Naphtho[1,2-b]furan-4,5-dione inhibits MDA-MB-231 cell migration and invasion by suppressing Src-mediated signaling pathways View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-10-26

AUTHORS

Pei-Chien Tsai, Chiao-Lun Chu, Yaw-Syan Fu, Chih-Hua Tseng, Yeh-long Chen, Long-Sen Chang, Shinne-Ren Lin

ABSTRACT

Naphtho[1,2-b]furan-4,5-dione (NFD), a bioactive component of Avicennia marina, has been demonstrated to display anti-cancer activity. Breast cancer is a highly malignant carcinoma and most deaths of breast cancer are caused by metastasis. In this study, we showed that NFD blocked migration and invasion of MDA-MB-231 breast cancer cells without affecting apoptosis or growth arrest. NFD caused significant block of Src kinase activity in MDA-MB-231 cells. Moreover, NFD treatment was correlated with reduced phosphorylation of FAK at Tyr 576/577, 861 and 925 sites, p130Cas at Tyr 410, and paxillin at Tyr 118. NFD also suppressed the activation of phosphatidylinositol 3-kinase/Akt. Consistent with inhibition of these signaling pathways and invasion, NFD reduced the expression of matrix metalloproteinase-9. Furthermore, Src antagonist PP2 caused a significant decrease in the phosphorylation of FAK, p130Cas, paxillin, and PI3K/Akt. Our findings provide evidences that NFD inhibits Src-mediated signaling pathways involved in controlling breast cancer migration and invasion, suggesting that it has a therapeutic potential in breast cancer treatment. More... »

PAGES

101-111

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11010-013-1875-4

DOI

http://dx.doi.org/10.1007/s11010-013-1875-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033301054

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24162594


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