Altered metal metabolism in patients with HCV-related cirrhosis and hepatic encephalopathy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-08-27

AUTHORS

Massimo Marano, Umberto Vespasiani Gentilucci, Claudia Altamura, Mariacristina Siotto, Rosanna Squitti, Serena Bucossi, Livia Quintiliani, Simone Migliore, Federico Greco, Laura Scarciolla, Carlo Cosimo Quattrocchi, Antonio Picardi, Fabrizio Vernieri

ABSTRACT

Dysfunctional metal homeostasis contributes to oxidative stress and neuronal damage. These have been implicated in hepatic encephalopathy pathogenesis. To investigate whether altered metal metabolism is associated with hepatic encephalopathy. Twenty-one controls and 34 HCV-cirrhotic patients (ENC/NEC patients according to presence/absence of previous overt episodes of hepatic encephalopathy) and a control group were studied. Serum iron, copper, ceruloplasmin, ceruloplasmin activity, transferrin, and ceruloplasmin/transferrin ratio were determined. Neuropsychological tests were performed by the repeatable battery of neuropsychological status. Magnetic resonance assessed basal ganglia volumes and metal deposition (pallidal index and T2*). Cirrhotic patients performed worse than controls at cognitive tests, especially ENC patients,. At biochemical analysis copper concentrations, ceruloplasmin activity and transferrin levels were lower in ENC than in NEC patients and controls (p < 0.05 and p < 0.01, respectively). Ceruloplasmin/transferrin ratio was higher in ENC compared to NEC patients (p < 0.05), and controls (p < 0.01). By brain magnetic resonance, ENC patients showed reduced caudate and globus pallidus volumes compared to controls (p < 0.05), and ENC and NEC patients an increased pallidal index compared to controls (p < 0.01). In ENC patients, ceruloplasmin activity correlated with caudate volume and pallidal index (ρ = 0.773 and ρ = −0.683, p < 0.05). Altered metal metabolism likely contributes to cirrhotic hepatic encephalopathy. More... »

PAGES

1445-1452

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    http://scigraph.springernature.com/pub.10.1007/s11011-015-9721-x

    DOI

    http://dx.doi.org/10.1007/s11011-015-9721-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1015393651

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26307419


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