Resveratrol protects the brain against oxidative damage in a dopaminergic animal model of mania View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-27

AUTHORS

Samira Menegas, Camila L. Ferreira, José Henrique Cararo, Fernanda F. Gava, Gustavo C. Dal-Pont, Maria L. Gomes, Jotele F. Agostini, Patrícia Fernanda Schuck, Giselli Scaini, Monica L. Andersen, João Quevedo, Samira S. Valvassori

ABSTRACT

The present study aimed to evaluate the effects of resveratrol on behavior and oxidative stress parameters in the brain of rats submitted to the animal model of mania induced by m-AMPH. In the first model (reversal treatment), rats received intraperitoneal (i.p.) injection of saline or m-AMPH (1 mg/kg body weight) once a day for 14 days, and from the 8th to the 14th day, they were orally treated with water or resveratrol (15 mg/kg), once a day. In the second model (maintenance treatment), rats were orally pretreated with water or resveratrol (15 mg/kg) once a day, and from the 8th to the 14th day, they received saline or m-AMPH i.p., once a day. Locomotor and exploratory activities were assessed in the open-field test. Oxidative and nitrosative damage parameters to lipid and proteins were evaluated by TBARS, 4-HNE, carbonyl, and 3-nitrotyrosine in the brain submitted to the experimental models. m-AMPH administration increased the locomotor and exploratory activities; resveratrol was not able to reverse or prevent these manic-like behaviors. Additionally, m-AMPH increased the lipid and protein oxidation and nitrosylation in the frontal cortex, hippocampus, and striatum of rats. However, resveratrol prevented and reversed the oxidative and nitrosative damage to proteins and lipids in all cerebral areas assessed. Since oxidative stress plays an important role in BD pathophysiology, supplementation of resveratrol in BD patients could be regarded as a possible adjunctive treatment with mood stabilizers. More... »

PAGES

941-950

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11011-019-00408-1

DOI

http://dx.doi.org/10.1007/s11011-019-00408-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113047405

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30919245


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antimanic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bipolar Disorder", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Central Nervous System Stimulants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Motor Activity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxidative Stress", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protective Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Wistar", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Resveratrol", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, SC, Brazil", 
          "id": "http://www.grid.ac/institutes/grid.412287.a", 
          "name": [
            "Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, SC, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Menegas", 
        "givenName": "Samira", 
        "id": "sg:person.011246511604.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011246511604.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, SC, Brazil", 
          "id": "http://www.grid.ac/institutes/grid.412287.a", 
          "name": [
            "Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, SC, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ferreira", 
        "givenName": "Camila L.", 
        "id": "sg:person.0615253005.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615253005.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, SC, Brazil", 
          "id": "http://www.grid.ac/institutes/grid.412287.a", 
          "name": [
            "Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, SC, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cararo", 
        "givenName": "Jos\u00e9 Henrique", 
        "id": "sg:person.0676254155.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676254155.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, SC, Brazil", 
          "id": "http://www.grid.ac/institutes/grid.412287.a", 
          "name": [
            "Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, SC, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gava", 
        "givenName": "Fernanda F.", 
        "id": "sg:person.016451502437.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016451502437.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, SC, Brazil", 
          "id": "http://www.grid.ac/institutes/grid.412287.a", 
          "name": [
            "Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, SC, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dal-Pont", 
        "givenName": "Gustavo C.", 
        "id": "sg:person.0721206170.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721206170.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Experimental Neurology Laboratory, Graduate Program in Health Sciences, University of SouthernSanta Catarina (UNESC), Crici\u00fama, SC, Brazil", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Experimental Neurology Laboratory, Graduate Program in Health Sciences, University of SouthernSanta Catarina (UNESC), Crici\u00fama, SC, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gomes", 
        "givenName": "Maria L.", 
        "id": "sg:person.014015555270.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014015555270.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Experimental Neurology Laboratory, Graduate Program in Health Sciences, University of SouthernSanta Catarina (UNESC), Crici\u00fama, SC, Brazil", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Experimental Neurology Laboratory, Graduate Program in Health Sciences, University of SouthernSanta Catarina (UNESC), Crici\u00fama, SC, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Agostini", 
        "givenName": "Jotele F.", 
        "id": "sg:person.013471540007.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013471540007.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Inborn Errors of Metabolism, School of Sciences, Pontifical Catholic University of RioGrande do Sul, Porto Alegre, RS, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Laboratory of Inborn Errors of Metabolism, School of Sciences, Pontifical Catholic University of RioGrande do Sul, Porto Alegre, RS, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schuck", 
        "givenName": "Patr\u00edcia Fernanda", 
        "id": "sg:person.0733353330.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733353330.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.267308.8", 
          "name": [
            "Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scaini", 
        "givenName": "Giselli", 
        "id": "sg:person.01274765574.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274765574.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Psychobiology, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, Brazil", 
          "id": "http://www.grid.ac/institutes/grid.411249.b", 
          "name": [
            "Department of Psychobiology, Federal University of S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Andersen", 
        "givenName": "Monica L.", 
        "id": "sg:person.01131355721.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131355721.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Neuroscience Graduate Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA", 
          "id": "http://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, SC, Brazil", 
            "Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA", 
            "Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA", 
            "Neuroscience Graduate Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Quevedo", 
        "givenName": "Jo\u00e3o", 
        "id": "sg:person.01220221633.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220221633.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, SC, Brazil", 
          "id": "http://www.grid.ac/institutes/grid.412287.a", 
          "name": [
            "Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Crici\u00fama, SC, Brazil"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Valvassori", 
        "givenName": "Samira S.", 
        "id": "sg:person.01061554406.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061554406.34"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00702-011-0691-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027601461", 
          "https://doi.org/10.1007/s00702-011-0691-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13229-018-0225-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105949790", 
          "https://doi.org/10.1186/s13229-018-0225-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00002512-200118090-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024803201", 
          "https://doi.org/10.2165/00002512-200118090-00004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12035-016-9839-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005435373", 
          "https://doi.org/10.1007/s12035-016-9839-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11064-006-9255-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052686052", 
          "https://doi.org/10.1007/s11064-006-9255-z"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-03-27", 
    "datePublishedReg": "2019-03-27", 
    "description": "The present study aimed to evaluate the effects of resveratrol on behavior and oxidative stress parameters in the brain of rats submitted to the animal model of mania induced by m-AMPH. In the first model (reversal treatment), rats received intraperitoneal (i.p.) injection of saline or m-AMPH (1\u00a0mg/kg body weight) once a day for 14\u00a0days, and from the 8th to the 14th day, they were orally treated with water or resveratrol (15\u00a0mg/kg), once a day. In the second model (maintenance treatment), rats were orally pretreated with water or resveratrol (15\u00a0mg/kg) once a day, and from the 8th to the 14th day, they received saline or m-AMPH i.p., once a day. Locomotor and exploratory activities were assessed in the open-field test. Oxidative and nitrosative damage parameters to lipid and proteins were evaluated by TBARS, 4-HNE, carbonyl, and 3-nitrotyrosine in the brain submitted to the experimental models. m-AMPH administration increased the locomotor and exploratory activities; resveratrol was not able to reverse or prevent these manic-like behaviors. Additionally, m-AMPH increased the lipid and protein oxidation and nitrosylation in the frontal cortex, hippocampus, and striatum of rats. However, resveratrol prevented and reversed the oxidative and nitrosative damage to proteins and lipids in all cerebral areas assessed. Since oxidative stress plays an important role in BD pathophysiology, supplementation of resveratrol in BD patients could be regarded as a possible adjunctive treatment with mood stabilizers.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s11011-019-00408-1", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096554", 
        "issn": [
          "0885-7490", 
          "1573-7365"
        ], 
        "name": "Metabolic Brain Disease", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "34"
      }
    ], 
    "keywords": [
      "animal models", 
      "exploratory activity", 
      "supplementation of resveratrol", 
      "possible adjunctive treatment", 
      "brain of rats", 
      "manic-like behavior", 
      "striatum of rats", 
      "effects of resveratrol", 
      "open field test", 
      "oxidative stress parameters", 
      "AMPH administration", 
      "adjunctive treatment", 
      "mood stabilizers", 
      "cerebral areas", 
      "BD patients", 
      "intraperitoneal injection", 
      "frontal cortex", 
      "BD pathophysiology", 
      "rats", 
      "nitrosative damage", 
      "experimental model", 
      "oxidative stress", 
      "AMPH", 
      "resveratrol", 
      "brain", 
      "stress parameters", 
      "oxidative damage", 
      "mania", 
      "days", 
      "saline", 
      "present study", 
      "protein oxidation", 
      "locomotor", 
      "patients", 
      "lipids", 
      "pathophysiology", 
      "hippocampus", 
      "striatum", 
      "cortex", 
      "administration", 
      "damage", 
      "important role", 
      "supplementation", 
      "injection", 
      "TBARS", 
      "treatment", 
      "activity", 
      "protein", 
      "nitrosylation", 
      "study", 
      "role", 
      "test", 
      "effect", 
      "i.", 
      "stress", 
      "model", 
      "area", 
      "parameters", 
      "stabilizer", 
      "behavior", 
      "second model", 
      "first model", 
      "carbonyl", 
      "oxidation", 
      "water", 
      "damage parameters", 
      "AMPH i.", 
      "nitrosative damage parameters", 
      "dopaminergic animal model"
    ], 
    "name": "Resveratrol protects the brain against oxidative damage in a dopaminergic animal model of mania", 
    "pagination": "941-950", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1113047405"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11011-019-00408-1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30919245"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11011-019-00408-1", 
      "https://app.dimensions.ai/details/publication/pub.1113047405"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:45", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_801.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s11011-019-00408-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11011-019-00408-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11011-019-00408-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11011-019-00408-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11011-019-00408-1'


 

This table displays all metadata directly associated to this object as RDF triples.

293 TRIPLES      22 PREDICATES      112 URIs      99 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11011-019-00408-1 schema:about N04e5861923ef4a008f9bb55e020f535e
2 N06a17d20006e4b78a99527a8161b727d
3 N19bae01dc6f145d684de9631f5f6ae9b
4 N3947adaa9e304ee086d7e07ce3800ef2
5 N4122aafb699a42439e95c4fbda8c024f
6 N45d4705ce2f948a7972a193c7b6da065
7 N4aa6cce0abda4bca8edeb7b1372bbe72
8 N7f935de78f254033bee9d686fb1a0b1b
9 N842bb89e6e4f49a78390ada7e61b4da7
10 Nbd069765f65246209d7b128a1f399be5
11 Ncaef68cf515743169ddb7891a06f7a5e
12 Nce3e4eeb0ee549ff8c2008f105cf0aff
13 anzsrc-for:11
14 anzsrc-for:1109
15 schema:author Na9c39cc1159c4b3c89543235c0a72e43
16 schema:citation sg:pub.10.1007/s00702-011-0691-9
17 sg:pub.10.1007/s11064-006-9255-z
18 sg:pub.10.1007/s12035-016-9839-9
19 sg:pub.10.1186/s13229-018-0225-5
20 sg:pub.10.2165/00002512-200118090-00004
21 schema:datePublished 2019-03-27
22 schema:datePublishedReg 2019-03-27
23 schema:description The present study aimed to evaluate the effects of resveratrol on behavior and oxidative stress parameters in the brain of rats submitted to the animal model of mania induced by m-AMPH. In the first model (reversal treatment), rats received intraperitoneal (i.p.) injection of saline or m-AMPH (1 mg/kg body weight) once a day for 14 days, and from the 8th to the 14th day, they were orally treated with water or resveratrol (15 mg/kg), once a day. In the second model (maintenance treatment), rats were orally pretreated with water or resveratrol (15 mg/kg) once a day, and from the 8th to the 14th day, they received saline or m-AMPH i.p., once a day. Locomotor and exploratory activities were assessed in the open-field test. Oxidative and nitrosative damage parameters to lipid and proteins were evaluated by TBARS, 4-HNE, carbonyl, and 3-nitrotyrosine in the brain submitted to the experimental models. m-AMPH administration increased the locomotor and exploratory activities; resveratrol was not able to reverse or prevent these manic-like behaviors. Additionally, m-AMPH increased the lipid and protein oxidation and nitrosylation in the frontal cortex, hippocampus, and striatum of rats. However, resveratrol prevented and reversed the oxidative and nitrosative damage to proteins and lipids in all cerebral areas assessed. Since oxidative stress plays an important role in BD pathophysiology, supplementation of resveratrol in BD patients could be regarded as a possible adjunctive treatment with mood stabilizers.
24 schema:genre article
25 schema:inLanguage en
26 schema:isAccessibleForFree false
27 schema:isPartOf N090a9b9d507e49fcb1b644b00c9b7398
28 Nf073168ee4f24ed0820b158585548b3d
29 sg:journal.1096554
30 schema:keywords AMPH
31 AMPH administration
32 AMPH i.
33 BD pathophysiology
34 BD patients
35 TBARS
36 activity
37 adjunctive treatment
38 administration
39 animal models
40 area
41 behavior
42 brain
43 brain of rats
44 carbonyl
45 cerebral areas
46 cortex
47 damage
48 damage parameters
49 days
50 dopaminergic animal model
51 effect
52 effects of resveratrol
53 experimental model
54 exploratory activity
55 first model
56 frontal cortex
57 hippocampus
58 i.
59 important role
60 injection
61 intraperitoneal injection
62 lipids
63 locomotor
64 mania
65 manic-like behavior
66 model
67 mood stabilizers
68 nitrosative damage
69 nitrosative damage parameters
70 nitrosylation
71 open field test
72 oxidation
73 oxidative damage
74 oxidative stress
75 oxidative stress parameters
76 parameters
77 pathophysiology
78 patients
79 possible adjunctive treatment
80 present study
81 protein
82 protein oxidation
83 rats
84 resveratrol
85 role
86 saline
87 second model
88 stabilizer
89 stress
90 stress parameters
91 striatum
92 striatum of rats
93 study
94 supplementation
95 supplementation of resveratrol
96 test
97 treatment
98 water
99 schema:name Resveratrol protects the brain against oxidative damage in a dopaminergic animal model of mania
100 schema:pagination 941-950
101 schema:productId N63b5adb7dcc9490f97be7974de805a4f
102 N7173c039dd914bc188b9795a85ccc2e7
103 N73bd686c65bd4881a4a7e932ebbc583a
104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113047405
105 https://doi.org/10.1007/s11011-019-00408-1
106 schema:sdDatePublished 2021-12-01T19:45
107 schema:sdLicense https://scigraph.springernature.com/explorer/license/
108 schema:sdPublisher Nccaca25b0b3f4f1eb63ab9d31a2281b6
109 schema:url https://doi.org/10.1007/s11011-019-00408-1
110 sgo:license sg:explorer/license/
111 sgo:sdDataset articles
112 rdf:type schema:ScholarlyArticle
113 N033a51e3b8f44d31ad86550b3166887d rdf:first sg:person.0676254155.78
114 rdf:rest Nd286db5080b648cbbc6a0a4e188610bb
115 N04e5861923ef4a008f9bb55e020f535e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Animals
117 rdf:type schema:DefinedTerm
118 N06a17d20006e4b78a99527a8161b727d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Male
120 rdf:type schema:DefinedTerm
121 N090a9b9d507e49fcb1b644b00c9b7398 schema:volumeNumber 34
122 rdf:type schema:PublicationVolume
123 N19bae01dc6f145d684de9631f5f6ae9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Central Nervous System Stimulants
125 rdf:type schema:DefinedTerm
126 N3158a7091fa24b38a3ba27b6defa013f rdf:first sg:person.014015555270.27
127 rdf:rest N5790aeb50fea4271a187935ff2f2cb68
128 N3947adaa9e304ee086d7e07ce3800ef2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Motor Activity
130 rdf:type schema:DefinedTerm
131 N3fef29ba00094a5388b4a72b29b8aedb rdf:first sg:person.01131355721.01
132 rdf:rest Nbad01e04ab484f25981102980bc5e888
133 N4122aafb699a42439e95c4fbda8c024f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Rats, Wistar
135 rdf:type schema:DefinedTerm
136 N45d4705ce2f948a7972a193c7b6da065 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Protective Agents
138 rdf:type schema:DefinedTerm
139 N4aa6cce0abda4bca8edeb7b1372bbe72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Brain
141 rdf:type schema:DefinedTerm
142 N4b4fabe74de84632a7c253a35900791f rdf:first sg:person.0733353330.99
143 rdf:rest Nc3048a0cb31a4f8fb7d240675d9731a5
144 N5790aeb50fea4271a187935ff2f2cb68 rdf:first sg:person.013471540007.68
145 rdf:rest N4b4fabe74de84632a7c253a35900791f
146 N63b5adb7dcc9490f97be7974de805a4f schema:name pubmed_id
147 schema:value 30919245
148 rdf:type schema:PropertyValue
149 N7173c039dd914bc188b9795a85ccc2e7 schema:name doi
150 schema:value 10.1007/s11011-019-00408-1
151 rdf:type schema:PropertyValue
152 N73bd686c65bd4881a4a7e932ebbc583a schema:name dimensions_id
153 schema:value pub.1113047405
154 rdf:type schema:PropertyValue
155 N7f935de78f254033bee9d686fb1a0b1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Disease Models, Animal
157 rdf:type schema:DefinedTerm
158 N842bb89e6e4f49a78390ada7e61b4da7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Bipolar Disorder
160 rdf:type schema:DefinedTerm
161 N95374e39d2ca4d9a910d476f33047421 rdf:first sg:person.01061554406.34
162 rdf:rest rdf:nil
163 Na9c39cc1159c4b3c89543235c0a72e43 rdf:first sg:person.011246511604.75
164 rdf:rest Nf70e42b3f120458ba3127bc020740bbe
165 Na9d990eb2c4046dea8f4908efe24ff84 rdf:first sg:person.0721206170.69
166 rdf:rest N3158a7091fa24b38a3ba27b6defa013f
167 Nbad01e04ab484f25981102980bc5e888 rdf:first sg:person.01220221633.34
168 rdf:rest N95374e39d2ca4d9a910d476f33047421
169 Nbd069765f65246209d7b128a1f399be5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Resveratrol
171 rdf:type schema:DefinedTerm
172 Nc3048a0cb31a4f8fb7d240675d9731a5 rdf:first sg:person.01274765574.17
173 rdf:rest N3fef29ba00094a5388b4a72b29b8aedb
174 Ncaef68cf515743169ddb7891a06f7a5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Antimanic Agents
176 rdf:type schema:DefinedTerm
177 Nccaca25b0b3f4f1eb63ab9d31a2281b6 schema:name Springer Nature - SN SciGraph project
178 rdf:type schema:Organization
179 Nce3e4eeb0ee549ff8c2008f105cf0aff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Oxidative Stress
181 rdf:type schema:DefinedTerm
182 Nd286db5080b648cbbc6a0a4e188610bb rdf:first sg:person.016451502437.04
183 rdf:rest Na9d990eb2c4046dea8f4908efe24ff84
184 Nf073168ee4f24ed0820b158585548b3d schema:issueNumber 3
185 rdf:type schema:PublicationIssue
186 Nf70e42b3f120458ba3127bc020740bbe rdf:first sg:person.0615253005.44
187 rdf:rest N033a51e3b8f44d31ad86550b3166887d
188 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
189 schema:name Medical and Health Sciences
190 rdf:type schema:DefinedTerm
191 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
192 schema:name Neurosciences
193 rdf:type schema:DefinedTerm
194 sg:journal.1096554 schema:issn 0885-7490
195 1573-7365
196 schema:name Metabolic Brain Disease
197 schema:publisher Springer Nature
198 rdf:type schema:Periodical
199 sg:person.01061554406.34 schema:affiliation grid-institutes:grid.412287.a
200 schema:familyName Valvassori
201 schema:givenName Samira S.
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061554406.34
203 rdf:type schema:Person
204 sg:person.011246511604.75 schema:affiliation grid-institutes:grid.412287.a
205 schema:familyName Menegas
206 schema:givenName Samira
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011246511604.75
208 rdf:type schema:Person
209 sg:person.01131355721.01 schema:affiliation grid-institutes:grid.411249.b
210 schema:familyName Andersen
211 schema:givenName Monica L.
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131355721.01
213 rdf:type schema:Person
214 sg:person.01220221633.34 schema:affiliation grid-institutes:grid.240145.6
215 schema:familyName Quevedo
216 schema:givenName João
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220221633.34
218 rdf:type schema:Person
219 sg:person.01274765574.17 schema:affiliation grid-institutes:grid.267308.8
220 schema:familyName Scaini
221 schema:givenName Giselli
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274765574.17
223 rdf:type schema:Person
224 sg:person.013471540007.68 schema:affiliation grid-institutes:None
225 schema:familyName Agostini
226 schema:givenName Jotele F.
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013471540007.68
228 rdf:type schema:Person
229 sg:person.014015555270.27 schema:affiliation grid-institutes:None
230 schema:familyName Gomes
231 schema:givenName Maria L.
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014015555270.27
233 rdf:type schema:Person
234 sg:person.016451502437.04 schema:affiliation grid-institutes:grid.412287.a
235 schema:familyName Gava
236 schema:givenName Fernanda F.
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016451502437.04
238 rdf:type schema:Person
239 sg:person.0615253005.44 schema:affiliation grid-institutes:grid.412287.a
240 schema:familyName Ferreira
241 schema:givenName Camila L.
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615253005.44
243 rdf:type schema:Person
244 sg:person.0676254155.78 schema:affiliation grid-institutes:grid.412287.a
245 schema:familyName Cararo
246 schema:givenName José Henrique
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676254155.78
248 rdf:type schema:Person
249 sg:person.0721206170.69 schema:affiliation grid-institutes:grid.412287.a
250 schema:familyName Dal-Pont
251 schema:givenName Gustavo C.
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721206170.69
253 rdf:type schema:Person
254 sg:person.0733353330.99 schema:affiliation grid-institutes:None
255 schema:familyName Schuck
256 schema:givenName Patrícia Fernanda
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733353330.99
258 rdf:type schema:Person
259 sg:pub.10.1007/s00702-011-0691-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027601461
260 https://doi.org/10.1007/s00702-011-0691-9
261 rdf:type schema:CreativeWork
262 sg:pub.10.1007/s11064-006-9255-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1052686052
263 https://doi.org/10.1007/s11064-006-9255-z
264 rdf:type schema:CreativeWork
265 sg:pub.10.1007/s12035-016-9839-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005435373
266 https://doi.org/10.1007/s12035-016-9839-9
267 rdf:type schema:CreativeWork
268 sg:pub.10.1186/s13229-018-0225-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105949790
269 https://doi.org/10.1186/s13229-018-0225-5
270 rdf:type schema:CreativeWork
271 sg:pub.10.2165/00002512-200118090-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024803201
272 https://doi.org/10.2165/00002512-200118090-00004
273 rdf:type schema:CreativeWork
274 grid-institutes:None schema:alternateName Experimental Neurology Laboratory, Graduate Program in Health Sciences, University of SouthernSanta Catarina (UNESC), Criciúma, SC, Brazil
275 Laboratory of Inborn Errors of Metabolism, School of Sciences, Pontifical Catholic University of RioGrande do Sul, Porto Alegre, RS, USA
276 schema:name Experimental Neurology Laboratory, Graduate Program in Health Sciences, University of SouthernSanta Catarina (UNESC), Criciúma, SC, Brazil
277 Laboratory of Inborn Errors of Metabolism, School of Sciences, Pontifical Catholic University of RioGrande do Sul, Porto Alegre, RS, USA
278 rdf:type schema:Organization
279 grid-institutes:grid.240145.6 schema:alternateName Neuroscience Graduate Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA
280 schema:name Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA
281 Neuroscience Graduate Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA
282 Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil
283 Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA
284 rdf:type schema:Organization
285 grid-institutes:grid.267308.8 schema:alternateName Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA
286 schema:name Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA
287 rdf:type schema:Organization
288 grid-institutes:grid.411249.b schema:alternateName Department of Psychobiology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil
289 schema:name Department of Psychobiology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil
290 rdf:type schema:Organization
291 grid-institutes:grid.412287.a schema:alternateName Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil
292 schema:name Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil
293 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...