Pulmonary toxicity of well-dispersed cerium oxide nanoparticles following intratracheal instillation and inhalation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-11-13

AUTHORS

Yasuo Morimoto, Hiroto Izumi, Yukiko Yoshiura, Taisuke Tomonaga, Takako Oyabu, Toshihiko Myojo, Kazuaki Kawai, Kazuhiro Yatera, Manabu Shimada, Masaru Kubo, Kazuhiro Yamamoto, Shinichi Kitajima, Etsushi Kuroda, Kenji Kawaguchi, Takeshi Sasaki

ABSTRACT

We performed inhalation and intratracheal instillation studies of cerium dioxide (CeO2) nanoparticles in order to investigate their pulmonary toxicity, and observed pulmonary inflammation not only in the acute and but also in the chronic phases. In the intratracheal instillation study, F344 rats were exposed to 0.2 mg or 1 mg of CeO2 nanoparticles. Cell analysis and chemokines in bronchoalveolar lavage fluid (BALF) were analyzed from 3 days to 6 months following the instillation. In the inhalation study, rats were exposed to the maximum concentration of inhaled CeO2 nanoparticles (2, 10 mg/m3, respectively) for 4 weeks (6 h/day, 5 days/week). The same endpoints as in the intratracheal instillation study were examined from 3 days to 3 months after the end of the exposure. The intratracheal instillation of CeO2 nanoparticles caused a persistent increase in the total and neutrophil number in BALF and in the concentration of cytokine-induced neutrophil chemoattractant (CINC)-1, CINC-2, chemokine for neutrophil, and heme oxygenase-1 (HO-1), an oxidative stress marker, in BALF during the observation time. The inhalation of CeO2 nanoparticles also induced a persistent influx of neutrophils and expression of CINC-1, CINC-2, and HO-1 in BALF. Pathological features revealed that inflammatory cells, including macrophages and neutrophils, invaded the alveolar space in both studies. Taken together, the CeO2 nanoparticles induced not only acute but also chronic inflammation in the lung, suggesting that CeO2 nanoparticles have a pulmonary toxicity that can lead to irreversible lesions. More... »

PAGES

442

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11051-015-3249-1

DOI

http://dx.doi.org/10.1007/s11051-015-3249-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024252516

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26594128


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15 schema:description We performed inhalation and intratracheal instillation studies of cerium dioxide (CeO2) nanoparticles in order to investigate their pulmonary toxicity, and observed pulmonary inflammation not only in the acute and but also in the chronic phases. In the intratracheal instillation study, F344 rats were exposed to 0.2 mg or 1 mg of CeO2 nanoparticles. Cell analysis and chemokines in bronchoalveolar lavage fluid (BALF) were analyzed from 3 days to 6 months following the instillation. In the inhalation study, rats were exposed to the maximum concentration of inhaled CeO2 nanoparticles (2, 10 mg/m3, respectively) for 4 weeks (6 h/day, 5 days/week). The same endpoints as in the intratracheal instillation study were examined from 3 days to 3 months after the end of the exposure. The intratracheal instillation of CeO2 nanoparticles caused a persistent increase in the total and neutrophil number in BALF and in the concentration of cytokine-induced neutrophil chemoattractant (CINC)-1, CINC-2, chemokine for neutrophil, and heme oxygenase-1 (HO-1), an oxidative stress marker, in BALF during the observation time. The inhalation of CeO2 nanoparticles also induced a persistent influx of neutrophils and expression of CINC-1, CINC-2, and HO-1 in BALF. Pathological features revealed that inflammatory cells, including macrophages and neutrophils, invaded the alveolar space in both studies. Taken together, the CeO2 nanoparticles induced not only acute but also chronic inflammation in the lung, suggesting that CeO2 nanoparticles have a pulmonary toxicity that can lead to irreversible lesions.
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21 schema:keywords Acute
22 CINC-1
23 CINC-2
24 CeO2 nanoparticles
25 F344 rats
26 HO-1
27 alveolar space
28 analysis
29 bronchoalveolar lavage fluid
30 cell analysis
31 cells
32 cerium dioxide nanoparticles
33 cerium oxide nanoparticles
34 chemoattractant
35 chemokines
36 chronic inflammation
37 chronic phase
38 concentration
39 cytokine-induced neutrophil chemoattractant
40 days
41 dioxide nanoparticles
42 end
43 endpoint
44 exposure
45 expression
46 features
47 fluid
48 increase
49 inflammation
50 inflammatory cells
51 influx
52 inhalation
53 inhalation studies
54 instillation
55 instillation studies
56 intratracheal instillation
57 intratracheal instillation study
58 irreversible lesions
59 lavage fluid
60 lesions
61 lung
62 macrophages
63 markers
64 maximum concentration
65 months
66 nanoparticles
67 neutrophil chemoattractant
68 neutrophil numbers
69 neutrophils
70 number
71 observation time
72 order
73 oxidative stress markers
74 oxide nanoparticles
75 oxygenase-1
76 pathological features
77 persistent increase
78 persistent influx
79 phase
80 pulmonary inflammation
81 pulmonary toxicity
82 rats
83 same endpoints
84 space
85 stress markers
86 study
87 time
88 total
89 toxicity
90 weeks
91 schema:name Pulmonary toxicity of well-dispersed cerium oxide nanoparticles following intratracheal instillation and inhalation
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