Zinc protects the rat brain from damage induced by 24 h exposure to silver nanoparticles View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-08-05

AUTHORS

Samuel Salazar-García, Norma Laura Delgado-Buenrostro, Juan Carlos Rodríguez-Escamilla, Guillermo Davalos-Rivas, Yolanda Irasema Chirino, Claudia G. Castillo Martín del Campo, Gabriel A. Martínez-Castañón, Juan Manuel Vargas-Morales, Carmen Gonzalez

ABSTRACT

Silver nanoparticles (AgNPs) have been widely employed due to their antimicrobial properties; however, several studies sustain that AgNPs can induce brain damage, like the blood–brain barrier (BBB) disruption. Among the BBB defense mechanisms, the metallothioneins (MTs), a collection of proteins that regulate intracellular levels of zinc (Zn), play an important role. The goal of this work was to investigate whether the brain damage caused by an intraperitoneal administration of AgNPs (15 mg/ g body weight) at the level of the BBB permeability disruption, damage of the brain tissue, and systemic inflammation could be prevented by 24 h of previous treatment with Zn (27 mg/kg body weight). Evans blue (EB) extravasation, modification of claudin-5 expression, alterations on MTs, N-cadherin expression, and systemic inflammation were evaluated. Our results show that AgNPs induce BBB damage by increasing EB extravasation and decreasing claudin-5 expression, associated with overexpression of MTs, effects that were related with systemic inflammation, evidenced by the increase of granulocytes. Zn pretreatment partially prevented the BBB permeability from the damage induced by AgNPs, whereas the MTs expression and granulocytes count exhibited a reversal effect, suggesting that the effect of Zn could be related with the BBB regulation process. The rat brain histological analysis confirmed that pretreatment with Zn prevented at least in part the toxic effect of AgNPs. This work provides relevant information about the role of Zn as a protectant against the noxious effects of AgNPs upon the rat brain physiology. More... »

PAGES

172

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11051-019-4616-0

DOI

http://dx.doi.org/10.1007/s11051-019-4616-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1120144504


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/02", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Physical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/09", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Engineering", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Technology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0202", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Atomic, Molecular, Nuclear, Particle and Plasma Physics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0912", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Materials Engineering", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1007", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Nanotechnology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Centro de Investigacion en Ciencias de la Salud y Biomedicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.412862.b", 
          "name": [
            "Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Av. Manuel Nava No. 6., Col. Universitaria, 78210, San Luis Potosi, Mexico", 
            "Centro de Investigacion en Ciencias de la Salud y Biomedicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salazar-Garc\u00eda", 
        "givenName": "Samuel", 
        "id": "sg:person.0714161226.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714161226.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de Mexico, Avenida de los Barrios No.1, Col. Los Reyes Iztacala, Tlalnepantla de Baz. CP 54059, Estado de Mexico, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.9486.3", 
          "name": [
            "Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de Mexico, Avenida de los Barrios No.1, Col. Los Reyes Iztacala, Tlalnepantla de Baz. CP 54059, Estado de Mexico, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Delgado-Buenrostro", 
        "givenName": "Norma Laura", 
        "id": "sg:person.01115757642.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115757642.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de Mexico, Avenida de los Barrios No.1, Col. Los Reyes Iztacala, Tlalnepantla de Baz. CP 54059, Estado de Mexico, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.9486.3", 
          "name": [
            "Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de Mexico, Avenida de los Barrios No.1, Col. Los Reyes Iztacala, Tlalnepantla de Baz. CP 54059, Estado de Mexico, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rodr\u00edguez-Escamilla", 
        "givenName": "Juan Carlos", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centro de Investigacion en Ciencias de la Salud y Biomedicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.412862.b", 
          "name": [
            "Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Av. Manuel Nava No. 6., Col. Universitaria, 78210, San Luis Potosi, Mexico", 
            "Centro de Investigacion en Ciencias de la Salud y Biomedicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Davalos-Rivas", 
        "givenName": "Guillermo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de Mexico, Avenida de los Barrios No.1, Col. Los Reyes Iztacala, Tlalnepantla de Baz. CP 54059, Estado de Mexico, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.9486.3", 
          "name": [
            "Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de Mexico, Avenida de los Barrios No.1, Col. Los Reyes Iztacala, Tlalnepantla de Baz. CP 54059, Estado de Mexico, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chirino", 
        "givenName": "Yolanda Irasema", 
        "id": "sg:person.01170625340.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170625340.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Facultad de Medicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.412862.b", 
          "name": [
            "Facultad de Medicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Castillo Mart\u00edn del Campo", 
        "givenName": "Claudia G.", 
        "id": "sg:person.010075535033.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010075535033.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Facultad de Estomatologia, Universidad Aut\u00f3noma de San Luis Potosi, San Luis Potosi, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.412862.b", 
          "name": [
            "Facultad de Estomatologia, Universidad Aut\u00f3noma de San Luis Potosi, San Luis Potosi, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mart\u00ednez-Casta\u00f1\u00f3n", 
        "givenName": "Gabriel A.", 
        "id": "sg:person.07536377517.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07536377517.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Av. Manuel Nava No. 6., Col. Universitaria, 78210, San Luis Potosi, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.412862.b", 
          "name": [
            "Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Av. Manuel Nava No. 6., Col. Universitaria, 78210, San Luis Potosi, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vargas-Morales", 
        "givenName": "Juan Manuel", 
        "id": "sg:person.0626613004.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626613004.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centro de Investigacion en Ciencias de la Salud y Biomedicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.412862.b", 
          "name": [
            "Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Av. Manuel Nava No. 6., Col. Universitaria, 78210, San Luis Potosi, Mexico", 
            "Centro de Investigacion en Ciencias de la Salud y Biomedicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gonzalez", 
        "givenName": "Carmen", 
        "id": "sg:person.01330146671.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330146671.61"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/1471-2121-10-65", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014834595", 
          "https://doi.org/10.1186/1471-2121-10-65"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00204-014-1447-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022485352", 
          "https://doi.org/10.1007/s00204-014-1447-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11051-013-1702-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046605799", 
          "https://doi.org/10.1007/s11051-013-1702-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11064-012-0767-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012938048", 
          "https://doi.org/10.1007/s11064-012-0767-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11064-017-2353-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090943008", 
          "https://doi.org/10.1007/s11064-017-2353-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10930-017-9737-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091388677", 
          "https://doi.org/10.1007/s10930-017-9737-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12868-018-0429-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103879218", 
          "https://doi.org/10.1186/s12868-018-0429-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-002-8454-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046374327", 
          "https://doi.org/10.1007/s00018-002-8454-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1743-8977-11-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047359255", 
          "https://doi.org/10.1186/1743-8977-11-11"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11051-015-3257-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052731922", 
          "https://doi.org/10.1007/s11051-015-3257-1"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-08-05", 
    "datePublishedReg": "2019-08-05", 
    "description": "Silver nanoparticles (AgNPs) have been widely employed due to their antimicrobial properties; however, several studies sustain that AgNPs can induce brain damage, like the blood\u2013brain barrier (BBB) disruption. Among the BBB defense mechanisms, the metallothioneins (MTs), a collection of proteins that regulate intracellular levels of zinc (Zn), play an important role. The goal of this work was to investigate whether the brain damage caused by an intraperitoneal administration of AgNPs (15\u00a0mg/ g body weight) at the level of the BBB permeability disruption, damage of the brain tissue, and systemic inflammation could be prevented by 24\u00a0h of previous treatment with Zn (27\u00a0mg/kg body weight). Evans blue (EB) extravasation, modification of claudin-5 expression, alterations on MTs, N-cadherin expression, and systemic inflammation were evaluated. Our results show that AgNPs induce BBB damage by increasing EB extravasation and decreasing claudin-5 expression, associated with overexpression of MTs, effects that were related with systemic inflammation, evidenced by the increase of granulocytes. Zn pretreatment partially prevented the BBB permeability from the damage induced by AgNPs, whereas the MTs expression and granulocytes count exhibited a reversal effect, suggesting that the effect of Zn could be related with the BBB regulation process. The rat brain histological analysis confirmed that pretreatment with Zn prevented at least in part the toxic effect of AgNPs. This work provides relevant information about the role of Zn as a protectant against the noxious effects of AgNPs upon the rat brain physiology.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s11051-019-4616-0", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1028317", 
        "issn": [
          "1388-0764", 
          "1572-896X"
        ], 
        "name": "Journal of Nanoparticle Research", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "keywords": [
      "systemic inflammation", 
      "claudin-5 expression", 
      "brain damage", 
      "blood-brain barrier disruption", 
      "brain histological analysis", 
      "Evans blue extravasation", 
      "increase of granulocytes", 
      "overexpression of metallothionein", 
      "MTs expression", 
      "BBB damage", 
      "EB extravasation", 
      "BBB permeability", 
      "barrier disruption", 
      "granulocyte count", 
      "intraperitoneal administration", 
      "Zn pretreatment", 
      "rat brain", 
      "N-cadherin expression", 
      "permeability disruption", 
      "brain tissue", 
      "brain physiology", 
      "inflammation", 
      "histological analysis", 
      "previous treatment", 
      "noxious effects", 
      "intracellular levels", 
      "extravasation", 
      "toxic effects", 
      "h exposure", 
      "reversal effect", 
      "defense mechanisms", 
      "expression", 
      "damage", 
      "role of Zn", 
      "metallothionein", 
      "pretreatment", 
      "administration", 
      "granulocytes", 
      "brain", 
      "disruption", 
      "important role", 
      "effect", 
      "levels", 
      "treatment", 
      "tissue", 
      "alterations", 
      "role", 
      "exposure", 
      "overexpression", 
      "count", 
      "physiology", 
      "relevant information", 
      "antimicrobial properties", 
      "protein", 
      "study", 
      "increase", 
      "zinc", 
      "protectants", 
      "effect of Zn", 
      "mechanism", 
      "regulation processes", 
      "permeability", 
      "analysis", 
      "results", 
      "goal", 
      "modification", 
      "collection", 
      "part", 
      "information", 
      "collection of proteins", 
      "work", 
      "process", 
      "AgNPs", 
      "Zn", 
      "properties", 
      "silver nanoparticles", 
      "nanoparticles"
    ], 
    "name": "Zinc protects the rat brain from damage induced by 24 h exposure to silver nanoparticles", 
    "pagination": "172", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1120144504"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11051-019-4616-0"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11051-019-4616-0", 
      "https://app.dimensions.ai/details/publication/pub.1120144504"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T17:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_821.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s11051-019-4616-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11051-019-4616-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11051-019-4616-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11051-019-4616-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11051-019-4616-0'


 

This table displays all metadata directly associated to this object as RDF triples.

253 TRIPLES      21 PREDICATES      115 URIs      93 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11051-019-4616-0 schema:about anzsrc-for:02
2 anzsrc-for:0202
3 anzsrc-for:09
4 anzsrc-for:0912
5 anzsrc-for:10
6 anzsrc-for:1007
7 schema:author Nea36eb39f27846edbcf7090196f436c4
8 schema:citation sg:pub.10.1007/s00018-002-8454-2
9 sg:pub.10.1007/s00204-014-1447-8
10 sg:pub.10.1007/s10930-017-9737-7
11 sg:pub.10.1007/s11051-013-1702-6
12 sg:pub.10.1007/s11051-015-3257-1
13 sg:pub.10.1007/s11064-012-0767-4
14 sg:pub.10.1007/s11064-017-2353-2
15 sg:pub.10.1186/1471-2121-10-65
16 sg:pub.10.1186/1743-8977-11-11
17 sg:pub.10.1186/s12868-018-0429-9
18 schema:datePublished 2019-08-05
19 schema:datePublishedReg 2019-08-05
20 schema:description Silver nanoparticles (AgNPs) have been widely employed due to their antimicrobial properties; however, several studies sustain that AgNPs can induce brain damage, like the blood–brain barrier (BBB) disruption. Among the BBB defense mechanisms, the metallothioneins (MTs), a collection of proteins that regulate intracellular levels of zinc (Zn), play an important role. The goal of this work was to investigate whether the brain damage caused by an intraperitoneal administration of AgNPs (15 mg/ g body weight) at the level of the BBB permeability disruption, damage of the brain tissue, and systemic inflammation could be prevented by 24 h of previous treatment with Zn (27 mg/kg body weight). Evans blue (EB) extravasation, modification of claudin-5 expression, alterations on MTs, N-cadherin expression, and systemic inflammation were evaluated. Our results show that AgNPs induce BBB damage by increasing EB extravasation and decreasing claudin-5 expression, associated with overexpression of MTs, effects that were related with systemic inflammation, evidenced by the increase of granulocytes. Zn pretreatment partially prevented the BBB permeability from the damage induced by AgNPs, whereas the MTs expression and granulocytes count exhibited a reversal effect, suggesting that the effect of Zn could be related with the BBB regulation process. The rat brain histological analysis confirmed that pretreatment with Zn prevented at least in part the toxic effect of AgNPs. This work provides relevant information about the role of Zn as a protectant against the noxious effects of AgNPs upon the rat brain physiology.
21 schema:genre article
22 schema:isAccessibleForFree false
23 schema:isPartOf N97daafbcc7a745fbbca64a8fcafc4547
24 Nb6abb3831b4f4f608dfc5d4266340e7b
25 sg:journal.1028317
26 schema:keywords AgNPs
27 BBB damage
28 BBB permeability
29 EB extravasation
30 Evans blue extravasation
31 MTs expression
32 N-cadherin expression
33 Zn
34 Zn pretreatment
35 administration
36 alterations
37 analysis
38 antimicrobial properties
39 barrier disruption
40 blood-brain barrier disruption
41 brain
42 brain damage
43 brain histological analysis
44 brain physiology
45 brain tissue
46 claudin-5 expression
47 collection
48 collection of proteins
49 count
50 damage
51 defense mechanisms
52 disruption
53 effect
54 effect of Zn
55 exposure
56 expression
57 extravasation
58 goal
59 granulocyte count
60 granulocytes
61 h exposure
62 histological analysis
63 important role
64 increase
65 increase of granulocytes
66 inflammation
67 information
68 intracellular levels
69 intraperitoneal administration
70 levels
71 mechanism
72 metallothionein
73 modification
74 nanoparticles
75 noxious effects
76 overexpression
77 overexpression of metallothionein
78 part
79 permeability
80 permeability disruption
81 physiology
82 pretreatment
83 previous treatment
84 process
85 properties
86 protectants
87 protein
88 rat brain
89 regulation processes
90 relevant information
91 results
92 reversal effect
93 role
94 role of Zn
95 silver nanoparticles
96 study
97 systemic inflammation
98 tissue
99 toxic effects
100 treatment
101 work
102 zinc
103 schema:name Zinc protects the rat brain from damage induced by 24 h exposure to silver nanoparticles
104 schema:pagination 172
105 schema:productId N7d162d5194b845389d8a215a65b174a9
106 Nf911552ff62748a69bbce6bec1934253
107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1120144504
108 https://doi.org/10.1007/s11051-019-4616-0
109 schema:sdDatePublished 2022-08-04T17:08
110 schema:sdLicense https://scigraph.springernature.com/explorer/license/
111 schema:sdPublisher N05577d3ac9e7416b8f049fdb94153da1
112 schema:url https://doi.org/10.1007/s11051-019-4616-0
113 sgo:license sg:explorer/license/
114 sgo:sdDataset articles
115 rdf:type schema:ScholarlyArticle
116 N05577d3ac9e7416b8f049fdb94153da1 schema:name Springer Nature - SN SciGraph project
117 rdf:type schema:Organization
118 N1c982cf9968f45ff9562a12131e9c1d3 schema:affiliation grid-institutes:grid.9486.3
119 schema:familyName Rodríguez-Escamilla
120 schema:givenName Juan Carlos
121 rdf:type schema:Person
122 N229f722b190e458785d49ef314d22212 rdf:first sg:person.01115757642.88
123 rdf:rest Nd3bbc8451ebf4f3f91535c7cd3b67bcd
124 N354871fd48eb4846b7f6db8275a20fb0 schema:affiliation grid-institutes:grid.412862.b
125 schema:familyName Davalos-Rivas
126 schema:givenName Guillermo
127 rdf:type schema:Person
128 N3e9f217a52784e7286a7b6906bf8177b rdf:first sg:person.01330146671.61
129 rdf:rest rdf:nil
130 N4e6dfd828a28430491e7fa7b24680889 rdf:first sg:person.01170625340.45
131 rdf:rest Ndac661a6c5034a719499775bea3c7985
132 N523f4d671dab476daa196c8ddb6b18ee rdf:first sg:person.0626613004.93
133 rdf:rest N3e9f217a52784e7286a7b6906bf8177b
134 N75906a82431f4f06bb184c396cb5da3d rdf:first N354871fd48eb4846b7f6db8275a20fb0
135 rdf:rest N4e6dfd828a28430491e7fa7b24680889
136 N7d162d5194b845389d8a215a65b174a9 schema:name doi
137 schema:value 10.1007/s11051-019-4616-0
138 rdf:type schema:PropertyValue
139 N97daafbcc7a745fbbca64a8fcafc4547 schema:issueNumber 8
140 rdf:type schema:PublicationIssue
141 Naa3037521e6b426d8f1821f511c77888 rdf:first sg:person.07536377517.84
142 rdf:rest N523f4d671dab476daa196c8ddb6b18ee
143 Nb6abb3831b4f4f608dfc5d4266340e7b schema:volumeNumber 21
144 rdf:type schema:PublicationVolume
145 Nd3bbc8451ebf4f3f91535c7cd3b67bcd rdf:first N1c982cf9968f45ff9562a12131e9c1d3
146 rdf:rest N75906a82431f4f06bb184c396cb5da3d
147 Ndac661a6c5034a719499775bea3c7985 rdf:first sg:person.010075535033.78
148 rdf:rest Naa3037521e6b426d8f1821f511c77888
149 Nea36eb39f27846edbcf7090196f436c4 rdf:first sg:person.0714161226.05
150 rdf:rest N229f722b190e458785d49ef314d22212
151 Nf911552ff62748a69bbce6bec1934253 schema:name dimensions_id
152 schema:value pub.1120144504
153 rdf:type schema:PropertyValue
154 anzsrc-for:02 schema:inDefinedTermSet anzsrc-for:
155 schema:name Physical Sciences
156 rdf:type schema:DefinedTerm
157 anzsrc-for:0202 schema:inDefinedTermSet anzsrc-for:
158 schema:name Atomic, Molecular, Nuclear, Particle and Plasma Physics
159 rdf:type schema:DefinedTerm
160 anzsrc-for:09 schema:inDefinedTermSet anzsrc-for:
161 schema:name Engineering
162 rdf:type schema:DefinedTerm
163 anzsrc-for:0912 schema:inDefinedTermSet anzsrc-for:
164 schema:name Materials Engineering
165 rdf:type schema:DefinedTerm
166 anzsrc-for:10 schema:inDefinedTermSet anzsrc-for:
167 schema:name Technology
168 rdf:type schema:DefinedTerm
169 anzsrc-for:1007 schema:inDefinedTermSet anzsrc-for:
170 schema:name Nanotechnology
171 rdf:type schema:DefinedTerm
172 sg:journal.1028317 schema:issn 1388-0764
173 1572-896X
174 schema:name Journal of Nanoparticle Research
175 schema:publisher Springer Nature
176 rdf:type schema:Periodical
177 sg:person.010075535033.78 schema:affiliation grid-institutes:grid.412862.b
178 schema:familyName Castillo Martín del Campo
179 schema:givenName Claudia G.
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010075535033.78
181 rdf:type schema:Person
182 sg:person.01115757642.88 schema:affiliation grid-institutes:grid.9486.3
183 schema:familyName Delgado-Buenrostro
184 schema:givenName Norma Laura
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115757642.88
186 rdf:type schema:Person
187 sg:person.01170625340.45 schema:affiliation grid-institutes:grid.9486.3
188 schema:familyName Chirino
189 schema:givenName Yolanda Irasema
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170625340.45
191 rdf:type schema:Person
192 sg:person.01330146671.61 schema:affiliation grid-institutes:grid.412862.b
193 schema:familyName Gonzalez
194 schema:givenName Carmen
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330146671.61
196 rdf:type schema:Person
197 sg:person.0626613004.93 schema:affiliation grid-institutes:grid.412862.b
198 schema:familyName Vargas-Morales
199 schema:givenName Juan Manuel
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626613004.93
201 rdf:type schema:Person
202 sg:person.0714161226.05 schema:affiliation grid-institutes:grid.412862.b
203 schema:familyName Salazar-García
204 schema:givenName Samuel
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714161226.05
206 rdf:type schema:Person
207 sg:person.07536377517.84 schema:affiliation grid-institutes:grid.412862.b
208 schema:familyName Martínez-Castañón
209 schema:givenName Gabriel A.
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07536377517.84
211 rdf:type schema:Person
212 sg:pub.10.1007/s00018-002-8454-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046374327
213 https://doi.org/10.1007/s00018-002-8454-2
214 rdf:type schema:CreativeWork
215 sg:pub.10.1007/s00204-014-1447-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022485352
216 https://doi.org/10.1007/s00204-014-1447-8
217 rdf:type schema:CreativeWork
218 sg:pub.10.1007/s10930-017-9737-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091388677
219 https://doi.org/10.1007/s10930-017-9737-7
220 rdf:type schema:CreativeWork
221 sg:pub.10.1007/s11051-013-1702-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046605799
222 https://doi.org/10.1007/s11051-013-1702-6
223 rdf:type schema:CreativeWork
224 sg:pub.10.1007/s11051-015-3257-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052731922
225 https://doi.org/10.1007/s11051-015-3257-1
226 rdf:type schema:CreativeWork
227 sg:pub.10.1007/s11064-012-0767-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012938048
228 https://doi.org/10.1007/s11064-012-0767-4
229 rdf:type schema:CreativeWork
230 sg:pub.10.1007/s11064-017-2353-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090943008
231 https://doi.org/10.1007/s11064-017-2353-2
232 rdf:type schema:CreativeWork
233 sg:pub.10.1186/1471-2121-10-65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014834595
234 https://doi.org/10.1186/1471-2121-10-65
235 rdf:type schema:CreativeWork
236 sg:pub.10.1186/1743-8977-11-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047359255
237 https://doi.org/10.1186/1743-8977-11-11
238 rdf:type schema:CreativeWork
239 sg:pub.10.1186/s12868-018-0429-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103879218
240 https://doi.org/10.1186/s12868-018-0429-9
241 rdf:type schema:CreativeWork
242 grid-institutes:grid.412862.b schema:alternateName Centro de Investigacion en Ciencias de la Salud y Biomedicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico
243 Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Av. Manuel Nava No. 6., Col. Universitaria, 78210, San Luis Potosi, Mexico
244 Facultad de Estomatologia, Universidad Autónoma de San Luis Potosi, San Luis Potosi, Mexico
245 Facultad de Medicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico
246 schema:name Centro de Investigacion en Ciencias de la Salud y Biomedicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico
247 Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Av. Manuel Nava No. 6., Col. Universitaria, 78210, San Luis Potosi, Mexico
248 Facultad de Estomatologia, Universidad Autónoma de San Luis Potosi, San Luis Potosi, Mexico
249 Facultad de Medicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico
250 rdf:type schema:Organization
251 grid-institutes:grid.9486.3 schema:alternateName Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de Mexico, Avenida de los Barrios No.1, Col. Los Reyes Iztacala, Tlalnepantla de Baz. CP 54059, Estado de Mexico, Mexico
252 schema:name Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de Mexico, Avenida de los Barrios No.1, Col. Los Reyes Iztacala, Tlalnepantla de Baz. CP 54059, Estado de Mexico, Mexico
253 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...