Proteomic profiling of human bone marrow mesenchymal stem cells under shear stress View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-08

AUTHORS

Wei Yi, Yang Sun, Xufeng Wei, Chunhu Gu, Xiaochao Dong, Xiaojun Kang, Shuzhong Guo, Kefeng Dou

ABSTRACT

Mesenchymal stem cells (MSCs) are promising seed cells for tissue engineering of blood vessels. As seed cells, MSCs must endure blood fluid shear stress after transplantation. It has been shown that fluid shear stress can regulate the proliferation and differentiation of MSCs. However, the effects of fluid shear stress on MSCs including the types of proteins modulated are still not well understood. In this study, we exposed human mesenchymal stem cells (HMSCs) to 3 dyn/cm(2) shear stress for 6 h and compared them to a control group using proteomic analysis. Thirteen specific proteins were affected by shear stress, 10 of which were up-regulated. Shear stress especially induced sustained increases in the expression of Annexin A2 and GAPDH, which have been specifically shown to affect HMSCs function. We present here the first comparative proteome analysis of effect of shear stress on HMSCs. More... »

PAGES

9-16

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11010-010-0432-7

DOI

http://dx.doi.org/10.1007/s11010-010-0432-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014147201

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20407807


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