Rapid synthetic approaches to libraries of diversified 1,2-dihydrochromeno[2,3-c]pyrrole-3,9-diones and 3-(2-hydroxyphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-06-04

AUTHORS

Roman N. Vydzhak, Svitlana Ya. Panchishin, Maryna V. Kachaeva, Stepan G. Pilyo, Viktoriia S. Moskvina, Olga V. Shablykina, Andriy V. Kozytskiy, Volodymyr S. Brovarets

ABSTRACT

An efficient and practical synthetic procedure for libraries of diversified 1,2-dihydrochromeno[2,3-c]pyrrole-3,9-diones using a multicomponent process is presented. A convenient synthetic procedure for obtaining functionalized 3-(2-hydroxyphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones via ring-opening strategy has also been developed. This protocol was found to be compatible with a wide range of substituents and paves the way for the practical synthesis of title compounds with a broad range of substituents under mild condition. The products can be easily isolated by crystallization without the use of chromatography.Graphic abstract More... »

PAGES

1115-1128

References to SciGraph publications

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  • 2008-12. Synthesis of 2-alkyl-1-aryl-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione derivatives in RUSSIAN JOURNAL OF GENERAL CHEMISTRY
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  • 2013-10-02. Studies on pyranonigrins–isolation of pyranonigrin E and biosynthetic studies on pyranonigrin A in THE JOURNAL OF ANTIBIOTICS
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/s11030-021-10234-2

    DOI

    http://dx.doi.org/10.1007/s11030-021-10234-2

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34086156


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