bbadis.2011.10.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006855634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.22464", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010245797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.22464", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010245797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0306-4522(02)00143-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011000110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1353-8020(13)70022-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014344490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00429-013-0651-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018709110", 
          "https://doi.org/10.1007/s00429-013-0651-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/exnr.1999.7228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020690479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/nan.12298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023467822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00702-015-1405-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030998936", 
          "https://doi.org/10.1007/s00702-015-1405-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semcdb.2012.09.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032682867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.23901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033358513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jchemneu.2010.12.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037399929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-012-1062-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037798309", 
          "https://doi.org/10.1007/s00018-012-1062-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-015-1451-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039505039", 
          "https://doi.org/10.1007/s00401-015-1451-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-011-0830-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045348226", 
          "https://doi.org/10.1007/s00401-011-0830-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-016-1538-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051680013", 
          "https://doi.org/10.1007/s00401-016-1538-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-016-1538-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051680013", 
          "https://doi.org/10.1007/s00401-016-1538-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-8993(02)02643-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053716641"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-11", 
    "datePublishedReg": "2017-11-01", 
    "description": "Immunocytochemical studies of the brain in intact Wistar rats (n = 5) addressed the localization of \u03b1-synuclein (\u03b1-Syn), which is a protein presented in Lewy bodies in Parkinson\u2019s disease (PD), and tyrosine hydroxylase, a marker of dopaminergic and noradrenergic neurons, in comparison with data obtained after lesioning of the substantia nigra (n = 3). The localization of \u03b1-Syn in synaptic structures in the basal nuclei corresponded to corticostriate and strionigral projections, which was confirmed experimentally. The bodies of dopaminergic and noradrenergic neurons in the substantia nigra, locus ceruleus, and dorsal nucleus of the vagus nerve were found to contain \u03b1-Syn \u2013 these are structures which undergo neurodegeneration in PD. Sensory olfactory neurons and glomeruli in the olfactory bulbs also had high \u03b1-Syn contents.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11055-017-0522-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1015474", 
        "issn": [
          "0097-0549", 
          "1573-899X"
        ], 
        "name": "Neuroscience and Behavioral Physiology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "47"
      }
    ], 
    "name": "Localization of \u03b1-Synuclein in the Rat Brain and Its Relationship with Dopaminergic Structures", 
    "pagination": "1147-1152", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "15c215decab6d135567c2c047effc14452c9afd3d35a9cc8aa4d07188c6e9fc3"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11055-017-0522-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1092749397"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11055-017-0522-z", 
      "https://app.dimensions.ai/details/publication/pub.1092749397"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:18", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000484.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s11055-017-0522-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11055-017-0522-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11055-017-0522-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11055-017-0522-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11055-017-0522-z'


 

This table displays all metadata directly associated to this object as RDF triples.

136 TRIPLES      21 PREDICATES      43 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11055-017-0522-z schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author Na80f6fc3afdc4851a6debd64283231b6
4 schema:citation sg:pub.10.1007/s00018-012-1062-x
5 sg:pub.10.1007/s00401-011-0830-2
6 sg:pub.10.1007/s00401-015-1451-y
7 sg:pub.10.1007/s00401-016-1538-0
8 sg:pub.10.1007/s00429-013-0651-2
9 sg:pub.10.1007/s00702-015-1405-5
10 https://doi.org/10.1002/cne.23901
11 https://doi.org/10.1002/mds.22464
12 https://doi.org/10.1006/exnr.1999.7228
13 https://doi.org/10.1016/j.bbadis.2011.10.002
14 https://doi.org/10.1016/j.jchemneu.2010.12.003
15 https://doi.org/10.1016/j.semcdb.2012.09.001
16 https://doi.org/10.1016/s0006-8993(02)02643-4
17 https://doi.org/10.1016/s0306-4522(02)00143-4
18 https://doi.org/10.1016/s1353-8020(13)70022-1
19 https://doi.org/10.1111/nan.12298
20 schema:datePublished 2017-11
21 schema:datePublishedReg 2017-11-01
22 schema:description Immunocytochemical studies of the brain in intact Wistar rats (n = 5) addressed the localization of α-synuclein (α-Syn), which is a protein presented in Lewy bodies in Parkinson’s disease (PD), and tyrosine hydroxylase, a marker of dopaminergic and noradrenergic neurons, in comparison with data obtained after lesioning of the substantia nigra (n = 3). The localization of α-Syn in synaptic structures in the basal nuclei corresponded to corticostriate and strionigral projections, which was confirmed experimentally. The bodies of dopaminergic and noradrenergic neurons in the substantia nigra, locus ceruleus, and dorsal nucleus of the vagus nerve were found to contain α-Syn – these are structures which undergo neurodegeneration in PD. Sensory olfactory neurons and glomeruli in the olfactory bulbs also had high α-Syn contents.
23 schema:genre research_article
24 schema:inLanguage en
25 schema:isAccessibleForFree false
26 schema:isPartOf N18ffaeed788a4583bea4c9ea88641a65
27 N416dc486c79f4a80a1d969561ea3cc6e
28 sg:journal.1015474
29 schema:name Localization of α-Synuclein in the Rat Brain and Its Relationship with Dopaminergic Structures
30 schema:pagination 1147-1152
31 schema:productId N191468f1542844d2b9f89cad90c284e9
32 Ne2be036f97974c24a6be248ca0fe4ab7
33 Nf1fe31ca3ce94b0697ab6aad6ae6afa0
34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092749397
35 https://doi.org/10.1007/s11055-017-0522-z
36 schema:sdDatePublished 2019-04-10T23:18
37 schema:sdLicense https://scigraph.springernature.com/explorer/license/
38 schema:sdPublisher N8fdff60af7d443efb9ace6c782d9af70
39 schema:url http://link.springer.com/10.1007/s11055-017-0522-z
40 sgo:license sg:explorer/license/
41 sgo:sdDataset articles
42 rdf:type schema:ScholarlyArticle
43 N18ffaeed788a4583bea4c9ea88641a65 schema:volumeNumber 47
44 rdf:type schema:PublicationVolume
45 N191468f1542844d2b9f89cad90c284e9 schema:name readcube_id
46 schema:value 15c215decab6d135567c2c047effc14452c9afd3d35a9cc8aa4d07188c6e9fc3
47 rdf:type schema:PropertyValue
48 N27604f2d1e2e45c7a4c625b84b49eebe rdf:first sg:person.0771656440.15
49 rdf:rest rdf:nil
50 N416dc486c79f4a80a1d969561ea3cc6e schema:issueNumber 9
51 rdf:type schema:PublicationIssue
52 N48d1cae79f3144bd997b79d62a2ef715 rdf:first sg:person.071130541.25
53 rdf:rest N8a893c0db79247db996361b196ed5354
54 N8a893c0db79247db996361b196ed5354 rdf:first sg:person.0723543240.54
55 rdf:rest N27604f2d1e2e45c7a4c625b84b49eebe
56 N8fdff60af7d443efb9ace6c782d9af70 schema:name Springer Nature - SN SciGraph project
57 rdf:type schema:Organization
58 Na80f6fc3afdc4851a6debd64283231b6 rdf:first sg:person.01324665446.15
59 rdf:rest N48d1cae79f3144bd997b79d62a2ef715
60 Ne2be036f97974c24a6be248ca0fe4ab7 schema:name dimensions_id
61 schema:value pub.1092749397
62 rdf:type schema:PropertyValue
63 Nf1fe31ca3ce94b0697ab6aad6ae6afa0 schema:name doi
64 schema:value 10.1007/s11055-017-0522-z
65 rdf:type schema:PropertyValue
66 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
67 schema:name Medical and Health Sciences
68 rdf:type schema:DefinedTerm
69 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
70 schema:name Neurosciences
71 rdf:type schema:DefinedTerm
72 sg:journal.1015474 schema:issn 0097-0549
73 1573-899X
74 schema:name Neuroscience and Behavioral Physiology
75 rdf:type schema:Periodical
76 sg:person.01324665446.15 schema:affiliation https://www.grid.ac/institutes/grid.465407.4
77 schema:familyName Voronkov
78 schema:givenName D. N.
79 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324665446.15
80 rdf:type schema:Person
81 sg:person.071130541.25 schema:affiliation https://www.grid.ac/institutes/grid.465407.4
82 schema:familyName Khudoerkov
83 schema:givenName R. M.
84 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.071130541.25
85 rdf:type schema:Person
86 sg:person.0723543240.54 schema:affiliation https://www.grid.ac/institutes/grid.465407.4
87 schema:familyName Sal’nikova
88 schema:givenName O. V.
89 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723543240.54
90 rdf:type schema:Person
91 sg:person.0771656440.15 schema:affiliation https://www.grid.ac/institutes/grid.465407.4
92 schema:familyName Sobolev
93 schema:givenName V. B.
94 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771656440.15
95 rdf:type schema:Person
96 sg:pub.10.1007/s00018-012-1062-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037798309
97 https://doi.org/10.1007/s00018-012-1062-x
98 rdf:type schema:CreativeWork
99 sg:pub.10.1007/s00401-011-0830-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045348226
100 https://doi.org/10.1007/s00401-011-0830-2
101 rdf:type schema:CreativeWork
102 sg:pub.10.1007/s00401-015-1451-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1039505039
103 https://doi.org/10.1007/s00401-015-1451-y
104 rdf:type schema:CreativeWork
105 sg:pub.10.1007/s00401-016-1538-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051680013
106 https://doi.org/10.1007/s00401-016-1538-0
107 rdf:type schema:CreativeWork
108 sg:pub.10.1007/s00429-013-0651-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018709110
109 https://doi.org/10.1007/s00429-013-0651-2
110 rdf:type schema:CreativeWork
111 sg:pub.10.1007/s00702-015-1405-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030998936
112 https://doi.org/10.1007/s00702-015-1405-5
113 rdf:type schema:CreativeWork
114 https://doi.org/10.1002/cne.23901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033358513
115 rdf:type schema:CreativeWork
116 https://doi.org/10.1002/mds.22464 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010245797
117 rdf:type schema:CreativeWork
118 https://doi.org/10.1006/exnr.1999.7228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020690479
119 rdf:type schema:CreativeWork
120 https://doi.org/10.1016/j.bbadis.2011.10.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006855634
121 rdf:type schema:CreativeWork
122 https://doi.org/10.1016/j.jchemneu.2010.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037399929
123 rdf:type schema:CreativeWork
124 https://doi.org/10.1016/j.semcdb.2012.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032682867
125 rdf:type schema:CreativeWork
126 https://doi.org/10.1016/s0006-8993(02)02643-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053716641
127 rdf:type schema:CreativeWork
128 https://doi.org/10.1016/s0306-4522(02)00143-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011000110
129 rdf:type schema:CreativeWork
130 https://doi.org/10.1016/s1353-8020(13)70022-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014344490
131 rdf:type schema:CreativeWork
132 https://doi.org/10.1111/nan.12298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023467822
133 rdf:type schema:CreativeWork
134 https://www.grid.ac/institutes/grid.465407.4 schema:alternateName Scientific Center
135 schema:name Functional Morphochemistry Laboratory, Department of Brain Research, Neurology Scientific Center, Moscow, Russia
136 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...