Ontology type: schema:ScholarlyArticle
2019-08-05
AUTHORSSamuel Salazar-García, Norma Laura Delgado-Buenrostro, Juan Carlos Rodríguez-Escamilla, Guillermo Davalos-Rivas, Yolanda Irasema Chirino, Claudia G. Castillo Martín del Campo, Gabriel A. Martínez-Castañón, Juan Manuel Vargas-Morales, Carmen Gonzalez
ABSTRACTSilver nanoparticles (AgNPs) have been widely employed due to their antimicrobial properties; however, several studies sustain that AgNPs can induce brain damage, like the blood–brain barrier (BBB) disruption. Among the BBB defense mechanisms, the metallothioneins (MTs), a collection of proteins that regulate intracellular levels of zinc (Zn), play an important role. The goal of this work was to investigate whether the brain damage caused by an intraperitoneal administration of AgNPs (15 mg/ g body weight) at the level of the BBB permeability disruption, damage of the brain tissue, and systemic inflammation could be prevented by 24 h of previous treatment with Zn (27 mg/kg body weight). Evans blue (EB) extravasation, modification of claudin-5 expression, alterations on MTs, N-cadherin expression, and systemic inflammation were evaluated. Our results show that AgNPs induce BBB damage by increasing EB extravasation and decreasing claudin-5 expression, associated with overexpression of MTs, effects that were related with systemic inflammation, evidenced by the increase of granulocytes. Zn pretreatment partially prevented the BBB permeability from the damage induced by AgNPs, whereas the MTs expression and granulocytes count exhibited a reversal effect, suggesting that the effect of Zn could be related with the BBB regulation process. The rat brain histological analysis confirmed that pretreatment with Zn prevented at least in part the toxic effect of AgNPs. This work provides relevant information about the role of Zn as a protectant against the noxious effects of AgNPs upon the rat brain physiology. More... »
PAGES172
http://scigraph.springernature.com/pub.10.1007/s11051-019-4616-0
DOIhttp://dx.doi.org/10.1007/s11051-019-4616-0
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1120144504
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/02",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Physical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/09",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Engineering",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Technology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0202",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Atomic, Molecular, Nuclear, Particle and Plasma Physics",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0912",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Materials Engineering",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1007",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Nanotechnology",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Centro de Investigacion en Ciencias de la Salud y Biomedicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico",
"id": "http://www.grid.ac/institutes/grid.412862.b",
"name": [
"Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Av. Manuel Nava No. 6., Col. Universitaria, 78210, San Luis Potosi, Mexico",
"Centro de Investigacion en Ciencias de la Salud y Biomedicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico"
],
"type": "Organization"
},
"familyName": "Salazar-Garc\u00eda",
"givenName": "Samuel",
"id": "sg:person.0714161226.05",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714161226.05"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de Mexico, Avenida de los Barrios No.1, Col. Los Reyes Iztacala, Tlalnepantla de Baz. CP 54059, Estado de Mexico, Mexico",
"id": "http://www.grid.ac/institutes/grid.9486.3",
"name": [
"Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de Mexico, Avenida de los Barrios No.1, Col. Los Reyes Iztacala, Tlalnepantla de Baz. CP 54059, Estado de Mexico, Mexico"
],
"type": "Organization"
},
"familyName": "Delgado-Buenrostro",
"givenName": "Norma Laura",
"id": "sg:person.01115757642.88",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115757642.88"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de Mexico, Avenida de los Barrios No.1, Col. Los Reyes Iztacala, Tlalnepantla de Baz. CP 54059, Estado de Mexico, Mexico",
"id": "http://www.grid.ac/institutes/grid.9486.3",
"name": [
"Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de Mexico, Avenida de los Barrios No.1, Col. Los Reyes Iztacala, Tlalnepantla de Baz. CP 54059, Estado de Mexico, Mexico"
],
"type": "Organization"
},
"familyName": "Rodr\u00edguez-Escamilla",
"givenName": "Juan Carlos",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centro de Investigacion en Ciencias de la Salud y Biomedicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico",
"id": "http://www.grid.ac/institutes/grid.412862.b",
"name": [
"Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Av. Manuel Nava No. 6., Col. Universitaria, 78210, San Luis Potosi, Mexico",
"Centro de Investigacion en Ciencias de la Salud y Biomedicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico"
],
"type": "Organization"
},
"familyName": "Davalos-Rivas",
"givenName": "Guillermo",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de Mexico, Avenida de los Barrios No.1, Col. Los Reyes Iztacala, Tlalnepantla de Baz. CP 54059, Estado de Mexico, Mexico",
"id": "http://www.grid.ac/institutes/grid.9486.3",
"name": [
"Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de Mexico, Avenida de los Barrios No.1, Col. Los Reyes Iztacala, Tlalnepantla de Baz. CP 54059, Estado de Mexico, Mexico"
],
"type": "Organization"
},
"familyName": "Chirino",
"givenName": "Yolanda Irasema",
"id": "sg:person.01170625340.45",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170625340.45"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Facultad de Medicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico",
"id": "http://www.grid.ac/institutes/grid.412862.b",
"name": [
"Facultad de Medicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico"
],
"type": "Organization"
},
"familyName": "Castillo Mart\u00edn del Campo",
"givenName": "Claudia G.",
"id": "sg:person.010075535033.78",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010075535033.78"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Facultad de Estomatologia, Universidad Aut\u00f3noma de San Luis Potosi, San Luis Potosi, Mexico",
"id": "http://www.grid.ac/institutes/grid.412862.b",
"name": [
"Facultad de Estomatologia, Universidad Aut\u00f3noma de San Luis Potosi, San Luis Potosi, Mexico"
],
"type": "Organization"
},
"familyName": "Mart\u00ednez-Casta\u00f1\u00f3n",
"givenName": "Gabriel A.",
"id": "sg:person.07536377517.84",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07536377517.84"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Av. Manuel Nava No. 6., Col. Universitaria, 78210, San Luis Potosi, Mexico",
"id": "http://www.grid.ac/institutes/grid.412862.b",
"name": [
"Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Av. Manuel Nava No. 6., Col. Universitaria, 78210, San Luis Potosi, Mexico"
],
"type": "Organization"
},
"familyName": "Vargas-Morales",
"givenName": "Juan Manuel",
"id": "sg:person.0626613004.93",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626613004.93"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centro de Investigacion en Ciencias de la Salud y Biomedicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico",
"id": "http://www.grid.ac/institutes/grid.412862.b",
"name": [
"Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Av. Manuel Nava No. 6., Col. Universitaria, 78210, San Luis Potosi, Mexico",
"Centro de Investigacion en Ciencias de la Salud y Biomedicina, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico"
],
"type": "Organization"
},
"familyName": "Gonzalez",
"givenName": "Carmen",
"id": "sg:person.01330146671.61",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330146671.61"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1186/1471-2121-10-65",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014834595",
"https://doi.org/10.1186/1471-2121-10-65"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00204-014-1447-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022485352",
"https://doi.org/10.1007/s00204-014-1447-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11051-013-1702-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046605799",
"https://doi.org/10.1007/s11051-013-1702-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11064-012-0767-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012938048",
"https://doi.org/10.1007/s11064-012-0767-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11064-017-2353-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1090943008",
"https://doi.org/10.1007/s11064-017-2353-2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10930-017-9737-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1091388677",
"https://doi.org/10.1007/s10930-017-9737-7"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12868-018-0429-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103879218",
"https://doi.org/10.1186/s12868-018-0429-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00018-002-8454-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046374327",
"https://doi.org/10.1007/s00018-002-8454-2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1743-8977-11-11",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047359255",
"https://doi.org/10.1186/1743-8977-11-11"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11051-015-3257-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052731922",
"https://doi.org/10.1007/s11051-015-3257-1"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-08-05",
"datePublishedReg": "2019-08-05",
"description": "Silver nanoparticles (AgNPs) have been widely employed due to their antimicrobial properties; however, several studies sustain that AgNPs can induce brain damage, like the blood\u2013brain barrier (BBB) disruption. Among the BBB defense mechanisms, the metallothioneins (MTs), a collection of proteins that regulate intracellular levels of zinc (Zn), play an important role. The goal of this work was to investigate whether the brain damage caused by an intraperitoneal administration of AgNPs (15\u00a0mg/ g body weight) at the level of the BBB permeability disruption, damage of the brain tissue, and systemic inflammation could be prevented by 24\u00a0h of previous treatment with Zn (27\u00a0mg/kg body weight). Evans blue (EB) extravasation, modification of claudin-5 expression, alterations on MTs, N-cadherin expression, and systemic inflammation were evaluated. Our results show that AgNPs induce BBB damage by increasing EB extravasation and decreasing claudin-5 expression, associated with overexpression of MTs, effects that were related with systemic inflammation, evidenced by the increase of granulocytes. Zn pretreatment partially prevented the BBB permeability from the damage induced by AgNPs, whereas the MTs expression and granulocytes count exhibited a reversal effect, suggesting that the effect of Zn could be related with the BBB regulation process. The rat brain histological analysis confirmed that pretreatment with Zn prevented at least in part the toxic effect of AgNPs. This work provides relevant information about the role of Zn as a protectant against the noxious effects of AgNPs upon the rat brain physiology.",
"genre": "article",
"id": "sg:pub.10.1007/s11051-019-4616-0",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1028317",
"issn": [
"1388-0764",
"1572-896X"
],
"name": "Journal of Nanoparticle Research",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "8",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "21"
}
],
"keywords": [
"systemic inflammation",
"claudin-5 expression",
"brain damage",
"blood-brain barrier disruption",
"brain histological analysis",
"Evans blue extravasation",
"increase of granulocytes",
"overexpression of metallothionein",
"MTs expression",
"BBB damage",
"EB extravasation",
"BBB permeability",
"barrier disruption",
"granulocyte count",
"intraperitoneal administration",
"Zn pretreatment",
"rat brain",
"N-cadherin expression",
"permeability disruption",
"brain tissue",
"brain physiology",
"inflammation",
"histological analysis",
"previous treatment",
"noxious effects",
"intracellular levels",
"extravasation",
"toxic effects",
"h exposure",
"reversal effect",
"defense mechanisms",
"expression",
"damage",
"role of Zn",
"metallothionein",
"pretreatment",
"administration",
"granulocytes",
"brain",
"disruption",
"important role",
"effect",
"levels",
"treatment",
"tissue",
"alterations",
"role",
"exposure",
"overexpression",
"count",
"physiology",
"relevant information",
"antimicrobial properties",
"protein",
"study",
"increase",
"zinc",
"protectants",
"effect of Zn",
"mechanism",
"regulation processes",
"permeability",
"analysis",
"results",
"goal",
"modification",
"collection",
"part",
"information",
"collection of proteins",
"work",
"process",
"AgNPs",
"Zn",
"properties",
"silver nanoparticles",
"nanoparticles"
],
"name": "Zinc protects the rat brain from damage induced by 24 h exposure to silver nanoparticles",
"pagination": "172",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1120144504"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s11051-019-4616-0"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s11051-019-4616-0",
"https://app.dimensions.ai/details/publication/pub.1120144504"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T17:08",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_821.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s11051-019-4616-0"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11051-019-4616-0'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11051-019-4616-0'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11051-019-4616-0'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11051-019-4616-0'
This table displays all metadata directly associated to this object as RDF triples.
253 TRIPLES
21 PREDICATES
115 URIs
93 LITERALS
6 BLANK NODES