Computational identification and characteristics of novel microRNAs from the silkworm (Bombyx mori L.) View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-10

AUTHORS

Yong Huang, Quan Zou, Shun Ming Tang, Li Gang Wang, Xing Jia Shen

ABSTRACT

MicroRNAs (miRNAs) are a class of non-protein coding small RNAs that regulate expression of genes at post-transcriptional levels. Increasing evidence has shown that miRNAs play multiple roles in biological processes, including development, cell proliferation and apoptosis. Based on the conservation of miRNAs sequence, using a computational homology search based on genomic survey sequence analysis, a total of 16 novel miRNAs were identified and characteristics such as family and evolutionary conservation have been described. By using these newly identified miRNAs, the mRNA database of silkworm was blasted and 21 potential targets of miRNAs were detected. Most of these miRNA targeted genes were predicted to encode transcription factors. The semi-stem loop RT-PCR based assays were performed and found that silkworm miRNAs have diverse expression patterns during development. More... »

PAGES

3171-3176

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11033-009-9897-4

DOI

http://dx.doi.org/10.1007/s11033-009-9897-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017419281

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19823945


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