Ontology type: schema:ScholarlyArticle
2010-12
AUTHORSDan Du, Yong-Hui Shi, Guo-Wei Le
ABSTRACTHigh glycemic index diet can induce multiple diseases. Many research indicated that oxidative stress played important role in many pathological conditions. However, the impact of gene expression and dietary habit on oxidation process are still less clear. We used high-glucose diet to feed C57BL/6J mice for 4 weeks, measured the redox status, physiological and biochemical changes related to diabetes and consequence of metabolic syndrome (nonalcoholic fatty liver, cardiovascular disease), and detected the expressions of 14,446 genes in liver of C57BL/6J mice with DNA microarray. The results showed high-glucose diet induced elevated fatty acid accumulation in liver, insulin resistance index and higher weight in C57BL/6J mice, which indicated high-glucose diet caused to the initiation and development of diabetes and consequence of metabolic syndrome. The results also showed high-glucose diet induced oxidative stress in liver of C57BL/6J mice, which might the cause of initiation and development of diabetes and consequence of metabolic syndrome. Microarray analysis found expressions of genes related to thiol redox, fatty acid oxidation in peroxisome and cytochrome P450 were significantly changed, indicating system in which non-enzyme antioxidant capacity was impaired and sources from which reactive oxygen species (ROS) generated, which revealed the molecular mechanism of oxidative stress induced by high-glucose diet. We validated our microarray findings by conducting real-time RT-PCR assays on selected genes. More... »
PAGES3833-3839
http://scigraph.springernature.com/pub.10.1007/s11033-010-0039-9
DOIhttp://dx.doi.org/10.1007/s11033-010-0039-9
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1020777817
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/20217240
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Diabetes Mellitus",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Diet",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Free Radical Scavengers",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Expression Profiling",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Expression Regulation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Glucose",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Liver",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Metabolic Syndrome",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, Inbred C57BL",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Oligonucleotide Array Sequence Analysis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Oxidation-Reduction",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Oxidative Stress",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "RNA, Messenger",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Reactive Oxygen Species",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Reproducibility of Results",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Reverse Transcriptase Polymerase Chain Reaction",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Jiangnan University",
"id": "https://www.grid.ac/institutes/grid.258151.a",
"name": [
"State Key Lab of Food Science and Technology, Jiangnan University, 1800 Lihu Road, 214122, Wuxi, Jiangsu Province, China"
],
"type": "Organization"
},
"familyName": "Du",
"givenName": "Dan",
"id": "sg:person.0641345023.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641345023.07"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Jiangnan University",
"id": "https://www.grid.ac/institutes/grid.258151.a",
"name": [
"State Key Lab of Food Science and Technology, Jiangnan University, 1800 Lihu Road, 214122, Wuxi, Jiangsu Province, China"
],
"type": "Organization"
},
"familyName": "Shi",
"givenName": "Yong-Hui",
"id": "sg:person.0674200354.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674200354.07"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Jiangnan University",
"id": "https://www.grid.ac/institutes/grid.258151.a",
"name": [
"State Key Lab of Food Science and Technology, Jiangnan University, 1800 Lihu Road, 214122, Wuxi, Jiangsu Province, China"
],
"type": "Organization"
},
"familyName": "Le",
"givenName": "Guo-Wei",
"id": "sg:person.016101750457.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016101750457.19"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1182/blood-2006-02-003681",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002773938"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0003-2697(79)90738-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004403568"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m509255200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009282141"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11033-009-9622-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010739641",
"https://doi.org/10.1007/s11033-009-9622-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11033-009-9622-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010739641",
"https://doi.org/10.1007/s11033-009-9622-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11033-009-9622-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010739641",
"https://doi.org/10.1007/s11033-009-9622-3"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/diabetes.54.6.1615",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011072556"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6604496",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011782627",
"https://doi.org/10.1038/sj.bjc.6604496"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.febslet.2007.06.044",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015071106"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1113/expphysiol.1997.sp004024",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016423401"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0167-4838(85)90098-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018301333"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0167-4838(85)90098-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018301333"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci8814",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019335834"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/mco.0b013e328302f3ec",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020108562"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/mco.0b013e328302f3ec",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020108562"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/jama.299.19.2287",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021524189"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mcb.22.23.8226-8240.2002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023712551"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1146/annurev.nutr.21.1.193",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024731659"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-3-0348-6784-9_5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027420601",
"https://doi.org/10.1007/978-3-0348-6784-9_5"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0165-1110(88)90022-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034158086"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0165-1110(88)90022-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034158086"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj20020533",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038576339"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj20020533",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038576339"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/ajpendo.00299.2007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043741775"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/diabetes.53.3.701",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043973930"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11033-009-9877-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046023914",
"https://doi.org/10.1007/s11033-009-9877-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11033-009-9877-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046023914",
"https://doi.org/10.1007/s11033-009-9877-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11033-009-9877-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046023914",
"https://doi.org/10.1007/s11033-009-9877-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1385/cbb:32:1-3:73",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047678436",
"https://doi.org/10.1385/cbb:32:1-3:73"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1167/iovs.06-0275",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047817536"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0006-2952(89)90338-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052008156"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0006-2952(89)90338-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052008156"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jcem.85.8.6854",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064323691"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/diacare.19.10.1138",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1070746938"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1076750128",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077513310",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/ajcn/87.3.627",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1077617179"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1096/fasebj.10.11.8836037",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1082970951"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/physrev.1997.77.2.517",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083076181"
],
"type": "CreativeWork"
}
],
"datePublished": "2010-12",
"datePublishedReg": "2010-12-01",
"description": "High glycemic index diet can induce multiple diseases. Many research indicated that oxidative stress played important role in many pathological conditions. However, the impact of gene expression and dietary habit on oxidation process are still less clear. We used high-glucose diet to feed C57BL/6J mice for 4 weeks, measured the redox status, physiological and biochemical changes related to diabetes and consequence of metabolic syndrome (nonalcoholic fatty liver, cardiovascular disease), and detected the expressions of 14,446 genes in liver of C57BL/6J mice with DNA microarray. The results showed high-glucose diet induced elevated fatty acid accumulation in liver, insulin resistance index and higher weight in C57BL/6J mice, which indicated high-glucose diet caused to the initiation and development of diabetes and consequence of metabolic syndrome. The results also showed high-glucose diet induced oxidative stress in liver of C57BL/6J mice, which might the cause of initiation and development of diabetes and consequence of metabolic syndrome. Microarray analysis found expressions of genes related to thiol redox, fatty acid oxidation in peroxisome and cytochrome P450 were significantly changed, indicating system in which non-enzyme antioxidant capacity was impaired and sources from which reactive oxygen species (ROS) generated, which revealed the molecular mechanism of oxidative stress induced by high-glucose diet. We validated our microarray findings by conducting real-time RT-PCR assays on selected genes.",
"genre": "research_article",
"id": "sg:pub.10.1007/s11033-010-0039-9",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.4937125",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1018503",
"issn": [
"0301-4851",
"1573-4978"
],
"name": "Molecular Biology Reports",
"type": "Periodical"
},
{
"issueNumber": "8",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "37"
}
],
"name": "Oxidative stress induced by high-glucose diet in liver of C57BL/6J mice and its underlying mechanism",
"pagination": "3833-3839",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"63004fd851bb68ff525d612bfe837e0aed2deb6d37f9b4b63b865f37694642e6"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"20217240"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"0403234"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s11033-010-0039-9"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1020777817"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s11033-010-0039-9",
"https://app.dimensions.ai/details/publication/pub.1020777817"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T09:49",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89785_00000001.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007%2Fs11033-010-0039-9"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11033-010-0039-9'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11033-010-0039-9'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11033-010-0039-9'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11033-010-0039-9'
This table displays all metadata directly associated to this object as RDF triples.
250 TRIPLES
21 PREDICATES
77 URIs
39 LITERALS
27 BLANK NODES