Antioxidant effects of rice bran oil mitigate repeated haloperidol-induced tardive dyskinesia in male rats View Full Text


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Article Info

DATE

2017-04-03

AUTHORS

Noreen Samad, Darakhshan Jabeen Haleem

ABSTRACT

Tardive dyskinesia (TD) is associated with the use of antipsychotic drugs such as D2 antagonist haloperidol (HP). The chronic use of HP is involved in the causation of free radicals and/or oxidative stress. In view of the nootropic, anti-anxiety, anti-inflammatory-like effects of rice bran oil (RBO) in a variety of investigations, we assessed the protective properties of RBO on HP-induced TD and neurochemical alteration. Rats treated with HP orally at a dose of 0.2 mg/kg/day for a period of 5 weeks developed VCMs which increased progressively as the treatment continued for 5 weeks. Co-administration of RBO by oral tubes at a dose of 0.4 ml/day prevented the induction of HP-induced VCMs. Repeated administration of HP increases the turnover of dopamine metabolism in the striatum. Conversely animals treated with HP + RBO decrease the metabolism of DA than water + HP treated animals. Striatal, malondieldehyde (MDA), hydrogen peroxide (H2O2) and antioxidant enzyme superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were also determined. It is suggested that beneficial role of RBO in attenuation of HP-induced TD. The results therefore recommended that supplementation of RBO may be useful in the HP-induced TD. The findings have also potential implication in the treatment of schizophrenia and motor disorders. More... »

PAGES

1099-1107

References to SciGraph publications

  • 1988. Hydrogen Peroxide Production in Dopamine Neurons in OXYGEN RADICALS IN BIOLOGY AND MEDICINE
  • 2005-01. Repeated Restraint Stress Induces Oxidative Damage in Rat Hippocampus in NEUROCHEMICAL RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11011-017-0002-8

    DOI

    http://dx.doi.org/10.1007/s11011-017-0002-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1084510908

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28374238


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