Ontology type: schema:ScholarlyArticle
2015-11-12
AUTHORSGeorg Oeltzschner, Markus Butz, Frithjof Wickrath, Hans-Jörg Wittsack, Alfons Schnitzler
ABSTRACTRecent pathophysiological models suggest that oxidative stress and hyperammonemia lead to a mild brain oedema in hepatic encephalopathy (HE). Glutathione (GSx) is a major cellular antioxidant and known to be involved in the interception of both. The aim of this work was to study total glutathione levels in covert HE (minimal HE and HE grade 1) and to investigate their relationship with local brain water content, levels of glutamine (Gln), myo-inositol (mI), neurotransmitter levels, critical flicker frequency (CFF), and blood ammonia. Proton magnetic resonance spectroscopy (1H MRS) data were analysed from visual and sensorimotor cortices of thirty patients with covert HE and 16 age-matched healthy controls. Total glutathione levels (GSx/Cr) were quantified with respect to creatine. Furthermore, quantitative MRI brain water content measures were evaluated. Data were tested for links with the CFF and blood ammonia. GSx/Cr was elevated in the visual (mHE) and sensorimotor (mHE, HE 1) MRS volumes and correlated with blood ammonia levels (both P < 0.001). It was further linked to Gln/Cr and mI/Cr (P < 0.01 in visual, P < 0.001 in sensorimotor) and to GABA/Cr (P < 0.01 in visual). Visual GSx/Cr correlated with brain water content in the thalamus, nucleus caudatus, and visual cortex (P < 0.01). Brain water measures did neither show group effects nor correlations with CFF or blood ammonia. Elevated total glutathione levels in covert HE (< HE 2) correlate with blood ammonia and may be a regional-specific reaction to hyperammonemia and oxidative stress. Brain water content is locally linked to visual glutathione levels, but appears not to be associated with changes of clinical parameters. This might suggest that cerebral oedema is only marginally responsible for the symptoms of covert HE. More... »
PAGES517-527
http://scigraph.springernature.com/pub.10.1007/s11011-015-9760-3
DOIhttp://dx.doi.org/10.1007/s11011-015-9760-3
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1001719019
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/26563124
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Neurosciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ammonia",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Brain",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Brain Edema",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Creatine",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Glutathione",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hepatic Encephalopathy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Magnetic Resonance Spectroscopy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Oxidative Stress",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Water",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Diagnostic and Interventional Radiology, Medical Faculty, Heinrich-Heine-University D\u00fcsseldorf, D-40225, D\u00fcsseldorf, Germany",
"id": "http://www.grid.ac/institutes/grid.411327.2",
"name": [
"Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University D\u00fcsseldorf, Universit\u00e4tsstr. 1, D-40225, D\u00fcsseldorf, Germany",
"Department of Diagnostic and Interventional Radiology, Medical Faculty, Heinrich-Heine-University D\u00fcsseldorf, D-40225, D\u00fcsseldorf, Germany"
],
"type": "Organization"
},
"familyName": "Oeltzschner",
"givenName": "Georg",
"id": "sg:person.01124320546.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124320546.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University D\u00fcsseldorf, Universit\u00e4tsstr. 1, D-40225, D\u00fcsseldorf, Germany",
"id": "http://www.grid.ac/institutes/grid.411327.2",
"name": [
"Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University D\u00fcsseldorf, Universit\u00e4tsstr. 1, D-40225, D\u00fcsseldorf, Germany"
],
"type": "Organization"
},
"familyName": "Butz",
"givenName": "Markus",
"id": "sg:person.01173636043.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173636043.35"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Diagnostic and Interventional Radiology, Medical Faculty, Heinrich-Heine-University D\u00fcsseldorf, D-40225, D\u00fcsseldorf, Germany",
"id": "http://www.grid.ac/institutes/grid.411327.2",
"name": [
"Department of Diagnostic and Interventional Radiology, Medical Faculty, Heinrich-Heine-University D\u00fcsseldorf, D-40225, D\u00fcsseldorf, Germany"
],
"type": "Organization"
},
"familyName": "Wickrath",
"givenName": "Frithjof",
"id": "sg:person.01175241560.55",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175241560.55"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Diagnostic and Interventional Radiology, Medical Faculty, Heinrich-Heine-University D\u00fcsseldorf, D-40225, D\u00fcsseldorf, Germany",
"id": "http://www.grid.ac/institutes/grid.411327.2",
"name": [
"Department of Diagnostic and Interventional Radiology, Medical Faculty, Heinrich-Heine-University D\u00fcsseldorf, D-40225, D\u00fcsseldorf, Germany"
],
"type": "Organization"
},
"familyName": "Wittsack",
"givenName": "Hans-J\u00f6rg",
"id": "sg:person.0675141725.09",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675141725.09"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University D\u00fcsseldorf, Universit\u00e4tsstr. 1, D-40225, D\u00fcsseldorf, Germany",
"id": "http://www.grid.ac/institutes/grid.411327.2",
"name": [
"Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University D\u00fcsseldorf, Universit\u00e4tsstr. 1, D-40225, D\u00fcsseldorf, Germany"
],
"type": "Organization"
},
"familyName": "Schnitzler",
"givenName": "Alfons",
"id": "sg:person.0712546530.93",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712546530.93"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s11064-006-9265-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028327427",
"https://doi.org/10.1007/s11064-006-9265-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00330-013-2963-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034303830",
"https://doi.org/10.1007/s00330-013-2963-2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/npp.2011.20",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048058454",
"https://doi.org/10.1038/npp.2011.20"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11011-015-9729-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006676689",
"https://doi.org/10.1007/s11011-015-9729-2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11011-014-9573-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052089061",
"https://doi.org/10.1007/s11011-014-9573-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrn3587",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044292335",
"https://doi.org/10.1038/nrn3587"
],
"type": "CreativeWork"
}
],
"datePublished": "2015-11-12",
"datePublishedReg": "2015-11-12",
"description": "Recent pathophysiological models suggest that oxidative stress and hyperammonemia lead to a mild brain oedema in hepatic encephalopathy (HE). Glutathione (GSx) is a major cellular antioxidant and known to be involved in the interception of both. The aim of this work was to study total glutathione levels in covert HE (minimal HE and HE grade 1) and to investigate their relationship with local brain water content, levels of glutamine (Gln), myo-inositol (mI), neurotransmitter levels, critical flicker frequency (CFF), and blood ammonia. Proton magnetic resonance spectroscopy (1H MRS) data were analysed from visual and sensorimotor cortices of thirty patients with covert HE and 16 age-matched healthy controls. Total glutathione levels (GSx/Cr) were quantified with respect to creatine. Furthermore, quantitative MRI brain water content measures were evaluated. Data were tested for links with the CFF and blood ammonia. GSx/Cr was elevated in the visual (mHE) and sensorimotor (mHE, HE 1) MRS volumes and correlated with blood ammonia levels (both P\u00a0<\u00a00.001). It was further linked to Gln/Cr and mI/Cr (P\u00a0<\u00a00.01 in visual, P\u00a0<\u00a00.001 in sensorimotor) and to GABA/Cr (P\u00a0<\u00a00.01 in visual). Visual GSx/Cr correlated with brain water content in the thalamus, nucleus caudatus, and visual cortex (P\u00a0<\u00a00.01). Brain water measures did neither show group effects nor correlations with CFF or blood ammonia. Elevated total glutathione levels in covert HE (< HE 2) correlate with blood ammonia and may be a regional-specific reaction to hyperammonemia and oxidative stress. Brain water content is locally linked to visual glutathione levels, but appears not to be associated with changes of clinical parameters. This might suggest that cerebral oedema is only marginally responsible for the symptoms of covert HE.",
"genre": "article",
"id": "sg:pub.10.1007/s11011-015-9760-3",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1096554",
"issn": [
"0885-7490",
"1573-7365"
],
"name": "Metabolic Brain Disease",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "3",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "31"
}
],
"keywords": [
"brain water content",
"critical flicker frequency",
"Covert Hepatic Encephalopathy",
"total glutathione levels",
"hepatic encephalopathy",
"blood ammonia",
"glutathione levels",
"age-matched healthy controls",
"oxidative stress",
"mild brain edema",
"blood ammonia levels",
"mI/Cr",
"Gln/Cr",
"GABA/Cr",
"cerebral edema",
"levels of glutamine",
"brain edema",
"proton magnetic resonance spectroscopy data",
"clinical parameters",
"sensorimotor cortex",
"nucleus caudatus",
"neurotransmitter levels",
"healthy controls",
"pathophysiological model",
"visual cortex",
"major cellular antioxidant",
"MRS volume",
"total glutathione",
"ammonia levels",
"edema",
"flicker frequency",
"cellular antioxidants",
"cortex",
"magnetic resonance spectroscopy data",
"myo-inositol",
"group effects",
"glutathione",
"levels",
"patients",
"thalamus",
"encephalopathy",
"hyperammonemia",
"symptoms",
"creatine",
"antioxidants",
"measures",
"correlates",
"aim",
"changes",
"glutamine",
"stress",
"data",
"absence",
"control",
"caudatus",
"correlation",
"effect",
"volume",
"water measures",
"frequency",
"relationship",
"lead",
"content",
"Cr",
"link",
"reaction",
"visuals",
"model",
"respect",
"content measures",
"content changes",
"parameters",
"water content",
"ammonia",
"work",
"water content changes",
"interception",
"spectroscopy data"
],
"name": "Covert hepatic encephalopathy: elevated total glutathione and absence of brain water content changes",
"pagination": "517-527",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1001719019"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s11011-015-9760-3"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"26563124"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s11011-015-9760-3",
"https://app.dimensions.ai/details/publication/pub.1001719019"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T17:04",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_679.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s11011-015-9760-3"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11011-015-9760-3'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11011-015-9760-3'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11011-015-9760-3'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11011-015-9760-3'
This table displays all metadata directly associated to this object as RDF triples.
249 TRIPLES
21 PREDICATES
123 URIs
109 LITERALS
21 BLANK NODES