HGF promotes HTR-8/SVneo cell migration through activation of MAPK/PKA signaling leading to up-regulation of WNT ligands and integrins that target ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

Piyush Chaudhary, Sudha Saryu Malhotra, Gosipatala Sunil Babu, Ranbir Chander Sobti, Satish Kumar Gupta

ABSTRACT

Inadequate migration and invasion of the trophoblast cells during embryo implantation is one of the reasons for pregnancy-related complications such as intrauterine growth restriction and preeclampsia. In the present study, relevance of WNT ligands and integrins associated with hepatocyte growth factor (HGF)-mediated migration of HTR-8/SVneo trophoblastic cells has been investigated. Treatment of HTR-8/SVneo cells with HGF led to a dose-dependent increase in their migration. RT-PCR studies revealed a significant increase in the transcripts of WNT4, WNT11, ITGA2, and ITGAV, which was further confirmed at protein level by Western blotting. HGF treatment also led to increased expression of integrin α2β1 and αVβ5 in HTR-8/SVneo cells. Silencing of WNT4, WNT11, ITGA2, and ITGAV by siRNA led to a significant decrease in HGF-mediated migration of cells. Treatment of cells with HGF led to activation of mitogen-activated protein kinases (MAPK) and protein kinase A (PKA) signaling pathways. Inhibition of MAPK/PKA, by selective inhibitors, led to decrease in the expression of above WNT ligands and integrins. Silencing of WNT4/WNT11 led to concomitant decrease in the expression of ITGA2 and ITGAV and vice versa. HGF treatment also led to significant increase in β-catenin expression, a downstream target of both WNT ligands and integrins. Silencing of β-catenin led to decrease in HGF-mediated migration. β-catenin expression was also down-regulated in WNT4/WNT11/ITGA2/ITGAV silenced cells suggesting a possible cross-communication of WNT ligands and integrins via β-catenin. These studies have established the significance of WNT4/WNT11 as well as ITGA2/ITGAV during HGF-mediated migration of HTR-8/SVneo trophoblastic cells. More... »

PAGES

11-32

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11010-018-3428-3

DOI

http://dx.doi.org/10.1007/s11010-018-3428-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1106284298

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30136190


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Paediatrics and Reproductive Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Movement", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclic AMP-Dependent Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Extracellular Signal-Regulated MAP Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hepatocyte Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Integrins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MAP Kinase Signaling System", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trophoblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wnt Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wnt4 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "beta Catenin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Babasaheb Bhimrao Ambedkar University", 
          "id": "https://www.grid.ac/institutes/grid.440550.0", 
          "name": [
            "Reproductive Cell Biology Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, 110 067, New Delhi, India", 
            "Department of Biotechnology, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, 226 025, Lucknow, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chaudhary", 
        "givenName": "Piyush", 
        "id": "sg:person.01163572543.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163572543.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Immunology", 
          "id": "https://www.grid.ac/institutes/grid.19100.39", 
          "name": [
            "Reproductive Cell Biology Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, 110 067, New Delhi, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Malhotra", 
        "givenName": "Sudha Saryu", 
        "id": "sg:person.01222554642.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222554642.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Babasaheb Bhimrao Ambedkar University", 
          "id": "https://www.grid.ac/institutes/grid.440550.0", 
          "name": [
            "Department of Biotechnology, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, 226 025, Lucknow, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Babu", 
        "givenName": "Gosipatala Sunil", 
        "id": "sg:person.010544171076.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010544171076.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Babasaheb Bhimrao Ambedkar University", 
          "id": "https://www.grid.ac/institutes/grid.440550.0", 
          "name": [
            "Babasaheb Bhimrao Ambedkar University, Vidya Vihar, 226 025, Lucknow, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sobti", 
        "givenName": "Ranbir Chander", 
        "id": "sg:person.01257222503.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257222503.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Immunology", 
          "id": "https://www.grid.ac/institutes/grid.19100.39", 
          "name": [
            "Reproductive Cell Biology Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, 110 067, New Delhi, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gupta", 
        "givenName": "Satish Kumar", 
        "id": "sg:person.016552034474.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016552034474.23"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1155/2015/201629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000665530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.placenta.2014.04.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002135428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0007841", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004264883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jri.2009.07.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004619333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200206011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007283814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(92)90115-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007440282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m200187200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008166034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/rep-10-0294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008302339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6603088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008884427", 
          "https://doi.org/10.1038/sj.bjc.6603088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6603088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008884427", 
          "https://doi.org/10.1038/sj.bjc.6603088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.12-217083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009296134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.01601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009457939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.placenta.2013.06.311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009792818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1758834011422556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011306841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1758834011422556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011306841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m305312200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011758444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.2000.3252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012048237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2012.01.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012684402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddv621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012704858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e08-06-0569", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014532764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1095/biolreprod.109.078634", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014779331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci119388", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017050821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)65658-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017143390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.00821", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018378497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m010669200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018390952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.placenta.2006.11.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019246045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1078/0065-1281-00708", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019949234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1078/0065-1281-00708", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019949234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-0226", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019964423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.21.12851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021334841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.142.4.1145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021990625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/excr.1993.1139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022743133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m113.523746", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022901887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexcr.2006.09.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023463046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11373-005-9061-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025235845", 
          "https://doi.org/10.1007/s11373-005-9061-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11373-005-9061-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025235845", 
          "https://doi.org/10.1007/s11373-005-9061-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.90.5.1937", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026126708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.21932", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029018977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.21932", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029018977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci115565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030161607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.00443-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030772685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9378(95)90370-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031807598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0143-4004(83)80043-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032822674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.027805", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033362510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/humupd/2.4.307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033583105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbamcr.2013.09.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033764056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1477-7827-10-83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034514120", 
          "https://doi.org/10.1186/1477-7827-10-83"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/humupd/dml048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036227173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1541-7786.mcr-09-0238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036941409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci116316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038305490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jat.3227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038855098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m402877200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041310896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/1523-1747.ep12472299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041466680", 
          "https://doi.org/10.1111/1523-1747.ep12472299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.00591", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042791693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5734/jgm.2012.9.2.78", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042850920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep20395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045208198", 
          "https://doi.org/10.1038/srep20395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)80043-e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045209738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/373702a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045696614", 
          "https://doi.org/10.1038/373702a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-010-0111-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046104627", 
          "https://doi.org/10.1007/s11060-010-0111-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-010-0111-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046104627", 
          "https://doi.org/10.1007/s11060-010-0111-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1998.8888", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048480914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10585-011-9404-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050003841", 
          "https://doi.org/10.1007/s10585-011-9404-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/excr.2002.5616", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050410967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/excr.1995.1105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050939224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/plac.2001.0647", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051875656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m114.563213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051908524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2009-0557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052066616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0028-1108011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057123639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2002-220886", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064245871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/mmr.2014.1937", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071521481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/mmr.2014.1937", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071521481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ol.2015.3943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071526766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074486523", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076866321", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077464092", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077620784", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077651513", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082400416", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082443759", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082800914", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083186068", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-03", 
    "datePublishedReg": "2019-03-01", 
    "description": "Inadequate migration and invasion of the trophoblast cells during embryo implantation is one of the reasons for pregnancy-related complications such as intrauterine growth restriction and preeclampsia. In the present study, relevance of WNT ligands and integrins associated with hepatocyte growth factor (HGF)-mediated migration of HTR-8/SVneo trophoblastic cells has been investigated. Treatment of HTR-8/SVneo cells with HGF led to a dose-dependent increase in their migration. RT-PCR studies revealed a significant increase in the transcripts of WNT4, WNT11, ITGA2, and ITGAV, which was further confirmed at protein level by Western blotting. HGF treatment also led to increased expression of integrin \u03b12\u03b21 and \u03b1V\u03b25 in HTR-8/SVneo cells. Silencing of WNT4, WNT11, ITGA2, and ITGAV by siRNA led to a significant decrease in HGF-mediated migration of cells. Treatment of cells with HGF led to activation of mitogen-activated protein kinases (MAPK) and protein kinase A (PKA) signaling pathways. Inhibition of MAPK/PKA, by selective inhibitors, led to decrease in the expression of above WNT ligands and integrins. Silencing of WNT4/WNT11 led to concomitant decrease in the expression of ITGA2 and ITGAV and vice versa. HGF treatment also led to significant increase in \u03b2-catenin expression, a downstream target of both WNT ligands and integrins. Silencing of \u03b2-catenin led to decrease in HGF-mediated migration. \u03b2-catenin expression was also down-regulated in WNT4/WNT11/ITGA2/ITGAV silenced cells suggesting a possible cross-communication of WNT ligands and integrins via \u03b2-catenin. These studies have established the significance of WNT4/WNT11 as well as ITGA2/ITGAV during HGF-mediated migration of HTR-8/SVneo trophoblastic cells.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11010-018-3428-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1016672", 
        "issn": [
          "0300-8177", 
          "1573-4919"
        ], 
        "name": "Molecular and Cellular Biochemistry", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1-2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "453"
      }
    ], 
    "name": "HGF promotes HTR-8/SVneo cell migration through activation of MAPK/PKA signaling leading to up-regulation of WNT ligands and integrins that target \u03b2-catenin", 
    "pagination": "11-32", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "22f23b430fec2097e9bc9a999a8d9685e3a69be2ed88b50c820c279fc3b7a20f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30136190"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0364456"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11010-018-3428-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1106284298"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11010-018-3428-3", 
      "https://app.dimensions.ai/details/publication/pub.1106284298"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54338_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs11010-018-3428-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11010-018-3428-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11010-018-3428-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11010-018-3428-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11010-018-3428-3'


 

This table displays all metadata directly associated to this object as RDF triples.

371 TRIPLES      21 PREDICATES      115 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11010-018-3428-3 schema:about N0541b527a1124125b9429216c67ae973
2 N35978a9ec03143119a65edc4d23bff4c
3 N77476047699b4169a2d544d2d4ca215b
4 N7ab0f2a7e1f24a5fae1cbeb849e65432
5 N8d1677266637493299a982693ff62196
6 Na54a1aab4f9844449b3f1a2ca6a0c14c
7 Nadae40c32fa7498a87d7cd64b441f153
8 Nc7588ac258e048baa5ea6da4b941883e
9 Ndd4478996eb14a95acc3a50b5ff3a92f
10 Ne48685228ecc443f8411322b038d56f3
11 Ne8033e5bb50849819db299384ed1ea8b
12 Nea22fff93bed4529ad3441558c666afb
13 anzsrc-for:11
14 anzsrc-for:1114
15 schema:author N2235b40a42084ab0b72a1598c446db5e
16 schema:citation sg:pub.10.1007/s10585-011-9404-x
17 sg:pub.10.1007/s11060-010-0111-2
18 sg:pub.10.1007/s11373-005-9061-7
19 sg:pub.10.1038/373702a0
20 sg:pub.10.1038/sj.bjc.6603088
21 sg:pub.10.1038/srep20395
22 sg:pub.10.1111/1523-1747.ep12472299
23 sg:pub.10.1186/1477-7827-10-83
24 https://app.dimensions.ai/details/publication/pub.1074486523
25 https://app.dimensions.ai/details/publication/pub.1076866321
26 https://app.dimensions.ai/details/publication/pub.1077464092
27 https://app.dimensions.ai/details/publication/pub.1077620784
28 https://app.dimensions.ai/details/publication/pub.1077651513
29 https://app.dimensions.ai/details/publication/pub.1082400416
30 https://app.dimensions.ai/details/publication/pub.1082443759
31 https://app.dimensions.ai/details/publication/pub.1082800914
32 https://app.dimensions.ai/details/publication/pub.1083186068
33 https://doi.org/10.1002/jat.3227
34 https://doi.org/10.1002/jcp.21932
35 https://doi.org/10.1006/bbrc.1998.8888
36 https://doi.org/10.1006/bbrc.2000.3252
37 https://doi.org/10.1006/excr.1993.1139
38 https://doi.org/10.1006/excr.1995.1105
39 https://doi.org/10.1006/excr.2002.5616
40 https://doi.org/10.1016/0002-9378(95)90370-4
41 https://doi.org/10.1016/0092-8674(92)90115-s
42 https://doi.org/10.1016/0092-8674(93)80043-e
43 https://doi.org/10.1016/j.bbamcr.2013.09.020
44 https://doi.org/10.1016/j.jri.2009.07.002
45 https://doi.org/10.1016/j.placenta.2006.11.003
46 https://doi.org/10.1016/j.placenta.2013.06.311
47 https://doi.org/10.1016/j.placenta.2014.04.011
48 https://doi.org/10.1016/j.ydbio.2012.01.014
49 https://doi.org/10.1016/j.yexcr.2006.09.018
50 https://doi.org/10.1016/s0002-9440(10)65658-1
51 https://doi.org/10.1016/s0143-4004(83)80043-5
52 https://doi.org/10.1053/plac.2001.0647
53 https://doi.org/10.1055/s-0028-1108011
54 https://doi.org/10.1073/pnas.90.5.1937
55 https://doi.org/10.1074/jbc.270.21.12851
56 https://doi.org/10.1074/jbc.m010669200
57 https://doi.org/10.1074/jbc.m113.523746
58 https://doi.org/10.1074/jbc.m114.563213
59 https://doi.org/10.1074/jbc.m200187200
60 https://doi.org/10.1074/jbc.m305312200
61 https://doi.org/10.1074/jbc.m402877200
62 https://doi.org/10.1078/0065-1281-00708
63 https://doi.org/10.1083/jcb.142.4.1145
64 https://doi.org/10.1083/jcb.200206011
65 https://doi.org/10.1091/mbc.e08-06-0569
66 https://doi.org/10.1093/hmg/ddv621
67 https://doi.org/10.1093/humupd/2.4.307
68 https://doi.org/10.1093/humupd/dml048
69 https://doi.org/10.1095/biolreprod.109.078634
70 https://doi.org/10.1096/fj.12-217083
71 https://doi.org/10.1128/mcb.00443-07
72 https://doi.org/10.1155/2015/201629
73 https://doi.org/10.1158/0008-5472.can-10-0226
74 https://doi.org/10.1158/1541-7786.mcr-09-0238
75 https://doi.org/10.1172/jci115565
76 https://doi.org/10.1172/jci116316
77 https://doi.org/10.1172/jci119388
78 https://doi.org/10.1177/1758834011422556
79 https://doi.org/10.1210/en.2002-220886
80 https://doi.org/10.1210/en.2009-0557
81 https://doi.org/10.1242/dev.00591
82 https://doi.org/10.1242/dev.00821
83 https://doi.org/10.1242/dev.027805
84 https://doi.org/10.1242/jcs.01601
85 https://doi.org/10.1371/journal.pone.0007841
86 https://doi.org/10.1530/rep-10-0294
87 https://doi.org/10.3892/mmr.2014.1937
88 https://doi.org/10.3892/ol.2015.3943
89 https://doi.org/10.5734/jgm.2012.9.2.78
90 schema:datePublished 2019-03
91 schema:datePublishedReg 2019-03-01
92 schema:description Inadequate migration and invasion of the trophoblast cells during embryo implantation is one of the reasons for pregnancy-related complications such as intrauterine growth restriction and preeclampsia. In the present study, relevance of WNT ligands and integrins associated with hepatocyte growth factor (HGF)-mediated migration of HTR-8/SVneo trophoblastic cells has been investigated. Treatment of HTR-8/SVneo cells with HGF led to a dose-dependent increase in their migration. RT-PCR studies revealed a significant increase in the transcripts of WNT4, WNT11, ITGA2, and ITGAV, which was further confirmed at protein level by Western blotting. HGF treatment also led to increased expression of integrin α2β1 and αVβ5 in HTR-8/SVneo cells. Silencing of WNT4, WNT11, ITGA2, and ITGAV by siRNA led to a significant decrease in HGF-mediated migration of cells. Treatment of cells with HGF led to activation of mitogen-activated protein kinases (MAPK) and protein kinase A (PKA) signaling pathways. Inhibition of MAPK/PKA, by selective inhibitors, led to decrease in the expression of above WNT ligands and integrins. Silencing of WNT4/WNT11 led to concomitant decrease in the expression of ITGA2 and ITGAV and vice versa. HGF treatment also led to significant increase in β-catenin expression, a downstream target of both WNT ligands and integrins. Silencing of β-catenin led to decrease in HGF-mediated migration. β-catenin expression was also down-regulated in WNT4/WNT11/ITGA2/ITGAV silenced cells suggesting a possible cross-communication of WNT ligands and integrins via β-catenin. These studies have established the significance of WNT4/WNT11 as well as ITGA2/ITGAV during HGF-mediated migration of HTR-8/SVneo trophoblastic cells.
93 schema:genre research_article
94 schema:inLanguage en
95 schema:isAccessibleForFree false
96 schema:isPartOf N81ec8c774d9c4928ad120ba02e3cc3a1
97 Nfb93224baa694d8c8c5cfaa05179ad81
98 sg:journal.1016672
99 schema:name HGF promotes HTR-8/SVneo cell migration through activation of MAPK/PKA signaling leading to up-regulation of WNT ligands and integrins that target β-catenin
100 schema:pagination 11-32
101 schema:productId N2e5b48a9f78e416dbf4f6a3df9568f87
102 N4df8d12867964b5e9df97c835b01b3e3
103 N76fcbaa79c4e49e1b4fc7af2c5e24e4e
104 Nb6a051758e5848acab6d048a823e2dbc
105 Nb6dedb127c254934b2d89893a1f0bbb5
106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106284298
107 https://doi.org/10.1007/s11010-018-3428-3
108 schema:sdDatePublished 2019-04-11T10:22
109 schema:sdLicense https://scigraph.springernature.com/explorer/license/
110 schema:sdPublisher N05c1d3a455fb43cdb461a4f84d1b0c2c
111 schema:url https://link.springer.com/10.1007%2Fs11010-018-3428-3
112 sgo:license sg:explorer/license/
113 sgo:sdDataset articles
114 rdf:type schema:ScholarlyArticle
115 N0541b527a1124125b9429216c67ae973 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Hepatocyte Growth Factor
117 rdf:type schema:DefinedTerm
118 N05c1d3a455fb43cdb461a4f84d1b0c2c schema:name Springer Nature - SN SciGraph project
119 rdf:type schema:Organization
120 N1960b65e50a14402bec91515c0ce3758 rdf:first sg:person.010544171076.44
121 rdf:rest N8413502cff5a47dfb0c6fb35c06ca091
122 N2235b40a42084ab0b72a1598c446db5e rdf:first sg:person.01163572543.63
123 rdf:rest Nd1b70ffad73c468cb4723582fdb7787f
124 N2e5b48a9f78e416dbf4f6a3df9568f87 schema:name dimensions_id
125 schema:value pub.1106284298
126 rdf:type schema:PropertyValue
127 N35978a9ec03143119a65edc4d23bff4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name MAP Kinase Signaling System
129 rdf:type schema:DefinedTerm
130 N4df8d12867964b5e9df97c835b01b3e3 schema:name readcube_id
131 schema:value 22f23b430fec2097e9bc9a999a8d9685e3a69be2ed88b50c820c279fc3b7a20f
132 rdf:type schema:PropertyValue
133 N76fcbaa79c4e49e1b4fc7af2c5e24e4e schema:name doi
134 schema:value 10.1007/s11010-018-3428-3
135 rdf:type schema:PropertyValue
136 N77476047699b4169a2d544d2d4ca215b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Cell Movement
138 rdf:type schema:DefinedTerm
139 N7ab0f2a7e1f24a5fae1cbeb849e65432 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Wnt Proteins
141 rdf:type schema:DefinedTerm
142 N81ec8c774d9c4928ad120ba02e3cc3a1 schema:issueNumber 1-2
143 rdf:type schema:PublicationIssue
144 N8413502cff5a47dfb0c6fb35c06ca091 rdf:first sg:person.01257222503.40
145 rdf:rest Nb9d46fecf4724edd8c0efdb736d1f6c4
146 N8d1677266637493299a982693ff62196 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name beta Catenin
148 rdf:type schema:DefinedTerm
149 Na54a1aab4f9844449b3f1a2ca6a0c14c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Wnt4 Protein
151 rdf:type schema:DefinedTerm
152 Nadae40c32fa7498a87d7cd64b441f153 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Cyclic AMP-Dependent Protein Kinases
154 rdf:type schema:DefinedTerm
155 Nb6a051758e5848acab6d048a823e2dbc schema:name nlm_unique_id
156 schema:value 0364456
157 rdf:type schema:PropertyValue
158 Nb6dedb127c254934b2d89893a1f0bbb5 schema:name pubmed_id
159 schema:value 30136190
160 rdf:type schema:PropertyValue
161 Nb9d46fecf4724edd8c0efdb736d1f6c4 rdf:first sg:person.016552034474.23
162 rdf:rest rdf:nil
163 Nc7588ac258e048baa5ea6da4b941883e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Extracellular Signal-Regulated MAP Kinases
165 rdf:type schema:DefinedTerm
166 Nd1b70ffad73c468cb4723582fdb7787f rdf:first sg:person.01222554642.19
167 rdf:rest N1960b65e50a14402bec91515c0ce3758
168 Ndd4478996eb14a95acc3a50b5ff3a92f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Cell Line
170 rdf:type schema:DefinedTerm
171 Ne48685228ecc443f8411322b038d56f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Humans
173 rdf:type schema:DefinedTerm
174 Ne8033e5bb50849819db299384ed1ea8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Trophoblasts
176 rdf:type schema:DefinedTerm
177 Nea22fff93bed4529ad3441558c666afb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Integrins
179 rdf:type schema:DefinedTerm
180 Nfb93224baa694d8c8c5cfaa05179ad81 schema:volumeNumber 453
181 rdf:type schema:PublicationVolume
182 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
183 schema:name Medical and Health Sciences
184 rdf:type schema:DefinedTerm
185 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
186 schema:name Paediatrics and Reproductive Medicine
187 rdf:type schema:DefinedTerm
188 sg:journal.1016672 schema:issn 0300-8177
189 1573-4919
190 schema:name Molecular and Cellular Biochemistry
191 rdf:type schema:Periodical
192 sg:person.010544171076.44 schema:affiliation https://www.grid.ac/institutes/grid.440550.0
193 schema:familyName Babu
194 schema:givenName Gosipatala Sunil
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010544171076.44
196 rdf:type schema:Person
197 sg:person.01163572543.63 schema:affiliation https://www.grid.ac/institutes/grid.440550.0
198 schema:familyName Chaudhary
199 schema:givenName Piyush
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163572543.63
201 rdf:type schema:Person
202 sg:person.01222554642.19 schema:affiliation https://www.grid.ac/institutes/grid.19100.39
203 schema:familyName Malhotra
204 schema:givenName Sudha Saryu
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222554642.19
206 rdf:type schema:Person
207 sg:person.01257222503.40 schema:affiliation https://www.grid.ac/institutes/grid.440550.0
208 schema:familyName Sobti
209 schema:givenName Ranbir Chander
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257222503.40
211 rdf:type schema:Person
212 sg:person.016552034474.23 schema:affiliation https://www.grid.ac/institutes/grid.19100.39
213 schema:familyName Gupta
214 schema:givenName Satish Kumar
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016552034474.23
216 rdf:type schema:Person
217 sg:pub.10.1007/s10585-011-9404-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050003841
218 https://doi.org/10.1007/s10585-011-9404-x
219 rdf:type schema:CreativeWork
220 sg:pub.10.1007/s11060-010-0111-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046104627
221 https://doi.org/10.1007/s11060-010-0111-2
222 rdf:type schema:CreativeWork
223 sg:pub.10.1007/s11373-005-9061-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025235845
224 https://doi.org/10.1007/s11373-005-9061-7
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/373702a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045696614
227 https://doi.org/10.1038/373702a0
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/sj.bjc.6603088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008884427
230 https://doi.org/10.1038/sj.bjc.6603088
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/srep20395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045208198
233 https://doi.org/10.1038/srep20395
234 rdf:type schema:CreativeWork
235 sg:pub.10.1111/1523-1747.ep12472299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041466680
236 https://doi.org/10.1111/1523-1747.ep12472299
237 rdf:type schema:CreativeWork
238 sg:pub.10.1186/1477-7827-10-83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034514120
239 https://doi.org/10.1186/1477-7827-10-83
240 rdf:type schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1074486523 schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1076866321 schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1077464092 schema:CreativeWork
244 https://app.dimensions.ai/details/publication/pub.1077620784 schema:CreativeWork
245 https://app.dimensions.ai/details/publication/pub.1077651513 schema:CreativeWork
246 https://app.dimensions.ai/details/publication/pub.1082400416 schema:CreativeWork
247 https://app.dimensions.ai/details/publication/pub.1082443759 schema:CreativeWork
248 https://app.dimensions.ai/details/publication/pub.1082800914 schema:CreativeWork
249 https://app.dimensions.ai/details/publication/pub.1083186068 schema:CreativeWork
250 https://doi.org/10.1002/jat.3227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038855098
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1002/jcp.21932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029018977
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1006/bbrc.1998.8888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048480914
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1006/bbrc.2000.3252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012048237
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1006/excr.1993.1139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022743133
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1006/excr.1995.1105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050939224
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1006/excr.2002.5616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050410967
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/0002-9378(95)90370-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031807598
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/0092-8674(92)90115-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1007440282
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/0092-8674(93)80043-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1045209738
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/j.bbamcr.2013.09.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033764056
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/j.jri.2009.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004619333
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/j.placenta.2006.11.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019246045
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/j.placenta.2013.06.311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009792818
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/j.placenta.2014.04.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002135428
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/j.ydbio.2012.01.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012684402
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/j.yexcr.2006.09.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023463046
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/s0002-9440(10)65658-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017143390
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/s0143-4004(83)80043-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032822674
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1053/plac.2001.0647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051875656
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1055/s-0028-1108011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057123639
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1073/pnas.90.5.1937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026126708
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1074/jbc.270.21.12851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021334841
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1074/jbc.m010669200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018390952
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1074/jbc.m113.523746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022901887
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1074/jbc.m114.563213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051908524
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1074/jbc.m200187200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008166034
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1074/jbc.m305312200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011758444
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1074/jbc.m402877200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041310896
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1078/0065-1281-00708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019949234
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1083/jcb.142.4.1145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021990625
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1083/jcb.200206011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007283814
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1091/mbc.e08-06-0569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014532764
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1093/hmg/ddv621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012704858
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1093/humupd/2.4.307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033583105
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1093/humupd/dml048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036227173
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1095/biolreprod.109.078634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014779331
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1096/fj.12-217083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009296134
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1128/mcb.00443-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030772685
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1155/2015/201629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000665530
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1158/0008-5472.can-10-0226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019964423
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1158/1541-7786.mcr-09-0238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036941409
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1172/jci115565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030161607
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1172/jci116316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038305490
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1172/jci119388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017050821
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1177/1758834011422556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011306841
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1210/en.2002-220886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064245871
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1210/en.2009-0557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052066616
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1242/dev.00591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042791693
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1242/dev.00821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018378497
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1242/dev.027805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033362510
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1242/jcs.01601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009457939
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1371/journal.pone.0007841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004264883
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1530/rep-10-0294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008302339
357 rdf:type schema:CreativeWork
358 https://doi.org/10.3892/mmr.2014.1937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071521481
359 rdf:type schema:CreativeWork
360 https://doi.org/10.3892/ol.2015.3943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071526766
361 rdf:type schema:CreativeWork
362 https://doi.org/10.5734/jgm.2012.9.2.78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042850920
363 rdf:type schema:CreativeWork
364 https://www.grid.ac/institutes/grid.19100.39 schema:alternateName National Institute of Immunology
365 schema:name Reproductive Cell Biology Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, 110 067, New Delhi, India
366 rdf:type schema:Organization
367 https://www.grid.ac/institutes/grid.440550.0 schema:alternateName Babasaheb Bhimrao Ambedkar University
368 schema:name Babasaheb Bhimrao Ambedkar University, Vidya Vihar, 226 025, Lucknow, India
369 Department of Biotechnology, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, 226 025, Lucknow, India
370 Reproductive Cell Biology Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, 110 067, New Delhi, India
371 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...