Involvement of polyamines in iron(III) transport in human intestinal Caco-2 cell lines View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-03-14

AUTHORS

Gérard Lescoat, Lucie Gouffier, Isabelle Cannie, Olive Lowe, Isabelle Morel, Sylvie Lepage, Martine Ropert, Olivier Loréal, Pierre Brissot, François Gaboriau

ABSTRACT

Natural polyamines such as putrescine (Put), spermidine (Spd), and spermine (Spm), which are present in the human diet in large amounts, associated with their active transporter, are assumed to play a role in non-heme iron uptake and iron bioavailability from nutrients. Enterocytes and hepatocytes play pivotal roles in the regulation of body iron homeostasis. In this study, we report the effects of natural polyamines on iron transport in the Caco-2 cell line. In enterocyte-like Caco-2 cells, polyamines did not significantly modulate the transepithelial iron flux across the cell monolayer cultured on permeable membranes. In contrast, Spd, Spm, and to a lesser extent, Put were shown to activate Caco-2 cell iron uptake and to induce an increase in the ferritin level. This iron co-transport in enterocytes, which involved an interaction between iron and polyamine then cell uptake of the polyamine–iron complexes by the polyamine transport system, was more pronounced in proliferating than in differentiated Caco-2 cells. Moreover, it was observed at physiological concentrations of both polyamines and iron. It could thus play a role in the rapid renewal of enterocytes. These data suggest the involvement of polyamines as components of the pool of transferrin-independent iron-chelating vectors. Further investigations are needed to demonstrate their biological relevance in physiological situations. More... »

PAGES

205-215

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11010-013-1611-0

DOI

http://dx.doi.org/10.1007/s11010-013-1611-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025041850

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23494528


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biological Transport", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caco-2 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Membrane Permeability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ferric Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ferritins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polyamines", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 de Rennes 1, 35043, Rennes, France", 
          "id": "http://www.grid.ac/institutes/grid.410368.8", 
          "name": [
            "INSERM, UMR991, H\u00f4pital Pontchaillou, 35033, Rennes, France", 
            "Universit\u00e9 de Rennes 1, 35043, Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lescoat", 
        "givenName": "G\u00e9rard", 
        "id": "sg:person.01070673674.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070673674.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 de Rennes 1, 35043, Rennes, France", 
          "id": "http://www.grid.ac/institutes/grid.410368.8", 
          "name": [
            "INSERM, UMR991, H\u00f4pital Pontchaillou, 35033, Rennes, France", 
            "Universit\u00e9 de Rennes 1, 35043, Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gouffier", 
        "givenName": "Lucie", 
        "id": "sg:person.0675373323.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675373323.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 de Rennes 1, 35043, Rennes, France", 
          "id": "http://www.grid.ac/institutes/grid.410368.8", 
          "name": [
            "INSERM, UMR991, H\u00f4pital Pontchaillou, 35033, Rennes, France", 
            "Universit\u00e9 de Rennes 1, 35043, Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cannie", 
        "givenName": "Isabelle", 
        "id": "sg:person.01053640767.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053640767.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 de Rennes 1, 35043, Rennes, France", 
          "id": "http://www.grid.ac/institutes/grid.410368.8", 
          "name": [
            "INSERM, UMR991, H\u00f4pital Pontchaillou, 35033, Rennes, France", 
            "Universit\u00e9 de Rennes 1, 35043, Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lowe", 
        "givenName": "Olive", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratoire d\u2019urgence et r\u00e9animation, H\u00f4pital Pontchaillou, 35000, Rennes, France", 
          "id": "http://www.grid.ac/institutes/grid.414271.5", 
          "name": [
            "Laboratoire d\u2019urgence et r\u00e9animation, H\u00f4pital Pontchaillou, 35000, Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morel", 
        "givenName": "Isabelle", 
        "id": "sg:person.0610332063.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610332063.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratoire d\u2019urgence et r\u00e9animation, H\u00f4pital Pontchaillou, 35000, Rennes, France", 
          "id": "http://www.grid.ac/institutes/grid.414271.5", 
          "name": [
            "Laboratoire d\u2019urgence et r\u00e9animation, H\u00f4pital Pontchaillou, 35000, Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lepage", 
        "givenName": "Sylvie", 
        "id": "sg:person.0652243503.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652243503.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratoire de Biochimie G\u00e9n\u00e9rale et Enzymologie, H\u00f4pital Pontchaillou, 35000, Rennes, France", 
          "id": "http://www.grid.ac/institutes/grid.414271.5", 
          "name": [
            "Laboratoire de Biochimie G\u00e9n\u00e9rale et Enzymologie, H\u00f4pital Pontchaillou, 35000, Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ropert", 
        "givenName": "Martine", 
        "id": "sg:person.0771434706.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771434706.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 de Rennes 1, 35043, Rennes, France", 
          "id": "http://www.grid.ac/institutes/grid.410368.8", 
          "name": [
            "INSERM, UMR991, H\u00f4pital Pontchaillou, 35033, Rennes, France", 
            "Universit\u00e9 de Rennes 1, 35043, Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lor\u00e9al", 
        "givenName": "Olivier", 
        "id": "sg:person.01067451270.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067451270.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Service des Maladies du Foie, H\u00f4pital Pontchaillou, 35000, Rennes, France", 
          "id": "http://www.grid.ac/institutes/grid.414271.5", 
          "name": [
            "INSERM, UMR991, H\u00f4pital Pontchaillou, 35033, Rennes, France", 
            "Universit\u00e9 de Rennes 1, 35043, Rennes, France", 
            "Service des Maladies du Foie, H\u00f4pital Pontchaillou, 35000, Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brissot", 
        "givenName": "Pierre", 
        "id": "sg:person.0757107606.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757107606.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e9 de Rennes 1, 35043, Rennes, France", 
          "id": "http://www.grid.ac/institutes/grid.410368.8", 
          "name": [
            "INSERM, UMR991, H\u00f4pital Pontchaillou, 35033, Rennes, France", 
            "Universit\u00e9 de Rennes 1, 35043, Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gaboriau", 
        "givenName": "Fran\u00e7ois", 
        "id": "sg:person.01157767143.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157767143.75"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf02634316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026725347", 
          "https://doi.org/10.1007/bf02634316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-94-011-0585-9_2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051637848", 
          "https://doi.org/10.1007/978-94-011-0585-9_2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1012102522787", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027775480", 
          "https://doi.org/10.1023/a:1012102522787"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-03-14", 
    "datePublishedReg": "2013-03-14", 
    "description": "Natural polyamines such as putrescine (Put), spermidine (Spd), and spermine (Spm), which are present in the human diet in large amounts, associated with their active transporter, are assumed to play a role in non-heme iron uptake and iron bioavailability from nutrients. Enterocytes and hepatocytes play pivotal roles in the regulation of body iron homeostasis. In this study, we report the effects of natural polyamines on iron transport in the Caco-2 cell line. In enterocyte-like Caco-2 cells, polyamines did not significantly modulate the transepithelial iron flux across the cell monolayer cultured on permeable membranes. In contrast, Spd, Spm, and to a lesser extent, Put were shown to activate Caco-2 cell iron uptake and to induce an increase in the ferritin level. This iron co-transport in enterocytes, which involved an interaction between iron and polyamine then cell uptake of the polyamine\u2013iron complexes by the polyamine transport system, was more pronounced in proliferating than in differentiated Caco-2 cells. Moreover, it was observed at physiological concentrations of both polyamines and iron. It could thus play a role in the rapid renewal of enterocytes. These data suggest the involvement of polyamines as components of the pool of transferrin-independent iron-chelating vectors. Further investigations are needed to demonstrate their biological relevance in physiological situations.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s11010-013-1611-0", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1016672", 
        "issn": [
          "0300-8177", 
          "1573-4919"
        ], 
        "name": "Molecular and Cellular Biochemistry", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1-2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "378"
      }
    ], 
    "keywords": [
      "involvement of polyamines", 
      "iron uptake", 
      "Caco-2 cell line", 
      "Caco-2 cells", 
      "cell iron uptake", 
      "natural polyamines", 
      "cell lines", 
      "Caco-2 cell iron uptake", 
      "polyamine transport system", 
      "body iron homeostasis", 
      "enterocyte-like Caco-2 cells", 
      "differentiated Caco-2 cells", 
      "active transporters", 
      "human intestinal Caco-2 cell line", 
      "intestinal Caco-2 cell line", 
      "iron transport", 
      "iron homeostasis", 
      "biological relevance", 
      "ferritin levels", 
      "physiological situations", 
      "polyamines", 
      "human diet", 
      "pivotal role", 
      "rapid renewal", 
      "physiological concentrations", 
      "cell monolayers", 
      "transport system", 
      "enterocytes", 
      "iron flux", 
      "further investigation", 
      "iron bioavailability", 
      "cells", 
      "uptake", 
      "cell uptake", 
      "lesser extent", 
      "transporters", 
      "role", 
      "involvement", 
      "homeostasis", 
      "regulation", 
      "nutrients", 
      "lines", 
      "spermidine", 
      "membrane", 
      "putrescine", 
      "transport", 
      "diet", 
      "spermine", 
      "complexes", 
      "pool", 
      "hepatocytes", 
      "bioavailability", 
      "large amount", 
      "interaction", 
      "vector", 
      "iron", 
      "levels", 
      "SPD", 
      "study", 
      "contrast", 
      "increase", 
      "relevance", 
      "effect", 
      "concentration", 
      "renewal", 
      "components", 
      "extent", 
      "data", 
      "monolayers", 
      "permeable membrane", 
      "investigation", 
      "amount", 
      "Put", 
      "SPM", 
      "flux", 
      "system", 
      "situation", 
      "non-heme iron uptake", 
      "transepithelial iron flux", 
      "polyamine\u2013iron complexes", 
      "transferrin-independent iron-chelating vectors", 
      "iron-chelating vectors"
    ], 
    "name": "Involvement of polyamines in iron(III) transport in human intestinal Caco-2 cell lines", 
    "pagination": "205-215", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1025041850"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11010-013-1611-0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23494528"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11010-013-1611-0", 
      "https://app.dimensions.ai/details/publication/pub.1025041850"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_590.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s11010-013-1611-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11010-013-1611-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11010-013-1611-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11010-013-1611-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11010-013-1611-0'


 

This table displays all metadata directly associated to this object as RDF triples.

264 TRIPLES      22 PREDICATES      120 URIs      109 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11010-013-1611-0 schema:about N2a7c1ed975cb41acb615e8af57dec36a
2 N3a5866f6321e4280a21e7a5afe183a27
3 N402cdcfe996b4802b4b14dbc9e4d082d
4 N68ab512fb15e4ba5aa124bbe67a41fab
5 N6996c1ecdd5a443d990697d6913ec75b
6 N79c7ed84d8444339bcd0ee4eb5842aec
7 Nb5b2e0bbd07b43f2b68ee9363beec23f
8 Neb1e10c437514499a3be25357d04dd18
9 Nef60256ba64c4aed80fe80d4bc916f21
10 anzsrc-for:06
11 anzsrc-for:0601
12 schema:author N07df7692eb4c4911998da108fff356e0
13 schema:citation sg:pub.10.1007/978-94-011-0585-9_2
14 sg:pub.10.1007/bf02634316
15 sg:pub.10.1023/a:1012102522787
16 schema:datePublished 2013-03-14
17 schema:datePublishedReg 2013-03-14
18 schema:description Natural polyamines such as putrescine (Put), spermidine (Spd), and spermine (Spm), which are present in the human diet in large amounts, associated with their active transporter, are assumed to play a role in non-heme iron uptake and iron bioavailability from nutrients. Enterocytes and hepatocytes play pivotal roles in the regulation of body iron homeostasis. In this study, we report the effects of natural polyamines on iron transport in the Caco-2 cell line. In enterocyte-like Caco-2 cells, polyamines did not significantly modulate the transepithelial iron flux across the cell monolayer cultured on permeable membranes. In contrast, Spd, Spm, and to a lesser extent, Put were shown to activate Caco-2 cell iron uptake and to induce an increase in the ferritin level. This iron co-transport in enterocytes, which involved an interaction between iron and polyamine then cell uptake of the polyamine–iron complexes by the polyamine transport system, was more pronounced in proliferating than in differentiated Caco-2 cells. Moreover, it was observed at physiological concentrations of both polyamines and iron. It could thus play a role in the rapid renewal of enterocytes. These data suggest the involvement of polyamines as components of the pool of transferrin-independent iron-chelating vectors. Further investigations are needed to demonstrate their biological relevance in physiological situations.
19 schema:genre article
20 schema:inLanguage en
21 schema:isAccessibleForFree false
22 schema:isPartOf N925941f4f573488fae14d2fd02dcf416
23 Nfa7828868912410c807a353f42503b5d
24 sg:journal.1016672
25 schema:keywords Caco-2 cell iron uptake
26 Caco-2 cell line
27 Caco-2 cells
28 Put
29 SPD
30 SPM
31 active transporters
32 amount
33 bioavailability
34 biological relevance
35 body iron homeostasis
36 cell iron uptake
37 cell lines
38 cell monolayers
39 cell uptake
40 cells
41 complexes
42 components
43 concentration
44 contrast
45 data
46 diet
47 differentiated Caco-2 cells
48 effect
49 enterocyte-like Caco-2 cells
50 enterocytes
51 extent
52 ferritin levels
53 flux
54 further investigation
55 hepatocytes
56 homeostasis
57 human diet
58 human intestinal Caco-2 cell line
59 increase
60 interaction
61 intestinal Caco-2 cell line
62 investigation
63 involvement
64 involvement of polyamines
65 iron
66 iron bioavailability
67 iron flux
68 iron homeostasis
69 iron transport
70 iron uptake
71 iron-chelating vectors
72 large amount
73 lesser extent
74 levels
75 lines
76 membrane
77 monolayers
78 natural polyamines
79 non-heme iron uptake
80 nutrients
81 permeable membrane
82 physiological concentrations
83 physiological situations
84 pivotal role
85 polyamine transport system
86 polyamines
87 polyamine–iron complexes
88 pool
89 putrescine
90 rapid renewal
91 regulation
92 relevance
93 renewal
94 role
95 situation
96 spermidine
97 spermine
98 study
99 system
100 transepithelial iron flux
101 transferrin-independent iron-chelating vectors
102 transport
103 transport system
104 transporters
105 uptake
106 vector
107 schema:name Involvement of polyamines in iron(III) transport in human intestinal Caco-2 cell lines
108 schema:pagination 205-215
109 schema:productId N953b48de95d24a8c9ed64ac761820895
110 Na28788beb7054920b496ff67b824249b
111 Nf272b7fba59f4882811f03a87ad5ce4a
112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025041850
113 https://doi.org/10.1007/s11010-013-1611-0
114 schema:sdDatePublished 2022-01-01T18:29
115 schema:sdLicense https://scigraph.springernature.com/explorer/license/
116 schema:sdPublisher Ne0acebf76ab64771a3f74135e938e2cd
117 schema:url https://doi.org/10.1007/s11010-013-1611-0
118 sgo:license sg:explorer/license/
119 sgo:sdDataset articles
120 rdf:type schema:ScholarlyArticle
121 N06b35c6878c1492991260f5467954a31 rdf:first sg:person.01157767143.75
122 rdf:rest rdf:nil
123 N07df7692eb4c4911998da108fff356e0 rdf:first sg:person.01070673674.33
124 rdf:rest N694cbce03bfa476ea140fec386959f7c
125 N2a7c1ed975cb41acb615e8af57dec36a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Cell Proliferation
127 rdf:type schema:DefinedTerm
128 N32cbc1cd9b7240fa9327205e563d2bef rdf:first sg:person.01053640767.94
129 rdf:rest N6e7dc896a8fc4634b666977d185da936
130 N3a5866f6321e4280a21e7a5afe183a27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Polyamines
132 rdf:type schema:DefinedTerm
133 N402cdcfe996b4802b4b14dbc9e4d082d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Caco-2 Cells
135 rdf:type schema:DefinedTerm
136 N68ab512fb15e4ba5aa124bbe67a41fab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Cell Membrane Permeability
138 rdf:type schema:DefinedTerm
139 N694cbce03bfa476ea140fec386959f7c rdf:first sg:person.0675373323.25
140 rdf:rest N32cbc1cd9b7240fa9327205e563d2bef
141 N6996c1ecdd5a443d990697d6913ec75b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Ferritins
143 rdf:type schema:DefinedTerm
144 N69e24059c4e44f679496f59b67a1e75c rdf:first sg:person.0771434706.05
145 rdf:rest N70832038c98c48c8a5c6af813c2174e8
146 N6e7dc896a8fc4634b666977d185da936 rdf:first Nacc0c452b47b49f8b24ed04a84733d27
147 rdf:rest N89ef518fbf714d42be9381252a197fc5
148 N70832038c98c48c8a5c6af813c2174e8 rdf:first sg:person.01067451270.18
149 rdf:rest N742ec3f5d78f4e389e7a547964c4de4c
150 N742ec3f5d78f4e389e7a547964c4de4c rdf:first sg:person.0757107606.24
151 rdf:rest N06b35c6878c1492991260f5467954a31
152 N79c7ed84d8444339bcd0ee4eb5842aec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Cell Differentiation
154 rdf:type schema:DefinedTerm
155 N89ef518fbf714d42be9381252a197fc5 rdf:first sg:person.0610332063.17
156 rdf:rest Ne96f2120d8cd4b86b52faf4d10614899
157 N925941f4f573488fae14d2fd02dcf416 schema:volumeNumber 378
158 rdf:type schema:PublicationVolume
159 N953b48de95d24a8c9ed64ac761820895 schema:name dimensions_id
160 schema:value pub.1025041850
161 rdf:type schema:PropertyValue
162 Na28788beb7054920b496ff67b824249b schema:name doi
163 schema:value 10.1007/s11010-013-1611-0
164 rdf:type schema:PropertyValue
165 Nacc0c452b47b49f8b24ed04a84733d27 schema:affiliation grid-institutes:grid.410368.8
166 schema:familyName Lowe
167 schema:givenName Olive
168 rdf:type schema:Person
169 Nb5b2e0bbd07b43f2b68ee9363beec23f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Ferric Compounds
171 rdf:type schema:DefinedTerm
172 Ne0acebf76ab64771a3f74135e938e2cd schema:name Springer Nature - SN SciGraph project
173 rdf:type schema:Organization
174 Ne96f2120d8cd4b86b52faf4d10614899 rdf:first sg:person.0652243503.51
175 rdf:rest N69e24059c4e44f679496f59b67a1e75c
176 Neb1e10c437514499a3be25357d04dd18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Biological Transport
178 rdf:type schema:DefinedTerm
179 Nef60256ba64c4aed80fe80d4bc916f21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Humans
181 rdf:type schema:DefinedTerm
182 Nf272b7fba59f4882811f03a87ad5ce4a schema:name pubmed_id
183 schema:value 23494528
184 rdf:type schema:PropertyValue
185 Nfa7828868912410c807a353f42503b5d schema:issueNumber 1-2
186 rdf:type schema:PublicationIssue
187 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
188 schema:name Biological Sciences
189 rdf:type schema:DefinedTerm
190 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
191 schema:name Biochemistry and Cell Biology
192 rdf:type schema:DefinedTerm
193 sg:journal.1016672 schema:issn 0300-8177
194 1573-4919
195 schema:name Molecular and Cellular Biochemistry
196 schema:publisher Springer Nature
197 rdf:type schema:Periodical
198 sg:person.01053640767.94 schema:affiliation grid-institutes:grid.410368.8
199 schema:familyName Cannie
200 schema:givenName Isabelle
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053640767.94
202 rdf:type schema:Person
203 sg:person.01067451270.18 schema:affiliation grid-institutes:grid.410368.8
204 schema:familyName Loréal
205 schema:givenName Olivier
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067451270.18
207 rdf:type schema:Person
208 sg:person.01070673674.33 schema:affiliation grid-institutes:grid.410368.8
209 schema:familyName Lescoat
210 schema:givenName Gérard
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070673674.33
212 rdf:type schema:Person
213 sg:person.01157767143.75 schema:affiliation grid-institutes:grid.410368.8
214 schema:familyName Gaboriau
215 schema:givenName François
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157767143.75
217 rdf:type schema:Person
218 sg:person.0610332063.17 schema:affiliation grid-institutes:grid.414271.5
219 schema:familyName Morel
220 schema:givenName Isabelle
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610332063.17
222 rdf:type schema:Person
223 sg:person.0652243503.51 schema:affiliation grid-institutes:grid.414271.5
224 schema:familyName Lepage
225 schema:givenName Sylvie
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652243503.51
227 rdf:type schema:Person
228 sg:person.0675373323.25 schema:affiliation grid-institutes:grid.410368.8
229 schema:familyName Gouffier
230 schema:givenName Lucie
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675373323.25
232 rdf:type schema:Person
233 sg:person.0757107606.24 schema:affiliation grid-institutes:grid.414271.5
234 schema:familyName Brissot
235 schema:givenName Pierre
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757107606.24
237 rdf:type schema:Person
238 sg:person.0771434706.05 schema:affiliation grid-institutes:grid.414271.5
239 schema:familyName Ropert
240 schema:givenName Martine
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771434706.05
242 rdf:type schema:Person
243 sg:pub.10.1007/978-94-011-0585-9_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051637848
244 https://doi.org/10.1007/978-94-011-0585-9_2
245 rdf:type schema:CreativeWork
246 sg:pub.10.1007/bf02634316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026725347
247 https://doi.org/10.1007/bf02634316
248 rdf:type schema:CreativeWork
249 sg:pub.10.1023/a:1012102522787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027775480
250 https://doi.org/10.1023/a:1012102522787
251 rdf:type schema:CreativeWork
252 grid-institutes:grid.410368.8 schema:alternateName Université de Rennes 1, 35043, Rennes, France
253 schema:name INSERM, UMR991, Hôpital Pontchaillou, 35033, Rennes, France
254 Université de Rennes 1, 35043, Rennes, France
255 rdf:type schema:Organization
256 grid-institutes:grid.414271.5 schema:alternateName Laboratoire de Biochimie Générale et Enzymologie, Hôpital Pontchaillou, 35000, Rennes, France
257 Laboratoire d’urgence et réanimation, Hôpital Pontchaillou, 35000, Rennes, France
258 Service des Maladies du Foie, Hôpital Pontchaillou, 35000, Rennes, France
259 schema:name INSERM, UMR991, Hôpital Pontchaillou, 35033, Rennes, France
260 Laboratoire de Biochimie Générale et Enzymologie, Hôpital Pontchaillou, 35000, Rennes, France
261 Laboratoire d’urgence et réanimation, Hôpital Pontchaillou, 35000, Rennes, France
262 Service des Maladies du Foie, Hôpital Pontchaillou, 35000, Rennes, France
263 Université de Rennes 1, 35043, Rennes, France
264 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...