BRD7 suppresses the growth of Nasopharyngeal Carcinoma cells (HNE1) through negatively regulating β-catenin and ERK pathways View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-04-26

AUTHORS

Cong Peng, Hua Ying Liu, Ming Zhou, Li Ming Zhang, Xiao Ling Li, Shou Rong Shen, Gui Yuan Li

ABSTRACT

BRD7 is a novel gene which involved NPC in our lab. Our previous studies showed that BRD7 was expressed at high level in normal nasopharyngeal epithelial tissues, but at low level in nasopharyngeal carcinoma biopsies and cell lines. In these papers, we found that ectopic expression of BRD7 can decrease cell proliferation and capability to form colonies in soft agar. FCM (Flow cytometry) assay indicated that the cell cycle progression from G1 to S phase was inhibited and the expression of cyclinD1 was significantly decreased after being transfected with BRD7 in HNE1 cells (NPC cells). To further investigate the molecular mechanism of BRD7 suppression of NPC cells growth, the cDNA microarray was performed to detect difference in gene expression profile induced by BRD7. The results indicated that 21 genes expression were changed after being transfected with BRD7 and the differentially expressed gene including α-catenin, cyclinD1, E2F3 was confirmed by western-blot. Next, we found that even though no obvious changes of the total expression of β-catenin were observed, the accumulation of β-catenin in nucleus was blocked. In addition, it was found that the expression of β-catenin was up-regulated in the complex composed of β-catenin and α-catenin in HNE1 cells induction of BRD7. So, we concluded that over-expression of BRD7 increased the expression of α-catenin which “hold” β-catenin in the complex and inhibited its accumulating in nucleus. At last, we demonstrated the c-jun, p-MEK, and p-ERK1/2 expression were down-regulated, and the Ap-1 promoter activity was inactive after being transfected with BRD7. We also found that over-expression of BRD7 can inactivate the c-jun and p-ERK1/2 after being treated with EGF in HNE1 cells. These results indicated that BRD7 played a negative role in ERK1/2 pathway. Taken together, our present results provide new insights for BRD7 function to inhibit NPC cells growth through negative regulating β-catenin and ERK1/2 pathways. More... »

PAGES

141-149

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11010-007-9466-x

DOI

http://dx.doi.org/10.1007/s11010-007-9466-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008996477

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17458518


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Nucleus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomal Proteins, Non-Histone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin D1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoprecipitation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinase 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinase 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nasopharyngeal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligonucleotide Array Sequence Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "beta Catenin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Cancer Research Institute, Central South University, 410078, Changsha, Hunan, China", 
          "id": "http://www.grid.ac/institutes/grid.216417.7", 
          "name": [
            "Cancer Research Institute, Central South University, 410078, Changsha, Hunan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peng", 
        "givenName": "Cong", 
        "id": "sg:person.0715767315.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715767315.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Research Institute, Central South University, 410078, Changsha, Hunan, China", 
          "id": "http://www.grid.ac/institutes/grid.216417.7", 
          "name": [
            "Cancer Research Institute, Central South University, 410078, Changsha, Hunan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Hua Ying", 
        "id": "sg:person.01277404050.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277404050.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Research Institute, Central South University, 410078, Changsha, Hunan, China", 
          "id": "http://www.grid.ac/institutes/grid.216417.7", 
          "name": [
            "Cancer Research Institute, Central South University, 410078, Changsha, Hunan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Ming", 
        "id": "sg:person.01075456274.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075456274.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Research Institute, Central South University, 410078, Changsha, Hunan, China", 
          "id": "http://www.grid.ac/institutes/grid.216417.7", 
          "name": [
            "Cancer Research Institute, Central South University, 410078, Changsha, Hunan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Li Ming", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Research Institute, Central South University, 410078, Changsha, Hunan, China", 
          "id": "http://www.grid.ac/institutes/grid.216417.7", 
          "name": [
            "Cancer Research Institute, Central South University, 410078, Changsha, Hunan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Xiao Ling", 
        "id": "sg:person.01077226116.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077226116.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Third Xiang Ya Hospital, Central South University, Changsha, Hunan, China", 
          "id": "http://www.grid.ac/institutes/grid.216417.7", 
          "name": [
            "The Third Xiang Ya Hospital, Central South University, Changsha, Hunan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shen", 
        "givenName": "Shou Rong", 
        "id": "sg:person.0711411307.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711411307.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Research Institute, Central South University, 410078, Changsha, Hunan, China", 
          "id": "http://www.grid.ac/institutes/grid.216417.7", 
          "name": [
            "Cancer Research Institute, Central South University, 410078, Changsha, Hunan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Gui Yuan", 
        "id": "sg:person.0765070774.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765070774.37"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/35077219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021204853", 
          "https://doi.org/10.1038/35077219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng932", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012439948", 
          "https://doi.org/10.1038/ng932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1360/02yc9060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1065066533", 
          "https://doi.org/10.1360/02yc9060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35074500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013717568", 
          "https://doi.org/10.1038/35074500"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-04-26", 
    "datePublishedReg": "2007-04-26", 
    "description": "BRD7 is a novel gene which involved NPC in our lab. Our previous studies showed that BRD7 was expressed at high level in normal nasopharyngeal epithelial tissues, but at low level in nasopharyngeal carcinoma biopsies and cell lines. In these papers, we found that ectopic expression of BRD7 can decrease cell proliferation and capability to form colonies in soft agar. FCM (Flow cytometry) assay indicated that the cell cycle progression from G1 to S phase was inhibited and the expression of cyclinD1 was significantly decreased after being transfected with BRD7 in HNE1 cells (NPC cells). To further investigate the molecular mechanism of BRD7 suppression of NPC cells growth, the cDNA microarray was performed to detect difference in gene expression profile induced by BRD7. The results indicated that 21 genes expression were changed after being transfected with BRD7 and the differentially expressed gene including \u03b1-catenin, cyclinD1, E2F3 was confirmed by western-blot. Next, we found that even though no obvious changes of the total expression of \u03b2-catenin were observed, the accumulation of \u03b2-catenin in nucleus was blocked. In addition, it was found that the expression of \u03b2-catenin was up-regulated in the complex composed of \u03b2-catenin and \u03b1-catenin in HNE1 cells induction of BRD7. So, we concluded that over-expression of BRD7 increased the expression of \u03b1-catenin which \u201chold\u201d \u03b2-catenin in the complex and inhibited its accumulating in nucleus. At last, we demonstrated the c-jun, p-MEK, and p-ERK1/2 expression were down-regulated, and the Ap-1 promoter activity was inactive after being transfected with BRD7. We also found that over-expression of BRD7 can inactivate the c-jun and p-ERK1/2 after being treated with EGF in HNE1 cells. These results indicated that BRD7 played a negative role in ERK1/2 pathway. Taken together, our present results provide new insights for BRD7 function to inhibit NPC cells growth through negative regulating \u03b2-catenin and ERK1/2 pathways.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s11010-007-9466-x", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4924628", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4988485", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4902429", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1016672", 
        "issn": [
          "0300-8177", 
          "1573-4919"
        ], 
        "name": "Molecular and Cellular Biochemistry", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1-2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "303"
      }
    ], 
    "keywords": [
      "\u03b1-catenin", 
      "\u03b2-catenin", 
      "expression of BRD7", 
      "NPC cell growth", 
      "c-Jun", 
      "ERK1/2 pathway", 
      "cell growth", 
      "HNE1 cells", 
      "normal nasopharyngeal epithelial tissues", 
      "gene expression profiles", 
      "cell cycle progression", 
      "novel genes", 
      "cDNA microarray", 
      "nasopharyngeal epithelial tissues", 
      "ectopic expression", 
      "gene expression", 
      "promoter activity", 
      "BRD7 function", 
      "cycle progression", 
      "expression profiles", 
      "molecular mechanisms", 
      "BRD7", 
      "ERK pathway", 
      "nasopharyngeal carcinoma cells", 
      "AP-1 promoter activity", 
      "S phase", 
      "expression of cyclinD1", 
      "soft agar", 
      "cell proliferation", 
      "total expression", 
      "epithelial tissues", 
      "negative role", 
      "cell lines", 
      "p-MEK", 
      "genes", 
      "pathway", 
      "carcinoma cells", 
      "p-ERK1/2", 
      "expression", 
      "new insights", 
      "cells", 
      "p-ERK1/2 expression", 
      "cyclinD1", 
      "growth", 
      "E2F3", 
      "nasopharyngeal carcinoma biopsies", 
      "carcinoma biopsies", 
      "EGF", 
      "microarray", 
      "nucleus", 
      "HNE1", 
      "high levels", 
      "colonies", 
      "low levels", 
      "proliferation", 
      "previous studies", 
      "induction", 
      "accumulation", 
      "G1", 
      "complexes", 
      "agar", 
      "obvious change", 
      "tissue", 
      "insights", 
      "mechanism", 
      "role", 
      "levels", 
      "accumulating", 
      "progression", 
      "lines", 
      "NPC", 
      "suppression", 
      "activity", 
      "function", 
      "present results", 
      "results", 
      "changes", 
      "profile", 
      "addition", 
      "study", 
      "differences", 
      "lab", 
      "FCM", 
      "phase", 
      "capability", 
      "biopsy", 
      "paper"
    ], 
    "name": "BRD7 suppresses the growth of Nasopharyngeal Carcinoma cells (HNE1) through negatively regulating \u03b2-catenin and ERK pathways", 
    "pagination": "141-149", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1008996477"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s11010-007-9466-x"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17458518"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s11010-007-9466-x", 
      "https://app.dimensions.ai/details/publication/pub.1008996477"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_450.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s11010-007-9466-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11010-007-9466-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11010-007-9466-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11010-007-9466-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11010-007-9466-x'


 

This table displays all metadata directly associated to this object as RDF triples.

289 TRIPLES      21 PREDICATES      135 URIs      123 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s11010-007-9466-x schema:about N030981a601774150bb11f7846985d9a6
2 N05da1eaf09b148f49f9905bf6a9c5386
3 N095807a07d1e42568dafbe7c23cb8a25
4 N1583e0d4b20948f3b665a7996e6db4eb
5 N17727c449c994aa0b86b496025a0f5ed
6 N191eb3d48d5b4fcab4fe42ea5d73c563
7 N25b198588cd949ef897ffeef4c1efe0b
8 N2847e08f73864e55a6197cbe4c3dcf2f
9 N2a7561b015e947df8e79f35b386ce4cf
10 N4f6d1063941e444a8c91e56e7973e967
11 N51847f2b714b4f15bec23d993440f6b5
12 N51aa38efa0c243d8a1351d3aade62b1e
13 N527478eebb7c44bc9c01f87bc8c525fb
14 N87ca4f8a9957442da72da3e52bae8a41
15 Nabf92583168446e98bd02fd06f39db36
16 Nae0fc3a461174cae9510f50ed2558e49
17 Nae76ba25b7954fb9b1c40df6731101cc
18 Nb1c2e54c934343e8b926e7ce1da6f1ac
19 Nec2ea50e36064021b171679151d2eeaa
20 anzsrc-for:06
21 anzsrc-for:0601
22 schema:author Nd700dc31018947eda0e30af0e178213c
23 schema:citation sg:pub.10.1038/35074500
24 sg:pub.10.1038/35077219
25 sg:pub.10.1038/ng932
26 sg:pub.10.1360/02yc9060
27 schema:datePublished 2007-04-26
28 schema:datePublishedReg 2007-04-26
29 schema:description BRD7 is a novel gene which involved NPC in our lab. Our previous studies showed that BRD7 was expressed at high level in normal nasopharyngeal epithelial tissues, but at low level in nasopharyngeal carcinoma biopsies and cell lines. In these papers, we found that ectopic expression of BRD7 can decrease cell proliferation and capability to form colonies in soft agar. FCM (Flow cytometry) assay indicated that the cell cycle progression from G1 to S phase was inhibited and the expression of cyclinD1 was significantly decreased after being transfected with BRD7 in HNE1 cells (NPC cells). To further investigate the molecular mechanism of BRD7 suppression of NPC cells growth, the cDNA microarray was performed to detect difference in gene expression profile induced by BRD7. The results indicated that 21 genes expression were changed after being transfected with BRD7 and the differentially expressed gene including α-catenin, cyclinD1, E2F3 was confirmed by western-blot. Next, we found that even though no obvious changes of the total expression of β-catenin were observed, the accumulation of β-catenin in nucleus was blocked. In addition, it was found that the expression of β-catenin was up-regulated in the complex composed of β-catenin and α-catenin in HNE1 cells induction of BRD7. So, we concluded that over-expression of BRD7 increased the expression of α-catenin which “hold” β-catenin in the complex and inhibited its accumulating in nucleus. At last, we demonstrated the c-jun, p-MEK, and p-ERK1/2 expression were down-regulated, and the Ap-1 promoter activity was inactive after being transfected with BRD7. We also found that over-expression of BRD7 can inactivate the c-jun and p-ERK1/2 after being treated with EGF in HNE1 cells. These results indicated that BRD7 played a negative role in ERK1/2 pathway. Taken together, our present results provide new insights for BRD7 function to inhibit NPC cells growth through negative regulating β-catenin and ERK1/2 pathways.
30 schema:genre article
31 schema:isAccessibleForFree false
32 schema:isPartOf N0f678bf21a2645f28c2fe3cc1cb456ba
33 N9c4f1105496a41d09823779c082890dc
34 sg:journal.1016672
35 schema:keywords AP-1 promoter activity
36 BRD7
37 BRD7 function
38 E2F3
39 EGF
40 ERK pathway
41 ERK1/2 pathway
42 FCM
43 G1
44 HNE1
45 HNE1 cells
46 NPC
47 NPC cell growth
48 S phase
49 accumulating
50 accumulation
51 activity
52 addition
53 agar
54 biopsy
55 c-Jun
56 cDNA microarray
57 capability
58 carcinoma biopsies
59 carcinoma cells
60 cell cycle progression
61 cell growth
62 cell lines
63 cell proliferation
64 cells
65 changes
66 colonies
67 complexes
68 cycle progression
69 cyclinD1
70 differences
71 ectopic expression
72 epithelial tissues
73 expression
74 expression of BRD7
75 expression of cyclinD1
76 expression profiles
77 function
78 gene expression
79 gene expression profiles
80 genes
81 growth
82 high levels
83 induction
84 insights
85 lab
86 levels
87 lines
88 low levels
89 mechanism
90 microarray
91 molecular mechanisms
92 nasopharyngeal carcinoma biopsies
93 nasopharyngeal carcinoma cells
94 nasopharyngeal epithelial tissues
95 negative role
96 new insights
97 normal nasopharyngeal epithelial tissues
98 novel genes
99 nucleus
100 obvious change
101 p-ERK1/2
102 p-ERK1/2 expression
103 p-MEK
104 paper
105 pathway
106 phase
107 present results
108 previous studies
109 profile
110 progression
111 proliferation
112 promoter activity
113 results
114 role
115 soft agar
116 study
117 suppression
118 tissue
119 total expression
120 α-catenin
121 β-catenin
122 schema:name BRD7 suppresses the growth of Nasopharyngeal Carcinoma cells (HNE1) through negatively regulating β-catenin and ERK pathways
123 schema:pagination 141-149
124 schema:productId N08d7c5f73024450d8d0339f43eca6766
125 N144a84b2e1f148d09141ef01b6168bfb
126 N42764e75623b43a7a56c636c19c12579
127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008996477
128 https://doi.org/10.1007/s11010-007-9466-x
129 schema:sdDatePublished 2022-10-01T06:34
130 schema:sdLicense https://scigraph.springernature.com/explorer/license/
131 schema:sdPublisher Nd639e3ead7f44076b69318d69cd13a0e
132 schema:url https://doi.org/10.1007/s11010-007-9466-x
133 sgo:license sg:explorer/license/
134 sgo:sdDataset articles
135 rdf:type schema:ScholarlyArticle
136 N030981a601774150bb11f7846985d9a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Nuclear Proteins
138 rdf:type schema:DefinedTerm
139 N05da1eaf09b148f49f9905bf6a9c5386 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Cell Nucleus
141 rdf:type schema:DefinedTerm
142 N08d7c5f73024450d8d0339f43eca6766 schema:name pubmed_id
143 schema:value 17458518
144 rdf:type schema:PropertyValue
145 N095807a07d1e42568dafbe7c23cb8a25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Oligonucleotide Array Sequence Analysis
147 rdf:type schema:DefinedTerm
148 N0f678bf21a2645f28c2fe3cc1cb456ba schema:issueNumber 1-2
149 rdf:type schema:PublicationIssue
150 N144a84b2e1f148d09141ef01b6168bfb schema:name dimensions_id
151 schema:value pub.1008996477
152 rdf:type schema:PropertyValue
153 N1583e0d4b20948f3b665a7996e6db4eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Nasopharyngeal Neoplasms
155 rdf:type schema:DefinedTerm
156 N17727c449c994aa0b86b496025a0f5ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Chromosomal Proteins, Non-Histone
158 rdf:type schema:DefinedTerm
159 N191eb3d48d5b4fcab4fe42ea5d73c563 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Mitogen-Activated Protein Kinase 3
161 rdf:type schema:DefinedTerm
162 N25b198588cd949ef897ffeef4c1efe0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Cyclin D1
164 rdf:type schema:DefinedTerm
165 N2847e08f73864e55a6197cbe4c3dcf2f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Gene Expression Profiling
167 rdf:type schema:DefinedTerm
168 N2a7561b015e947df8e79f35b386ce4cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Gene Expression Regulation, Neoplastic
170 rdf:type schema:DefinedTerm
171 N31ee48d05a9c4a2cafb9c133d19f0335 rdf:first sg:person.0765070774.37
172 rdf:rest rdf:nil
173 N3936bb5e1f63414e80ab670fd06102e1 rdf:first Ndf968a8fcb1a4883ac46d3152ae3a691
174 rdf:rest Nd37ddceab0d64fb78fa2e5798de78139
175 N42764e75623b43a7a56c636c19c12579 schema:name doi
176 schema:value 10.1007/s11010-007-9466-x
177 rdf:type schema:PropertyValue
178 N4d910d6fd08b4bc79798c9f1aecae894 rdf:first sg:person.01075456274.31
179 rdf:rest N3936bb5e1f63414e80ab670fd06102e1
180 N4f6d1063941e444a8c91e56e7973e967 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Molecular Sequence Data
182 rdf:type schema:DefinedTerm
183 N51847f2b714b4f15bec23d993440f6b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Transcription, Genetic
185 rdf:type schema:DefinedTerm
186 N51aa38efa0c243d8a1351d3aade62b1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Tumor Cells, Cultured
188 rdf:type schema:DefinedTerm
189 N527478eebb7c44bc9c01f87bc8c525fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name beta Catenin
191 rdf:type schema:DefinedTerm
192 N87ca4f8a9957442da72da3e52bae8a41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Cell Proliferation
194 rdf:type schema:DefinedTerm
195 N9c4f1105496a41d09823779c082890dc schema:volumeNumber 303
196 rdf:type schema:PublicationVolume
197 Nabf92583168446e98bd02fd06f39db36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Cell Cycle
199 rdf:type schema:DefinedTerm
200 Nae0fc3a461174cae9510f50ed2558e49 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Humans
202 rdf:type schema:DefinedTerm
203 Nae76ba25b7954fb9b1c40df6731101cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Immunoprecipitation
205 rdf:type schema:DefinedTerm
206 Nb1c2e54c934343e8b926e7ce1da6f1ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Mitogen-Activated Protein Kinase 1
208 rdf:type schema:DefinedTerm
209 Nba78b4b3860e40a782f7854cb1986554 rdf:first sg:person.01277404050.70
210 rdf:rest N4d910d6fd08b4bc79798c9f1aecae894
211 Nd37ddceab0d64fb78fa2e5798de78139 rdf:first sg:person.01077226116.59
212 rdf:rest Nff06a49c28d64ef1a1046548da22b2fe
213 Nd639e3ead7f44076b69318d69cd13a0e schema:name Springer Nature - SN SciGraph project
214 rdf:type schema:Organization
215 Nd700dc31018947eda0e30af0e178213c rdf:first sg:person.0715767315.55
216 rdf:rest Nba78b4b3860e40a782f7854cb1986554
217 Ndf968a8fcb1a4883ac46d3152ae3a691 schema:affiliation grid-institutes:grid.216417.7
218 schema:familyName Zhang
219 schema:givenName Li Ming
220 rdf:type schema:Person
221 Nec2ea50e36064021b171679151d2eeaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Signal Transduction
223 rdf:type schema:DefinedTerm
224 Nff06a49c28d64ef1a1046548da22b2fe rdf:first sg:person.0711411307.07
225 rdf:rest N31ee48d05a9c4a2cafb9c133d19f0335
226 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
227 schema:name Biological Sciences
228 rdf:type schema:DefinedTerm
229 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
230 schema:name Biochemistry and Cell Biology
231 rdf:type schema:DefinedTerm
232 sg:grant.4902429 http://pending.schema.org/fundedItem sg:pub.10.1007/s11010-007-9466-x
233 rdf:type schema:MonetaryGrant
234 sg:grant.4924628 http://pending.schema.org/fundedItem sg:pub.10.1007/s11010-007-9466-x
235 rdf:type schema:MonetaryGrant
236 sg:grant.4988485 http://pending.schema.org/fundedItem sg:pub.10.1007/s11010-007-9466-x
237 rdf:type schema:MonetaryGrant
238 sg:journal.1016672 schema:issn 0300-8177
239 1573-4919
240 schema:name Molecular and Cellular Biochemistry
241 schema:publisher Springer Nature
242 rdf:type schema:Periodical
243 sg:person.01075456274.31 schema:affiliation grid-institutes:grid.216417.7
244 schema:familyName Zhou
245 schema:givenName Ming
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075456274.31
247 rdf:type schema:Person
248 sg:person.01077226116.59 schema:affiliation grid-institutes:grid.216417.7
249 schema:familyName Li
250 schema:givenName Xiao Ling
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077226116.59
252 rdf:type schema:Person
253 sg:person.01277404050.70 schema:affiliation grid-institutes:grid.216417.7
254 schema:familyName Liu
255 schema:givenName Hua Ying
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277404050.70
257 rdf:type schema:Person
258 sg:person.0711411307.07 schema:affiliation grid-institutes:grid.216417.7
259 schema:familyName Shen
260 schema:givenName Shou Rong
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711411307.07
262 rdf:type schema:Person
263 sg:person.0715767315.55 schema:affiliation grid-institutes:grid.216417.7
264 schema:familyName Peng
265 schema:givenName Cong
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715767315.55
267 rdf:type schema:Person
268 sg:person.0765070774.37 schema:affiliation grid-institutes:grid.216417.7
269 schema:familyName Li
270 schema:givenName Gui Yuan
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765070774.37
272 rdf:type schema:Person
273 sg:pub.10.1038/35074500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013717568
274 https://doi.org/10.1038/35074500
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/35077219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021204853
277 https://doi.org/10.1038/35077219
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/ng932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012439948
280 https://doi.org/10.1038/ng932
281 rdf:type schema:CreativeWork
282 sg:pub.10.1360/02yc9060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1065066533
283 https://doi.org/10.1360/02yc9060
284 rdf:type schema:CreativeWork
285 grid-institutes:grid.216417.7 schema:alternateName Cancer Research Institute, Central South University, 410078, Changsha, Hunan, China
286 The Third Xiang Ya Hospital, Central South University, Changsha, Hunan, China
287 schema:name Cancer Research Institute, Central South University, 410078, Changsha, Hunan, China
288 The Third Xiang Ya Hospital, Central South University, Changsha, Hunan, China
289 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...