Changes in Neuroglial Interactions in Nigrostriatal Brain Structures on Modeling of Dopamine System Dysfunction View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-11

AUTHORS

D. N. Voronkov, R. M. Khudoerkov, E. L. Dovedova

ABSTRACT

Hypofunction of the dopamine system was induced by prolonged administration of reserpine or haloperidol in Wistar rats. Reserpine increased the number of astrocytes containing glial fibrillary acidic protein in the striatum by 49%, but decreased the number of astrocytes containing glutamine synthase by 23% and reduced monoamine oxidase B activity by one third. Haloperidol had no significant effect on morphochemical measures of astrocytes but increased the number of oligodendrocytes. It is suggested that activation of astroglial cells by reserpine in a model of dopamine hypofunction is induced by metabolic impairment in the corticostriate glutamatergic system resulting from suppression of dopaminergic transmission in the basal nuclei. Changes in neuroglial interactions in the striatum, leading to imbalance of neurotransmitter systems, may underlie dysfunction of the basal nuclei in a number of human diseases, including Parkinson’s disease. More... »

PAGES

1073-1077

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11055-014-0027-y

DOI

http://dx.doi.org/10.1007/s11055-014-0027-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013251031


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