Pulmonary toxicity of well-dispersed titanium dioxide nanoparticles following intratracheal instillation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-06-02

AUTHORS

Yukiko Yoshiura, Hiroto Izumi, Takako Oyabu, Masayoshi Hashiba, Tatsunori Kambara, Yohei Mizuguchi, Byeong Woo Lee, Takami Okada, Taisuke Tomonaga, Toshihiko Myojo, Kazuhiro Yamamoto, Shinichi Kitajima, Masanori Horie, Etsushi Kuroda, Yasuo Morimoto

ABSTRACT

In order to investigate the pulmonary toxicity of titanium dioxide (TiO2) nanoparticles, we performed an intratracheal instillation study with rats of well-dispersed TiO2 nanoparticles and examined the pulmonary inflammation and histopathological changes in the lung. Wistar Hannover rats were intratracheally administered 0.2 mg (0.66 mg/kg) and 1.0 mg (3.3 mg/kg) of well-dispersed TiO2 nanoparticles (P90; diameter of agglomerates: 25 nm), then the pulmonary inflammation responses were examined from 3 days to 6 months after the instillation, and the pathological features were examined up to 24 months. Transient inflammation and the upregulation of chemokines in the broncho-alveolar lavage fluid were observed for 1 month. No respiratory tumors or severe fibrosis were observed during the recovery time. These data suggest that transient inflammation induced by TiO2 may not lead to chronic, irreversible legions in the lung, and that TiO2 nanoparticles may not have a high potential for lung disorder. More... »

PAGES

241

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11051-015-3054-x

DOI

http://dx.doi.org/10.1007/s11051-015-3054-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027369457

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26069452


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33 high potential
34 histopathological changes
35 inflammation
36 inflammation response
37 instillation
38 instillation studies
39 intratracheal instillation
40 intratracheal instillation study
41 lavage fluid
42 legion
43 lung
44 lung disorders
45 months
46 nanoparticles
47 order
48 pathological features
49 potential
50 pulmonary inflammation
51 pulmonary inflammation response
52 pulmonary toxicity
53 rats
54 recovery time
55 respiratory tumors
56 response
57 severe fibrosis
58 study
59 time
60 titanium dioxide nanoparticles
61 toxicity
62 transient inflammation
63 tumors
64 upregulation
65 upregulation of chemokines
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