Stem cell therapy in Alzheimer’s disease: possible benefits and limiting drawbacks View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02

AUTHORS

Masoume Alipour, Seyed Massood Nabavi, Leila Arab, Massoud Vosough, Hossein Pakdaman, Ehsan Ehsani, Koorosh Shahpasand

ABSTRACT

Alzheimer's disease (AD) is the sixth leading cause of death globally and the main reason for dementia in elderly people. AD is a long-term and progressive neurodegenerative disorder that steadily worsens memory and communicating skills eventually leads to a disabled person of performing simple daily tasks. Unfortunately, numerous clinical trials exploring new therapeutic drugs have encountered disappointing outcomes in terms of improved cognitive performance since they are not capable of halting or stimulating the regeneration of already-damaged neural cells, and merely provide symptomatic relief. Therefore, a deeper understanding of the mechanism of action of stem cell may contribute to the development of novel and effective therapies. The revolutionary discovery of stem cells has cast a new hope for the development of disease-modifying treatments for AD, in terms of their potency in the replenishment of lost cells via differentiating towards specific lineages, stimulating in situ neurogenesis, and delivering the therapeutic agents to the brain. Herein, firstly, we explore the pathophysiology of AD. Next, we summarize the most recent preclinical stem cell reports designed for AD treatment, their benefits and outcomes according to cell type. We briefly review relevant clinical trials and their potential clinical applications in order to find a unique solution to effectively relieve the patients' pain. More... »

PAGES

1425-1446

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11033-018-4499-7

    DOI

    http://dx.doi.org/10.1007/s11033-018-4499-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1110754525

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30565076


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