Evaluation of morphology, aggregation pattern and size-dependent drug-loading efficiency of gold nanoparticles stabilised with poly (2-vinyl pyridine) View Full Text


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Article Info

DATE

2017-07-20

AUTHORS

Sana Rahim, Syed Abid Ali, Farid Ahmed, Muhammad Imran, Muhammad Raza Shah, Muhammad Imran Malik

ABSTRACT

Presence of basic nitrogen throughout the chain of poly(2-vinylpyridine) make them alluring candidate for applications requiring chelation of heavy metals. In this study, we report the use of poly (2-vinylpyridine) (P2VP) homopolymers of varying molar masses for the stabilization of gold nanoparticles for the first time. A study based on AFM, DLS and UV-visible spectroscopy was conducted to establish a correlation of the molar mass of P2VP with the size and distribution of the gold nanoparticles. Systematic and gradual change in the absorbance intensity and shift in SPR band of gold nanoparticles were also observed upon variations in treatment temperature, concentration of polymer, residence time, pH, and electrolyte concentration. The results obtained by UV-visible spectroscopy, AFM and DLS are complementary. The size of the P2VP-stabilised AuNPs was found to be in the range of 20–130 nms. At last, the effect of the size of P2VP-stabilised AuNPs (directly related to the molar mass of P2VP) on the drug-loading efficiency is evaluated.Graphical Abstractᅟ More... »

PAGES

259

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11051-017-3933-4

DOI

http://dx.doi.org/10.1007/s11051-017-3933-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090832585


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