ST2 gene expression is proliferation-dependent and its ligand, IL-33, induces inflammatory reaction in endothelial cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-02

AUTHORS

Shinsuke Aoki, Morisada Hayakawa, Hiromi Ozaki, Naoki Takezako, Hiroto Obata, Nobuhiro Ibaraki, Tadahiko Tsuru, Shin-ichi Tominaga, Ken Yanagisawa

ABSTRACT

ST2 gene products that are members of IL-1 receptor family are expressed in various cells such as growth-stimulated fibroblasts and Th2 helper T-cells, and recently, IL-33, which belongs to IL-1 family, was identified as the ligand for ST2L, the receptor type product of the ST2 gene. Subsequently, IL-33 and ST2L have been reported to be involved in Th2 immunity and inflammation, however, their functions on non-immunological cells are still obscure. Among non-immunological adhesive cells, vascular endothelial cells were reported to express both ST2 gene products and IL-33, therefore, we investigated the expression manner of the ST2 gene in vascular endothelial cells and the effect of IL-33 on endothelial cells. ST2 gene was expressed in each of the vascular endothelial cell types tested, and the expression was growth-dependent and down-regulated when the cells were differentiated to form vascular structures on the extracellular membrane matrix. IL-33 scarcely affected the growth and tube formation of the endothelial cells, but induced IL-6 and IL-8 secretion from endothelial cells with the rapid activation of extracellular signal-regulated kinase (ERK) 1/2, so IL-33 is supposed to involve in inflammatory reaction of vascular endothelial cells through its receptor, ST2L. More... »

PAGES

75-81

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11010-009-0244-9

DOI

http://dx.doi.org/10.1007/s11010-009-0244-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003278466

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19756962


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