Skeletal muscle hexokinase: regulation in mammalian hibernation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-12

AUTHORS

Khalil Abnous, Kenneth B. Storey

ABSTRACT

Skeletal muscle hexokinase (HK) from Richardson's ground squirrels was analyzed to determine how the enzyme is regulated during hibernation, a state of cold torpor. The HK II isozyme dominated in muscle and ~15% of total HK was bound to the insoluble fraction. HK maximum activity was 33% lower in hibernator muscle and the enzyme showed a significantly higher K ( m ) ATP (by 80%) and a lower K ( i ) for glucose-6-P (by 40%) than euthermic HK (assayed at 22 degrees C). However, 5 degrees C assay significantly reduced K ( m ) glucose of hibernator HK. Stimulation of AMP-dependent protein kinase (AMPK) in hibernator extracts elevated the HK activity and reduced K ( m ) ATP, but did not affect euthermic HK. Stimulation of protein phosphatases significantly lowered the HK activity in both situations. AMPK-dependent phosphorylation was confirmed by immunopreciptiation of (32)P-labeled HK. DEAE-Sephadex ion exchange chromatography revealed two peaks of HK in hibernator muscle extracts (low and high phosphate forms), whereas only a single peak of phospho-HK was present in euthermic muscle. We conclude that differential control of muscle HK in euthermic versus hibernating states is derived from two main regulatory influences, reversible protein phosphorylation and temperature effects on kinetic properties. More... »

PAGES

41-50

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11010-008-9875-5

DOI

http://dx.doi.org/10.1007/s11010-008-9875-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050908264

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18642117


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "AMP-Activated Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenosine Triphosphate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose-6-Phosphate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hexokinase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hibernation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle, Skeletal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphoprotein Phosphatases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rodentia", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Carleton University", 
          "id": "https://www.grid.ac/institutes/grid.34428.39", 
          "name": [
            "Institute of Biochemistry and Department of Chemistry, Carleton University, 1125 Colonel By Drive, K1S 5B6, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abnous", 
        "givenName": "Khalil", 
        "id": "sg:person.01106117210.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106117210.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Carleton University", 
          "id": "https://www.grid.ac/institutes/grid.34428.39", 
          "name": [
            "Institute of Biochemistry and Department of Chemistry, Carleton University, 1125 Colonel By Drive, K1S 5B6, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Storey", 
        "givenName": "Kenneth B.", 
        "id": "sg:person.0601365426.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601365426.50"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1139/o00-086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001778113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.00278.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003080469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s1464793103006195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007197914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0250103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019752700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0250103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019752700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4419-8997-0_3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019997045", 
          "https://doi.org/10.1007/978-1-4419-8997-0_3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021261365", 
          "https://doi.org/10.1038/nmeth740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021261365", 
          "https://doi.org/10.1038/nmeth740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.abb.2007.07.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021738471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.50.6.1253", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022984823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-1925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024115884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-291x(64)90038-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024193197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-9861(85)90633-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027325843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.physiol.66.032102.115105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028138749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/abbi.1999.1686", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030496190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s003600050172", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031680174", 
          "https://doi.org/10.1007/s003600050172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jeb.00241", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036565895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1998.9960", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042450783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0300-9629(97)00238-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046237713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.54.4.1218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048427012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bfb0049776", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051254770", 
          "https://doi.org/10.1007/bfb0049776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bfb0049776", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051254770", 
          "https://doi.org/10.1007/bfb0049776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jappl.1999.87.5.1990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074550496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076636206", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080203845", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082545110", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-12", 
    "datePublishedReg": "2008-12-01", 
    "description": "Skeletal muscle hexokinase (HK) from Richardson's ground squirrels was analyzed to determine how the enzyme is regulated during hibernation, a state of cold torpor. The HK II isozyme dominated in muscle and ~15% of total HK was bound to the insoluble fraction. HK maximum activity was 33% lower in hibernator muscle and the enzyme showed a significantly higher K ( m ) ATP (by 80%) and a lower K ( i ) for glucose-6-P (by 40%) than euthermic HK (assayed at 22 degrees C). However, 5 degrees C assay significantly reduced K ( m ) glucose of hibernator HK. Stimulation of AMP-dependent protein kinase (AMPK) in hibernator extracts elevated the HK activity and reduced K ( m ) ATP, but did not affect euthermic HK. Stimulation of protein phosphatases significantly lowered the HK activity in both situations. AMPK-dependent phosphorylation was confirmed by immunopreciptiation of (32)P-labeled HK. DEAE-Sephadex ion exchange chromatography revealed two peaks of HK in hibernator muscle extracts (low and high phosphate forms), whereas only a single peak of phospho-HK was present in euthermic muscle. We conclude that differential control of muscle HK in euthermic versus hibernating states is derived from two main regulatory influences, reversible protein phosphorylation and temperature effects on kinetic properties.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s11010-008-9875-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1016672", 
        "issn": [
          "0300-8177", 
          "1573-4919"
        ], 
        "name": "Molecular and Cellular Biochemistry", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1-2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "319"
      }
    ], 
    "name": "Skeletal muscle hexokinase: regulation in mammalian hibernation", 
    "pagination": "41-50", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f2823acb486bf1d54461251bcaf3959b8eb94d0162959c40063a28f4e90efafa"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18642117"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0364456"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11010-008-9875-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1050908264"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11010-008-9875-5", 
      "https://app.dimensions.ai/details/publication/pub.1050908264"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:38", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000516.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs11010-008-9875-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11010-008-9875-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11010-008-9875-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11010-008-9875-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11010-008-9875-5'


 

This table displays all metadata directly associated to this object as RDF triples.

186 TRIPLES      21 PREDICATES      62 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11010-008-9875-5 schema:about N06c19fbf33a342ae8bb1ee41a6fa6414
2 N1dab9d637992462bad2188ef6fcc3584
3 N374823a3e70b4a588b19a411bbec078b
4 N4ae5de7e5d4e4927a1f732a763bd9f94
5 N503a646951f54825aac506b0bd9106e7
6 N5aacba2a02214f77a92ba19318ada547
7 N667c51c2c11547e99d376165084ee460
8 N7255c2e4e1fe4dba9e617c47813c8ea4
9 Nab71312c6db7410783be3ade5a60d9fc
10 Nc2d82b1cb5af4721851eaf92deee488e
11 anzsrc-for:06
12 anzsrc-for:0601
13 schema:author N264651f07e04421aa510cbe805574a4a
14 schema:citation sg:pub.10.1007/978-1-4419-8997-0_3
15 sg:pub.10.1007/bfb0049776
16 sg:pub.10.1007/s003600050172
17 sg:pub.10.1038/nmeth740
18 https://app.dimensions.ai/details/publication/pub.1076636206
19 https://app.dimensions.ai/details/publication/pub.1080203845
20 https://app.dimensions.ai/details/publication/pub.1082545110
21 https://doi.org/10.1006/abbi.1999.1686
22 https://doi.org/10.1006/bbrc.1998.9960
23 https://doi.org/10.1016/0003-9861(85)90633-2
24 https://doi.org/10.1016/0006-291x(64)90038-5
25 https://doi.org/10.1016/j.abb.2007.07.025
26 https://doi.org/10.1016/s0300-9629(97)00238-7
27 https://doi.org/10.1017/s1464793103006195
28 https://doi.org/10.1042/bst0250103
29 https://doi.org/10.1073/pnas.54.4.1218
30 https://doi.org/10.1139/o00-086
31 https://doi.org/10.1146/annurev.physiol.66.032102.115105
32 https://doi.org/10.1152/ajpendo.00278.2002
33 https://doi.org/10.1152/jappl.1999.87.5.1990
34 https://doi.org/10.1158/0008-5472.can-05-1925
35 https://doi.org/10.1242/jeb.00241
36 https://doi.org/10.2337/diabetes.50.6.1253
37 schema:datePublished 2008-12
38 schema:datePublishedReg 2008-12-01
39 schema:description Skeletal muscle hexokinase (HK) from Richardson's ground squirrels was analyzed to determine how the enzyme is regulated during hibernation, a state of cold torpor. The HK II isozyme dominated in muscle and ~15% of total HK was bound to the insoluble fraction. HK maximum activity was 33% lower in hibernator muscle and the enzyme showed a significantly higher K ( m ) ATP (by 80%) and a lower K ( i ) for glucose-6-P (by 40%) than euthermic HK (assayed at 22 degrees C). However, 5 degrees C assay significantly reduced K ( m ) glucose of hibernator HK. Stimulation of AMP-dependent protein kinase (AMPK) in hibernator extracts elevated the HK activity and reduced K ( m ) ATP, but did not affect euthermic HK. Stimulation of protein phosphatases significantly lowered the HK activity in both situations. AMPK-dependent phosphorylation was confirmed by immunopreciptiation of (32)P-labeled HK. DEAE-Sephadex ion exchange chromatography revealed two peaks of HK in hibernator muscle extracts (low and high phosphate forms), whereas only a single peak of phospho-HK was present in euthermic muscle. We conclude that differential control of muscle HK in euthermic versus hibernating states is derived from two main regulatory influences, reversible protein phosphorylation and temperature effects on kinetic properties.
40 schema:genre research_article
41 schema:inLanguage en
42 schema:isAccessibleForFree false
43 schema:isPartOf N295dd9f4d00e494f87752362560f06b9
44 Nade38e4c37b343c1b4ba958051b2a639
45 sg:journal.1016672
46 schema:name Skeletal muscle hexokinase: regulation in mammalian hibernation
47 schema:pagination 41-50
48 schema:productId N0a301230ffab46d0ab47c54e9b9a080e
49 N5e2c899feda5488d9624c9b5f7df812d
50 N73562cba874947399470e45e3d63e314
51 N93e63989dc244088843a9888df9f35a1
52 N9a8c5d37a427459f8ac3b8cc80df92c0
53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050908264
54 https://doi.org/10.1007/s11010-008-9875-5
55 schema:sdDatePublished 2019-04-10T21:38
56 schema:sdLicense https://scigraph.springernature.com/explorer/license/
57 schema:sdPublisher Nf304768b7cb541e2999745f5d74e1c18
58 schema:url http://link.springer.com/10.1007%2Fs11010-008-9875-5
59 sgo:license sg:explorer/license/
60 sgo:sdDataset articles
61 rdf:type schema:ScholarlyArticle
62 N06c19fbf33a342ae8bb1ee41a6fa6414 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Adenosine Triphosphate
64 rdf:type schema:DefinedTerm
65 N0a301230ffab46d0ab47c54e9b9a080e schema:name dimensions_id
66 schema:value pub.1050908264
67 rdf:type schema:PropertyValue
68 N1dab9d637992462bad2188ef6fcc3584 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Glucose-6-Phosphate
70 rdf:type schema:DefinedTerm
71 N264651f07e04421aa510cbe805574a4a rdf:first sg:person.01106117210.43
72 rdf:rest Nbeb6474019374e4bbacea4466fdd1e88
73 N295dd9f4d00e494f87752362560f06b9 schema:volumeNumber 319
74 rdf:type schema:PublicationVolume
75 N374823a3e70b4a588b19a411bbec078b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Animals
77 rdf:type schema:DefinedTerm
78 N4ae5de7e5d4e4927a1f732a763bd9f94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Rodentia
80 rdf:type schema:DefinedTerm
81 N503a646951f54825aac506b0bd9106e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name AMP-Activated Protein Kinases
83 rdf:type schema:DefinedTerm
84 N5aacba2a02214f77a92ba19318ada547 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Phosphorylation
86 rdf:type schema:DefinedTerm
87 N5e2c899feda5488d9624c9b5f7df812d schema:name pubmed_id
88 schema:value 18642117
89 rdf:type schema:PropertyValue
90 N667c51c2c11547e99d376165084ee460 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Hexokinase
92 rdf:type schema:DefinedTerm
93 N7255c2e4e1fe4dba9e617c47813c8ea4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Phosphoprotein Phosphatases
95 rdf:type schema:DefinedTerm
96 N73562cba874947399470e45e3d63e314 schema:name nlm_unique_id
97 schema:value 0364456
98 rdf:type schema:PropertyValue
99 N93e63989dc244088843a9888df9f35a1 schema:name readcube_id
100 schema:value f2823acb486bf1d54461251bcaf3959b8eb94d0162959c40063a28f4e90efafa
101 rdf:type schema:PropertyValue
102 N9a8c5d37a427459f8ac3b8cc80df92c0 schema:name doi
103 schema:value 10.1007/s11010-008-9875-5
104 rdf:type schema:PropertyValue
105 Nab71312c6db7410783be3ade5a60d9fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Hibernation
107 rdf:type schema:DefinedTerm
108 Nade38e4c37b343c1b4ba958051b2a639 schema:issueNumber 1-2
109 rdf:type schema:PublicationIssue
110 Nbeb6474019374e4bbacea4466fdd1e88 rdf:first sg:person.0601365426.50
111 rdf:rest rdf:nil
112 Nc2d82b1cb5af4721851eaf92deee488e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Muscle, Skeletal
114 rdf:type schema:DefinedTerm
115 Nf304768b7cb541e2999745f5d74e1c18 schema:name Springer Nature - SN SciGraph project
116 rdf:type schema:Organization
117 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
118 schema:name Biological Sciences
119 rdf:type schema:DefinedTerm
120 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
121 schema:name Biochemistry and Cell Biology
122 rdf:type schema:DefinedTerm
123 sg:journal.1016672 schema:issn 0300-8177
124 1573-4919
125 schema:name Molecular and Cellular Biochemistry
126 rdf:type schema:Periodical
127 sg:person.01106117210.43 schema:affiliation https://www.grid.ac/institutes/grid.34428.39
128 schema:familyName Abnous
129 schema:givenName Khalil
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106117210.43
131 rdf:type schema:Person
132 sg:person.0601365426.50 schema:affiliation https://www.grid.ac/institutes/grid.34428.39
133 schema:familyName Storey
134 schema:givenName Kenneth B.
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601365426.50
136 rdf:type schema:Person
137 sg:pub.10.1007/978-1-4419-8997-0_3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019997045
138 https://doi.org/10.1007/978-1-4419-8997-0_3
139 rdf:type schema:CreativeWork
140 sg:pub.10.1007/bfb0049776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051254770
141 https://doi.org/10.1007/bfb0049776
142 rdf:type schema:CreativeWork
143 sg:pub.10.1007/s003600050172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031680174
144 https://doi.org/10.1007/s003600050172
145 rdf:type schema:CreativeWork
146 sg:pub.10.1038/nmeth740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021261365
147 https://doi.org/10.1038/nmeth740
148 rdf:type schema:CreativeWork
149 https://app.dimensions.ai/details/publication/pub.1076636206 schema:CreativeWork
150 https://app.dimensions.ai/details/publication/pub.1080203845 schema:CreativeWork
151 https://app.dimensions.ai/details/publication/pub.1082545110 schema:CreativeWork
152 https://doi.org/10.1006/abbi.1999.1686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030496190
153 rdf:type schema:CreativeWork
154 https://doi.org/10.1006/bbrc.1998.9960 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042450783
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1016/0003-9861(85)90633-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027325843
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1016/0006-291x(64)90038-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024193197
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1016/j.abb.2007.07.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021738471
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1016/s0300-9629(97)00238-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046237713
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1017/s1464793103006195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007197914
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1042/bst0250103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019752700
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1073/pnas.54.4.1218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048427012
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1139/o00-086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001778113
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1146/annurev.physiol.66.032102.115105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028138749
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1152/ajpendo.00278.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003080469
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1152/jappl.1999.87.5.1990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074550496
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1158/0008-5472.can-05-1925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024115884
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1242/jeb.00241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036565895
181 rdf:type schema:CreativeWork
182 https://doi.org/10.2337/diabetes.50.6.1253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022984823
183 rdf:type schema:CreativeWork
184 https://www.grid.ac/institutes/grid.34428.39 schema:alternateName Carleton University
185 schema:name Institute of Biochemistry and Department of Chemistry, Carleton University, 1125 Colonel By Drive, K1S 5B6, Ottawa, ON, Canada
186 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...