Differential expression of caveolin-1 and caveolin-3: potential marker for cardiac toxicity subsequent to chronic ozone inhalation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-10

AUTHORS

Rajat Sethi, Shubham Manchanda, Rama Surya Prakash Perepu, Ajay Kumar, Carlos Garcia, Richard H. Kennedy, Srinath Palakurthi, David Dostal

ABSTRACT

Earlier studies from our laboratory have shown myocardial dysfunction subsequent to chronic O(3) exposure in rats may be associated with a decrease in antioxidant reserve and increased activity of inflammatory mediators. The present study tested the hypothesis that O(3)-induced cardiac dysfunction in healthy adult rats may be due to changes in caveolin-1 and caveolin-3 levels. Sprague-Dawley rats were exposed 8 h/day for 28 and 56 days to filtered air or 0.8 ppm O(3). In order to assess the chronic effects to O(3), in vivo cardiac function was assessed by measuring LVDP, 24 h after termination of O(3) exposure. Compared to rats exposed to filtered air, LVDP values significantly decreased in all O(3)-exposed animals. This attenuation of cardiac function was associated with increased myocardial TNF-α levels and decreased myocardial activities of superoxidase dismutase. Progressive increases in the expression of myocardial TNF-α in 28 days and 56 days O(3)-exposed animals were followed by decreases in cardiac caveolin-1 levels. On the other hand, differential changes in the expression of caveolin-3 in hearts from 28 and 56 days O(3)-exposed animals were independent of intra-cardiac TNF-α levels. These novel findings suggest the interesting possibility that a balance between caveolin-1 and caveolin-3 may be involved in O(3)-mediated cardiac toxicity. More... »

PAGES

9-15

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11010-012-1363-2

DOI

http://dx.doi.org/10.1007/s11010-012-1363-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026656933

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22752385


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Inhalation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antioxidants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cardiovascular Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caveolin 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caveolin 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Environmental Pollutants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart Ventricles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hemodynamics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxidative Stress", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ozone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Superoxide Dismutase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Necrosis Factor-alpha", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Texas A&M Health Science Center", 
          "id": "https://www.grid.ac/institutes/grid.416970.d", 
          "name": [
            "College of Nursing, Texas A&M University System Health Science Center, Health Professions Education Building, 8447 State Highway 47, Suite 3010, 77807-3260, Bryan, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sethi", 
        "givenName": "Rajat", 
        "id": "sg:person.0733631303.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733631303.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "College of Pharmacy, Texas A&M University System Health Science Center, 78363, Kingsville, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Manchanda", 
        "givenName": "Shubham", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "College of Pharmacy, Texas A&M University System Health Science Center, 78363, Kingsville, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Perepu", 
        "givenName": "Rama Surya Prakash", 
        "id": "sg:person.01274673603.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274673603.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "College of Pharmacy, Texas A&M University System Health Science Center, 78363, Kingsville, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kumar", 
        "givenName": "Ajay", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Texas A&M University \u2013 Kingsville", 
          "id": "https://www.grid.ac/institutes/grid.264760.1", 
          "name": [
            "Department of Biological & Health Sciences, Texas A&M University Kingsville, 78363, Kingsville, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garcia", 
        "givenName": "Carlos", 
        "id": "sg:person.0617402703.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617402703.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Loyola University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.411451.4", 
          "name": [
            "Stritch School of Medicine, Loyola University Medical Center, 60153, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kennedy", 
        "givenName": "Richard H.", 
        "id": "sg:person.0766741324.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766741324.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "College of Pharmacy, Texas A&M University System Health Science Center, 78363, Kingsville, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Palakurthi", 
        "givenName": "Srinath", 
        "id": "sg:person.0672033122.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672033122.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Texas A&M Health Science Center", 
          "id": "https://www.grid.ac/institutes/grid.416967.b", 
          "name": [
            "Division of Molecular Cardiology, Central Texas Veterans Administration Health Care System, Texas A&M University System Health Science Center, 76504, Temple, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dostal", 
        "givenName": "David", 
        "id": "sg:person.0740413216.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740413216.11"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1161/01.cir.0000154546.32135.6e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002405572"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.taap.2006.06.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003638235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10741-008-9104-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003943812", 
          "https://doi.org/10.1007/s10741-008-9104-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10741-008-9104-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003943812", 
          "https://doi.org/10.1007/s10741-008-9104-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yjmcc.2006.08.118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005056084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yjmcc.2006.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006707376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11010-009-0265-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013059986", 
          "https://doi.org/10.1007/s11010-009-0265-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11010-009-0265-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013059986", 
          "https://doi.org/10.1007/s11010-009-0265-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1165/rcmb.2003-0044oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021454569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/rccm.200611-1627oc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022758405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs20070444", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024254342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs20070444", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024254342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.97.11.1095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026954853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.100.11.1189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030911522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/japplphysiol.00921.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031839625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/13543784.14.2.163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034900847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.101.11.1267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035362117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.99.25.3224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042261690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11010-011-1073-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043344213", 
          "https://doi.org/10.1007/s11010-011-1073-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.01354.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045003091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1540-8191.2007.00419.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045171319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00011-008-7237-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047683491", 
          "https://doi.org/10.1007/s00011-008-7237-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.97.14.1375", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050108856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.93.4.704", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063336984"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.81.2.187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063341114"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-10", 
    "datePublishedReg": "2012-10-01", 
    "description": "Earlier studies from our laboratory have shown myocardial dysfunction subsequent to chronic O(3) exposure in rats may be associated with a decrease in antioxidant reserve and increased activity of inflammatory mediators. The present study tested the hypothesis that O(3)-induced cardiac dysfunction in healthy adult rats may be due to changes in caveolin-1 and caveolin-3 levels. Sprague-Dawley rats were exposed 8 h/day for 28 and 56 days to filtered air or 0.8 ppm O(3). In order to assess the chronic effects to O(3), in vivo cardiac function was assessed by measuring LVDP, 24 h after termination of O(3) exposure. Compared to rats exposed to filtered air, LVDP values significantly decreased in all O(3)-exposed animals. This attenuation of cardiac function was associated with increased myocardial TNF-\u03b1 levels and decreased myocardial activities of superoxidase dismutase. Progressive increases in the expression of myocardial TNF-\u03b1 in 28 days and 56 days O(3)-exposed animals were followed by decreases in cardiac caveolin-1 levels. On the other hand, differential changes in the expression of caveolin-3 in hearts from 28 and 56 days O(3)-exposed animals were independent of intra-cardiac TNF-\u03b1 levels. These novel findings suggest the interesting possibility that a balance between caveolin-1 and caveolin-3 may be involved in O(3)-mediated cardiac toxicity.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11010-012-1363-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1016672", 
        "issn": [
          "0300-8177", 
          "1573-4919"
        ], 
        "name": "Molecular and Cellular Biochemistry", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1-2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "369"
      }
    ], 
    "name": "Differential expression of caveolin-1 and caveolin-3: potential marker for cardiac toxicity subsequent to chronic ozone inhalation", 
    "pagination": "9-15", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7efdab40d50ba473c38baa466ecadf855e8f31b344a8dec25dfdfed023e748ac"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22752385"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0364456"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11010-012-1363-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1026656933"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11010-012-1363-2", 
      "https://app.dimensions.ai/details/publication/pub.1026656933"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T02:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000513.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11010-012-1363-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11010-012-1363-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11010-012-1363-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11010-012-1363-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11010-012-1363-2'


 

This table displays all metadata directly associated to this object as RDF triples.

275 TRIPLES      21 PREDICATES      69 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11010-012-1363-2 schema:about N017f956175c842c6a42daa0f881951ce
2 N22419dc8d41f4662a7fbe2f828b5d87b
3 N38222f9deea4408ebd4d30e5c1bf5ab0
4 N3cee71b451a842e9af0787cac9a08a91
5 N44750c22dc194a6fa12bc7ff9341bbe4
6 N5243fab30f9946e9b1c51f0ad29e18d6
7 N5c9c97590c624cc9ad4207fd7b911d8f
8 N6d7c0fd831694f8f8847d42d3e90ccf7
9 N714fb900d5f7454da4b5aaa07b19691c
10 N77e960cd6916450fa5f4d0c909f8a36c
11 N7d35a9d5669e406fa11d25ebecda956a
12 N96a1dfb1a1cd4c9599edebe75f334231
13 Nb245a134f45744b4941563cfe5e4ee0d
14 Nb9a12650b07f42fbba720cb5ef4e4f94
15 Nbc0984bb1e04495a9ca274e43669899a
16 Nc1418c9a01824975a3b0725e837ccf65
17 Nd5f6cb0159444372b1845ac3f25b4436
18 Nd96b15b4948a4650a493347620ae6c4f
19 anzsrc-for:11
20 anzsrc-for:1102
21 schema:author N4360c553134d4d3cbe4820b53c891f41
22 schema:citation sg:pub.10.1007/s00011-008-7237-0
23 sg:pub.10.1007/s10741-008-9104-z
24 sg:pub.10.1007/s11010-009-0265-4
25 sg:pub.10.1007/s11010-011-1073-1
26 https://doi.org/10.1016/j.taap.2006.06.009
27 https://doi.org/10.1016/j.yjmcc.2006.08.005
28 https://doi.org/10.1016/j.yjmcc.2006.08.118
29 https://doi.org/10.1042/cs20070444
30 https://doi.org/10.1111/j.1540-8191.2007.00419.x
31 https://doi.org/10.1152/ajpheart.01354.2005
32 https://doi.org/10.1152/japplphysiol.00921.2006
33 https://doi.org/10.1161/01.cir.0000154546.32135.6e
34 https://doi.org/10.1161/01.cir.100.11.1189
35 https://doi.org/10.1161/01.cir.101.11.1267
36 https://doi.org/10.1161/01.cir.93.4.704
37 https://doi.org/10.1161/01.cir.97.11.1095
38 https://doi.org/10.1161/01.cir.97.14.1375
39 https://doi.org/10.1161/01.cir.99.25.3224
40 https://doi.org/10.1161/01.res.81.2.187
41 https://doi.org/10.1164/rccm.200611-1627oc
42 https://doi.org/10.1165/rcmb.2003-0044oc
43 https://doi.org/10.1517/13543784.14.2.163
44 schema:datePublished 2012-10
45 schema:datePublishedReg 2012-10-01
46 schema:description Earlier studies from our laboratory have shown myocardial dysfunction subsequent to chronic O(3) exposure in rats may be associated with a decrease in antioxidant reserve and increased activity of inflammatory mediators. The present study tested the hypothesis that O(3)-induced cardiac dysfunction in healthy adult rats may be due to changes in caveolin-1 and caveolin-3 levels. Sprague-Dawley rats were exposed 8 h/day for 28 and 56 days to filtered air or 0.8 ppm O(3). In order to assess the chronic effects to O(3), in vivo cardiac function was assessed by measuring LVDP, 24 h after termination of O(3) exposure. Compared to rats exposed to filtered air, LVDP values significantly decreased in all O(3)-exposed animals. This attenuation of cardiac function was associated with increased myocardial TNF-α levels and decreased myocardial activities of superoxidase dismutase. Progressive increases in the expression of myocardial TNF-α in 28 days and 56 days O(3)-exposed animals were followed by decreases in cardiac caveolin-1 levels. On the other hand, differential changes in the expression of caveolin-3 in hearts from 28 and 56 days O(3)-exposed animals were independent of intra-cardiac TNF-α levels. These novel findings suggest the interesting possibility that a balance between caveolin-1 and caveolin-3 may be involved in O(3)-mediated cardiac toxicity.
47 schema:genre research_article
48 schema:inLanguage en
49 schema:isAccessibleForFree false
50 schema:isPartOf N45cff4d5c7ab49cdb2013eeddcee892b
51 Nc91b4ff4c0e24556841ab94919da792d
52 sg:journal.1016672
53 schema:name Differential expression of caveolin-1 and caveolin-3: potential marker for cardiac toxicity subsequent to chronic ozone inhalation
54 schema:pagination 9-15
55 schema:productId N1e4e391da5e04f7aa060e1cdb1370e40
56 N1fee04b8b43f4a46aa30f61ce3550851
57 Nb9d075bcacdb4320a481c846f4043732
58 Nd456088f1ab848d9b89a307eb953d8ed
59 Ndc8dff6e5732457e915d5500dd7c8104
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026656933
61 https://doi.org/10.1007/s11010-012-1363-2
62 schema:sdDatePublished 2019-04-11T02:01
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher N37246e1ede1c433890811361b992d6e3
65 schema:url http://link.springer.com/10.1007%2Fs11010-012-1363-2
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N0047c3fe968c4f8daa117aaf1f4b4d52 rdf:first sg:person.0766741324.47
70 rdf:rest N750a32993ffa43f2b13a2906c3c0980e
71 N017f956175c842c6a42daa0f881951ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Ozone
73 rdf:type schema:DefinedTerm
74 N1e4e391da5e04f7aa060e1cdb1370e40 schema:name doi
75 schema:value 10.1007/s11010-012-1363-2
76 rdf:type schema:PropertyValue
77 N1fee04b8b43f4a46aa30f61ce3550851 schema:name readcube_id
78 schema:value 7efdab40d50ba473c38baa466ecadf855e8f31b344a8dec25dfdfed023e748ac
79 rdf:type schema:PropertyValue
80 N22419dc8d41f4662a7fbe2f828b5d87b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Superoxide Dismutase
82 rdf:type schema:DefinedTerm
83 N33308d08bbaa401c837f624c6e55db40 schema:name College of Pharmacy, Texas A&M University System Health Science Center, 78363, Kingsville, TX, USA
84 rdf:type schema:Organization
85 N337e7efdf1ec4555b71eec2de34d0eff schema:affiliation Ne20b4e27a8b54a50add9d1593e95cb9b
86 schema:familyName Kumar
87 schema:givenName Ajay
88 rdf:type schema:Person
89 N37246e1ede1c433890811361b992d6e3 schema:name Springer Nature - SN SciGraph project
90 rdf:type schema:Organization
91 N38222f9deea4408ebd4d30e5c1bf5ab0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Animals
93 rdf:type schema:DefinedTerm
94 N3cee71b451a842e9af0787cac9a08a91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Caveolin 1
96 rdf:type schema:DefinedTerm
97 N3f7c4ee81e34403b9b39e1eab01b28cd rdf:first sg:person.01274673603.88
98 rdf:rest N9e40a7163355445d98a108e24ece3e1e
99 N408fafbe28654241b2c4926c0836d92f schema:name College of Pharmacy, Texas A&M University System Health Science Center, 78363, Kingsville, TX, USA
100 rdf:type schema:Organization
101 N4360c553134d4d3cbe4820b53c891f41 rdf:first sg:person.0733631303.07
102 rdf:rest N670f65560cdf4236af1449703bcd2e1a
103 N44750c22dc194a6fa12bc7ff9341bbe4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Rats
105 rdf:type schema:DefinedTerm
106 N45cff4d5c7ab49cdb2013eeddcee892b schema:issueNumber 1-2
107 rdf:type schema:PublicationIssue
108 N4a552af6b47d4650ac2ae9a0ac2d234b rdf:first sg:person.0617402703.39
109 rdf:rest N0047c3fe968c4f8daa117aaf1f4b4d52
110 N5243fab30f9946e9b1c51f0ad29e18d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Tumor Necrosis Factor-alpha
112 rdf:type schema:DefinedTerm
113 N55d6e450c3d14c03aef06d3f9552b470 rdf:first sg:person.0740413216.11
114 rdf:rest rdf:nil
115 N5c9c97590c624cc9ad4207fd7b911d8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Heart Ventricles
117 rdf:type schema:DefinedTerm
118 N670f65560cdf4236af1449703bcd2e1a rdf:first N7d146b2194b44903aa7a589f7370cc20
119 rdf:rest N3f7c4ee81e34403b9b39e1eab01b28cd
120 N6d7c0fd831694f8f8847d42d3e90ccf7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Heart
122 rdf:type schema:DefinedTerm
123 N714fb900d5f7454da4b5aaa07b19691c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Caveolin 3
125 rdf:type schema:DefinedTerm
126 N750a32993ffa43f2b13a2906c3c0980e rdf:first sg:person.0672033122.78
127 rdf:rest N55d6e450c3d14c03aef06d3f9552b470
128 N77e960cd6916450fa5f4d0c909f8a36c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Gene Expression
130 rdf:type schema:DefinedTerm
131 N7d146b2194b44903aa7a589f7370cc20 schema:affiliation N408fafbe28654241b2c4926c0836d92f
132 schema:familyName Manchanda
133 schema:givenName Shubham
134 rdf:type schema:Person
135 N7d35a9d5669e406fa11d25ebecda956a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Oxidative Stress
137 rdf:type schema:DefinedTerm
138 N96a1dfb1a1cd4c9599edebe75f334231 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Cardiovascular Diseases
140 rdf:type schema:DefinedTerm
141 N9e40a7163355445d98a108e24ece3e1e rdf:first N337e7efdf1ec4555b71eec2de34d0eff
142 rdf:rest N4a552af6b47d4650ac2ae9a0ac2d234b
143 Nb245a134f45744b4941563cfe5e4ee0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Administration, Inhalation
145 rdf:type schema:DefinedTerm
146 Nb9a12650b07f42fbba720cb5ef4e4f94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Environmental Pollutants
148 rdf:type schema:DefinedTerm
149 Nb9d075bcacdb4320a481c846f4043732 schema:name pubmed_id
150 schema:value 22752385
151 rdf:type schema:PropertyValue
152 Nbc0984bb1e04495a9ca274e43669899a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Hemodynamics
154 rdf:type schema:DefinedTerm
155 Nc1418c9a01824975a3b0725e837ccf65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Rats, Sprague-Dawley
157 rdf:type schema:DefinedTerm
158 Nc91b4ff4c0e24556841ab94919da792d schema:volumeNumber 369
159 rdf:type schema:PublicationVolume
160 Nd456088f1ab848d9b89a307eb953d8ed schema:name dimensions_id
161 schema:value pub.1026656933
162 rdf:type schema:PropertyValue
163 Nd5f6cb0159444372b1845ac3f25b4436 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Male
165 rdf:type schema:DefinedTerm
166 Nd96b15b4948a4650a493347620ae6c4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Antioxidants
168 rdf:type schema:DefinedTerm
169 Nda0b68083f0f45488a9a581b2e90de8c schema:name College of Pharmacy, Texas A&M University System Health Science Center, 78363, Kingsville, TX, USA
170 rdf:type schema:Organization
171 Ndc8dff6e5732457e915d5500dd7c8104 schema:name nlm_unique_id
172 schema:value 0364456
173 rdf:type schema:PropertyValue
174 Ne20b4e27a8b54a50add9d1593e95cb9b schema:name College of Pharmacy, Texas A&M University System Health Science Center, 78363, Kingsville, TX, USA
175 rdf:type schema:Organization
176 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
177 schema:name Medical and Health Sciences
178 rdf:type schema:DefinedTerm
179 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
180 schema:name Cardiorespiratory Medicine and Haematology
181 rdf:type schema:DefinedTerm
182 sg:journal.1016672 schema:issn 0300-8177
183 1573-4919
184 schema:name Molecular and Cellular Biochemistry
185 rdf:type schema:Periodical
186 sg:person.01274673603.88 schema:affiliation N33308d08bbaa401c837f624c6e55db40
187 schema:familyName Perepu
188 schema:givenName Rama Surya Prakash
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274673603.88
190 rdf:type schema:Person
191 sg:person.0617402703.39 schema:affiliation https://www.grid.ac/institutes/grid.264760.1
192 schema:familyName Garcia
193 schema:givenName Carlos
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617402703.39
195 rdf:type schema:Person
196 sg:person.0672033122.78 schema:affiliation Nda0b68083f0f45488a9a581b2e90de8c
197 schema:familyName Palakurthi
198 schema:givenName Srinath
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672033122.78
200 rdf:type schema:Person
201 sg:person.0733631303.07 schema:affiliation https://www.grid.ac/institutes/grid.416970.d
202 schema:familyName Sethi
203 schema:givenName Rajat
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733631303.07
205 rdf:type schema:Person
206 sg:person.0740413216.11 schema:affiliation https://www.grid.ac/institutes/grid.416967.b
207 schema:familyName Dostal
208 schema:givenName David
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740413216.11
210 rdf:type schema:Person
211 sg:person.0766741324.47 schema:affiliation https://www.grid.ac/institutes/grid.411451.4
212 schema:familyName Kennedy
213 schema:givenName Richard H.
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766741324.47
215 rdf:type schema:Person
216 sg:pub.10.1007/s00011-008-7237-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047683491
217 https://doi.org/10.1007/s00011-008-7237-0
218 rdf:type schema:CreativeWork
219 sg:pub.10.1007/s10741-008-9104-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1003943812
220 https://doi.org/10.1007/s10741-008-9104-z
221 rdf:type schema:CreativeWork
222 sg:pub.10.1007/s11010-009-0265-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013059986
223 https://doi.org/10.1007/s11010-009-0265-4
224 rdf:type schema:CreativeWork
225 sg:pub.10.1007/s11010-011-1073-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043344213
226 https://doi.org/10.1007/s11010-011-1073-1
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.taap.2006.06.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003638235
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.yjmcc.2006.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006707376
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/j.yjmcc.2006.08.118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005056084
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1042/cs20070444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024254342
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1111/j.1540-8191.2007.00419.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045171319
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1152/ajpheart.01354.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045003091
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1152/japplphysiol.00921.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031839625
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1161/01.cir.0000154546.32135.6e schema:sameAs https://app.dimensions.ai/details/publication/pub.1002405572
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1161/01.cir.100.11.1189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030911522
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1161/01.cir.101.11.1267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035362117
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1161/01.cir.93.4.704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063336984
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1161/01.cir.97.11.1095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026954853
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1161/01.cir.97.14.1375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050108856
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1161/01.cir.99.25.3224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042261690
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1161/01.res.81.2.187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063341114
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1164/rccm.200611-1627oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1022758405
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1165/rcmb.2003-0044oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1021454569
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1517/13543784.14.2.163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034900847
263 rdf:type schema:CreativeWork
264 https://www.grid.ac/institutes/grid.264760.1 schema:alternateName Texas A&M University – Kingsville
265 schema:name Department of Biological & Health Sciences, Texas A&M University Kingsville, 78363, Kingsville, TX, USA
266 rdf:type schema:Organization
267 https://www.grid.ac/institutes/grid.411451.4 schema:alternateName Loyola University Medical Center
268 schema:name Stritch School of Medicine, Loyola University Medical Center, 60153, Chicago, IL, USA
269 rdf:type schema:Organization
270 https://www.grid.ac/institutes/grid.416967.b schema:alternateName Texas A&M Health Science Center
271 schema:name Division of Molecular Cardiology, Central Texas Veterans Administration Health Care System, Texas A&M University System Health Science Center, 76504, Temple, TX, USA
272 rdf:type schema:Organization
273 https://www.grid.ac/institutes/grid.416970.d schema:alternateName Texas A&M Health Science Center
274 schema:name College of Nursing, Texas A&M University System Health Science Center, Health Professions Education Building, 8447 State Highway 47, Suite 3010, 77807-3260, Bryan, TX, USA
275 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...