Association of the colorectal cancer and MDR1 gene polymorphism in an Iranian population View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-02-02

AUTHORS

Azam Khedri, Amireh Nejat-Shokouhi, Roham Salek, Habibollah Esmaeili, Ali Mokhtarifar, Reza Entezari Heravi, Farnoosh Tatari, Javad Behravan, Behnoosh Miladpour, Shahireh Omidvar Tehrani

ABSTRACT

The human multidrug resistance (MDR1) gene product P-glycoprotein is highly expressed in intestinal epithelial cells, where it constitutes a barrier against xenobiotics, bacterial toxins, drugs and other biologically active compounds, possibly carcinogens. In this study, an association of MDR1 gene polymorphism and the occurrence of colorectal cancer were evaluated. In this case-control-designed 118 unrelated colorectal cancer and 137 sex-and-ages matched healthy controls were enrolled. The C3435T MDR1 gene polymorphism was identified using the polymerase chain reaction-restriction fragment length polymorphism method. Significantly increased frequencies of the 3435T allele and the 3435TT were observed in patients with colorectal cancer compared with controls (P = 0.03; OR, 95% CI; 1.46 for 3435T allele and P = 0.003; OR, 95% CI; 2.2 for 3435TT genotype). In contrast, frequency of genotype TT was significantly higher in controls compared to colorectal cancer (P = 0.006; OR, 95% CI; 0.49 for TC genotype). In this study suggest that C3435T MDR1 polymorphism has an association with colorectal cancer. The results support that the presence of allele C results in decreased susceptibility to colorectal cancer. More... »

PAGES

2939-2943

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11033-010-9957-9

DOI

http://dx.doi.org/10.1007/s11033-010-9957-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025150147

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20127181


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