Ontology type: schema:ScholarlyArticle Open Access: True
2013-10-23
AUTHORSYuni Wahyuni, Vanessa Stahl-Hermes, Ana-Rosa Ballester, Ric C. H. de Vos, Roeland E. Voorrips, Awang Maharijaya, Jos Molthoff, Marcela Viquez Zamora, Enny Sudarmonowati, Ana Carolina Maisonnave Arisi, Raoul J. Bino, Arnaud G. Bovy
ABSTRACTUntargeted LCMS profiling of semi-polar metabolites followed by metabolite quantitative trait locus (mQTL) analysis was performed in ripe pepper fruits of 113 F2 plants derived from a cross between Capsicum annuum AC1979 (no. 19) and Capsicum chinense No. 4661 Selection (no. 18). The parental accessions were selected based on their variation in fruit morphological characteristics and fruit content of some target phytonutrients. Clear segregation of fruit colour and fruit metabolite profiles was observed in the F2 population. The F2 plants formed three clusters based on their metabolite profiles. Of the total of 542 metabolites, 52 could be annotated, including a range of flavonoids, such as flavone C-glycosides, flavonol O-glycosides and naringenin chalcone, as well as several phenylpropanoids, a capsaicin analogue, fatty acid derivatives and amino acid derivatives. Interval mapping revealed 279 mQTLs in total. Two mQTL hotspots were found on chromosome 9. These two chromosomal regions regulated the relative levels of 35 and 103 metabolites, respectively. Analysis also revealed an mQTL for a capsaicin analogue, located on chromosome 7. Confirmation of flavonoid mQTLs using a set of six flavonoid candidate gene markers and their corresponding expression data (expression QTLs) indicated the Ca-MYB12 transcription factor gene on chromosome 1 and the gene encoding flavone synthase (FS-2) on chromosome 6 as likely causative genes determining the variation in naringenin chalcone and flavone C-glycosides, respectively, in this population. The combination of large-scale metabolite profiling and QTL analysis provided valuable insight into the genomic regions and genes important for the production of (secondary) metabolites in pepper fruit. This will impact breeding strategies aimed at optimising the content of specific metabolites in pepper fruit. More... »
PAGES503-518
http://scigraph.springernature.com/pub.10.1007/s11032-013-9967-0
DOIhttp://dx.doi.org/10.1007/s11032-013-9967-0
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1010605700
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/24532977
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Genetics",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Research Centre for Biotechnology, Indonesian Institute of Sciences, Jl. Raya Bogor KM. 46, Cibinong, 16910, Bogor, Indonesia",
"id": "http://www.grid.ac/institutes/grid.249566.a",
"name": [
"Wageningen UR Plant Breeding, 6708 PB, Wageningen, The Netherlands",
"Research Centre for Biotechnology, Indonesian Institute of Sciences, Jl. Raya Bogor KM. 46, Cibinong, 16910, Bogor, Indonesia"
],
"type": "Organization"
},
"familyName": "Wahyuni",
"givenName": "Yuni",
"id": "sg:person.01365010574.75",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365010574.75"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Departamento de Ci\u00eancia e Tecnologia de Alimentos, Centro de Ci\u00eancias Agr\u00e1rias, Universidade Federal de Santa Catarina, Rod. Admar Gonzaga, 1346, 88034-001, Florian\u00f3polis, SC, Brazil",
"id": "http://www.grid.ac/institutes/grid.411237.2",
"name": [
"Wageningen UR Plant Breeding, 6708 PB, Wageningen, The Netherlands",
"Departamento de Ci\u00eancia e Tecnologia de Alimentos, Centro de Ci\u00eancias Agr\u00e1rias, Universidade Federal de Santa Catarina, Rod. Admar Gonzaga, 1346, 88034-001, Florian\u00f3polis, SC, Brazil"
],
"type": "Organization"
},
"familyName": "Stahl-Hermes",
"givenName": "Vanessa",
"id": "sg:person.014255632351.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014255632351.53"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Instituto de Agroqu\u00edmica y Tecnolog\u00eda de Alimentos, Consejo Superior de Investigaciones Cient\u00edficas (IATA-CSIC), Avenida Agust\u00edn Escardino 7, 46980, Paterna, Valencia, Spain",
"id": "http://www.grid.ac/institutes/grid.419051.8",
"name": [
"Wageningen UR Plant Breeding, 6708 PB, Wageningen, The Netherlands",
"Instituto de Agroqu\u00edmica y Tecnolog\u00eda de Alimentos, Consejo Superior de Investigaciones Cient\u00edficas (IATA-CSIC), Avenida Agust\u00edn Escardino 7, 46980, Paterna, Valencia, Spain"
],
"type": "Organization"
},
"familyName": "Ballester",
"givenName": "Ana-Rosa",
"id": "sg:person.01173407212.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173407212.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Netherlands Metabolomics Centre, Einsteinweg 55, 2333 CC, Leiden, The Netherlands",
"id": "http://www.grid.ac/institutes/grid.450196.f",
"name": [
"Plant Research International, 6700 AA, Wageningen, The Netherlands",
"Netherlands Metabolomics Centre, Einsteinweg 55, 2333 CC, Leiden, The Netherlands"
],
"type": "Organization"
},
"familyName": "de Vos",
"givenName": "Ric C. H.",
"id": "sg:person.014575024362.22",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014575024362.22"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wageningen UR Plant Breeding, 6708 PB, Wageningen, The Netherlands",
"id": "http://www.grid.ac/institutes/grid.4818.5",
"name": [
"Wageningen UR Plant Breeding, 6708 PB, Wageningen, The Netherlands"
],
"type": "Organization"
},
"familyName": "Voorrips",
"givenName": "Roeland E.",
"id": "sg:person.01331443365.83",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331443365.83"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Bogor Agricultural University, Jl. Raya Darmaga, 16680, Bogor, Indonesia",
"id": "http://www.grid.ac/institutes/grid.440754.6",
"name": [
"Wageningen UR Plant Breeding, 6708 PB, Wageningen, The Netherlands",
"Bogor Agricultural University, Jl. Raya Darmaga, 16680, Bogor, Indonesia"
],
"type": "Organization"
},
"familyName": "Maharijaya",
"givenName": "Awang",
"id": "sg:person.014763671356.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014763671356.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wageningen UR Plant Breeding, 6708 PB, Wageningen, The Netherlands",
"id": "http://www.grid.ac/institutes/grid.4818.5",
"name": [
"Wageningen UR Plant Breeding, 6708 PB, Wageningen, The Netherlands"
],
"type": "Organization"
},
"familyName": "Molthoff",
"givenName": "Jos",
"id": "sg:person.01323606635.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323606635.37"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wageningen UR Plant Breeding, 6708 PB, Wageningen, The Netherlands",
"id": "http://www.grid.ac/institutes/grid.4818.5",
"name": [
"Wageningen UR Plant Breeding, 6708 PB, Wageningen, The Netherlands"
],
"type": "Organization"
},
"familyName": "Zamora",
"givenName": "Marcela Viquez",
"id": "sg:person.011336043551.61",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011336043551.61"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Research Centre for Biotechnology, Indonesian Institute of Sciences, Jl. Raya Bogor KM. 46, Cibinong, 16910, Bogor, Indonesia",
"id": "http://www.grid.ac/institutes/grid.249566.a",
"name": [
"Research Centre for Biotechnology, Indonesian Institute of Sciences, Jl. Raya Bogor KM. 46, Cibinong, 16910, Bogor, Indonesia"
],
"type": "Organization"
},
"familyName": "Sudarmonowati",
"givenName": "Enny",
"id": "sg:person.01234113513.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234113513.37"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Departamento de Ci\u00eancia e Tecnologia de Alimentos, Centro de Ci\u00eancias Agr\u00e1rias, Universidade Federal de Santa Catarina, Rod. Admar Gonzaga, 1346, 88034-001, Florian\u00f3polis, SC, Brazil",
"id": "http://www.grid.ac/institutes/grid.411237.2",
"name": [
"Departamento de Ci\u00eancia e Tecnologia de Alimentos, Centro de Ci\u00eancias Agr\u00e1rias, Universidade Federal de Santa Catarina, Rod. Admar Gonzaga, 1346, 88034-001, Florian\u00f3polis, SC, Brazil"
],
"type": "Organization"
},
"familyName": "Arisi",
"givenName": "Ana Carolina Maisonnave",
"id": "sg:person.0613112665.16",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613112665.16"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Laboratory of Plant Physiology, Wageningen University, 6700 AR, Wageningen, The Netherlands",
"id": "http://www.grid.ac/institutes/grid.4818.5",
"name": [
"Laboratory of Plant Physiology, Wageningen University, 6700 AR, Wageningen, The Netherlands"
],
"type": "Organization"
},
"familyName": "Bino",
"givenName": "Raoul J.",
"id": "sg:person.0667062740.44",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667062740.44"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Plant Research International, 6700 AA, Wageningen, The Netherlands",
"id": "http://www.grid.ac/institutes/grid.4818.5",
"name": [
"Wageningen UR Plant Breeding, 6708 PB, Wageningen, The Netherlands",
"Plant Research International, 6700 AA, Wageningen, The Netherlands"
],
"type": "Organization"
},
"familyName": "Bovy",
"givenName": "Arnaud G.",
"id": "sg:person.01117537740.62",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117537740.62"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s11306-012-0432-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037075460",
"https://doi.org/10.1007/s11306-012-0432-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/88150",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035031775",
"https://doi.org/10.1038/88150"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1005966313415",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025846991",
"https://doi.org/10.1023/a:1005966313415"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00122-003-1405-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006153497",
"https://doi.org/10.1007/s00122-003-1405-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00122-006-0415-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026501664",
"https://doi.org/10.1007/s00122-006-0415-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00425-011-1530-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013114109",
"https://doi.org/10.1007/s00425-011-1530-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nprot.2007.95",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029308877",
"https://doi.org/10.1038/nprot.2007.95"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00122-006-0395-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023898230",
"https://doi.org/10.1007/s00122-006-0395-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nbt.1506",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016978514",
"https://doi.org/10.1038/nbt.1506"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11306-011-0369-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000541790",
"https://doi.org/10.1007/s11306-011-0369-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10681-010-0277-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035174032",
"https://doi.org/10.1007/s10681-010-0277-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10059-009-0002-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032381140",
"https://doi.org/10.1007/s10059-009-0002-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1815",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033471111",
"https://doi.org/10.1038/ng1815"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11306-011-0368-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042363301",
"https://doi.org/10.1007/s11306-011-0368-2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00122-009-0980-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052950216",
"https://doi.org/10.1007/s00122-009-0980-y"
],
"type": "CreativeWork"
}
],
"datePublished": "2013-10-23",
"datePublishedReg": "2013-10-23",
"description": "Untargeted LCMS profiling of semi-polar metabolites followed by metabolite quantitative trait locus (mQTL) analysis was performed in ripe pepper fruits of 113 F2 plants derived from a cross between Capsicum annuum AC1979 (no. 19) and Capsicum chinense No. 4661 Selection (no. 18). The parental accessions were selected based on their variation in fruit morphological characteristics and fruit content of some target phytonutrients. Clear segregation of fruit colour and fruit metabolite profiles was observed in the F2 population. The F2 plants formed three clusters based on their metabolite profiles. Of the total of 542 metabolites, 52 could be annotated, including a range of flavonoids, such as flavone C-glycosides, flavonol O-glycosides and naringenin chalcone, as well as several phenylpropanoids, a capsaicin analogue, fatty acid derivatives and amino acid derivatives. Interval mapping revealed 279 mQTLs in total. Two mQTL hotspots were found on chromosome 9. These two chromosomal regions regulated the relative levels of 35 and 103 metabolites, respectively. Analysis also revealed an mQTL for a capsaicin analogue, located on chromosome 7. Confirmation of flavonoid mQTLs using a set of six flavonoid candidate gene markers and their corresponding expression data (expression QTLs) indicated the Ca-MYB12 transcription factor gene on chromosome 1 and the gene encoding flavone synthase (FS-2) on chromosome 6 as likely causative genes determining the variation in naringenin chalcone and flavone C-glycosides, respectively, in this population. The combination of large-scale metabolite profiling and QTL analysis provided valuable insight into the genomic regions and genes important for the production of (secondary) metabolites in pepper fruit. This will impact breeding strategies aimed at optimising the content of specific metabolites in pepper fruit.",
"genre": "article",
"id": "sg:pub.10.1007/s11032-013-9967-0",
"inLanguage": "en",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1114043",
"issn": [
"1380-3743",
"1572-9788"
],
"name": "Molecular Breeding",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "3",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "33"
}
],
"keywords": [
"F2 plants",
"semi-polar metabolites",
"pepper fruits",
"quantitative trait locus (QTL) analysis",
"naringenin chalcone",
"transcription factor genes",
"corresponding expression data",
"quantitative trait loci",
"candidate gene markers",
"ripe pepper fruits",
"large-scale metabolite profiling",
"production of metabolites",
"fruit morphological characteristics",
"flavone synthase",
"metabolite profiles",
"mQTL hotspot",
"parental accessions",
"genetic mapping",
"QTL analysis",
"trait loci",
"genomic regions",
"F2 population",
"molecular regulation",
"breeding strategies",
"interval mapping",
"factor genes",
"chromosomal regions",
"locus analysis",
"chromosome 1",
"MQTLs",
"chromosome 6",
"range of flavonoids",
"chromosome 7",
"gene markers",
"expression data",
"chromosome 9",
"genes",
"fruit color",
"causative genes",
"flavone C-glycosides",
"flavonol O-glycosides",
"metabolite profiling",
"fatty acid derivatives",
"specific metabolites",
"clear segregation",
"relative levels",
"plants",
"morphological characteristics",
"profiling",
"fruit",
"metabolites",
"fruit content",
"accessions",
"loci",
"phenylpropanoids",
"Capsicum",
"valuable insights",
"synthase",
"regulation",
"O-glycosides",
"population",
"cross",
"C-glycosides",
"hotspots",
"region",
"variation",
"amino acid derivatives",
"mapping",
"segregation",
"acid derivatives",
"markers",
"capsaicin analogues",
"insights",
"selection",
"production",
"analysis",
"chalcones",
"profile",
"analogues",
"phytonutrients",
"content",
"clusters",
"flavonoids",
"levels",
"derivatives",
"total",
"combination",
"strategies",
"color",
"range",
"data",
"confirmation",
"set",
"characteristics"
],
"name": "Genetic mapping of semi-polar metabolites in pepper fruits (Capsicum sp.): towards unravelling the molecular regulation of flavonoid quantitative trait loci",
"pagination": "503-518",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1010605700"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s11032-013-9967-0"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"24532977"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s11032-013-9967-0",
"https://app.dimensions.ai/details/publication/pub.1010605700"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-10T10:07",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_613.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s11032-013-9967-0"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11032-013-9967-0'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11032-013-9967-0'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11032-013-9967-0'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11032-013-9967-0'
This table displays all metadata directly associated to this object as RDF triples.
317 TRIPLES
22 PREDICATES
135 URIs
112 LITERALS
7 BLANK NODES