Ribavirin enhances osteoclast formation through osteoblasts via up-regulation of TRANCE/RANKL View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-02

AUTHORS

Junwon Lee, Jung Ha Kim, Kabsun Kim, Hey Mi Jin, Keun Bae Lee, Dong Jin Chung, Nacksung Kim

ABSTRACT

Hepatitis C combination therapy comprising ribavirin and interferon-alpha causes dramatic improvement with the sustained virological response; however, this treatment may result in the loss of bone mineral density. To investigate the effects of ribavirin on bone cells, we examined osteoblast differentiation as well as the formation of osteoclasts from their precursors. Ribavirin enhances osteoclast formation through osteoblasts by up-regulation of TRANCE/RANKL gene expression, whereas it has no significant effect on either osteoblast differentiation or on bone formation. Understanding ribavirin's underlying mechanism of action on bone cells will enable the improved management of bone loss in chronic hepatitis C patients. More... »

PAGES

17-24

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11010-006-9293-5

DOI

http://dx.doi.org/10.1007/s11010-006-9293-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005664722

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16909305


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