The genetic background of antibiotic resistance among clinical uropathogenic Escherichia coli strains View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-10

AUTHORS

Wioletta Adamus-Białek, Anna Baraniak, Monika Wawszczak, Stanisław Głuszek, Beata Gad, Klaudia Wróbel, Paulina Bator, Marta Majchrzak, Paweł Parniewski

ABSTRACT

The spreading mechanisms of antibiotic resistance are related to many bacterial and environment factors. The overuse of antibiotics is leading to an unceasing emergence of new multidrug resistant strains. This problem also concerns uropathogenic Escherichia coli strains, which is the most common pathogen causing urinary tract infections. The aim of this study was the genetic analysis of antibiotic resistance in comparison to the phenotypic background of E. coli strains. The characterized collection of E. coli strains isolated 10 years ago from the urine samples of patients with urinary tract infections was used for antimicrobial susceptibility testing (the disc diffusion method) and analysis of antibiotic resistance genes (PCR reaction, sequencing). Additionally, the presence of ESBL strains was analyzed. Fourteen genes were associated with resistance to beta-lactams, aminoglycosides, sulfonamides and quinolones. The genetic analysis revealed that blaTEM-1 and sul2 were present in almost all of the studied strains. Other drug-resistance genes were very rare or non-existent. Otherwise, the phenotypic resistance to fluoroquinolones was well correlated with the genotypic background of the studied bacteria. The presence of particular genes and specific mutations indicate a high bacterial potential to multidrug resistance. On the other hand, it needs to be emphasized that the standard disk diffusion test for the routine antimicrobial susceptibility analysis is still the best way to estimate the current situation of bacterial drug-resistance. More... »

PAGES

1055-1065

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11033-018-4254-0

    DOI

    http://dx.doi.org/10.1007/s11033-018-4254-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1105598314

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30008141


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