Brief antecedent anoxia preserves mitochondrial function after sustained undersupply: A subcellular correlate to ischemic preconditioning? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-04

AUTHORS

Sven Y. Vetter, Albrecht Elsässer, Osman Tutdibi, Sabrina Lang, Wolfgang Schoels, Anja Pott, Cordula Ackermann, Constanze Reinhard, Felix Wieland, Hugo A. Katus, Wolfgang Kübler, Achim M. Vogt

ABSTRACT

BACKGROUND: There is increasing evidence that mitochondria - owning a high degree of autonomy within the cell - might represent the target organelles of the myocardial protection afforded by ischemic preconditioning. It was the aim of the study to investigate a possible subcellular correlate to ischemic preconditioning at the mitochondrial level. In addition, we tested whether this protection depends on mitochondrial ATP-dependent potassium channels (K (ATP)) and an might involve an attenuation of mitochondrial ATP hydrolysis during sustained anoxia. METHODS AND RESULTS: Sustained anoxia (A, 14 min) and reoxygenation (R) completely inhibited state 3 and state 4 respiration of isolated ventricular mitochondria from Wistar rats. An antecedent brief anoxic incubation (4 min) followed by reoxygenation (2 min) prevented this loss of mitochondrial function. The protection afforded by anoxic preconditioning could be mimicked by the K (ATP) opener diazoxide (30 micromol/l) and was completely inhibited by the K (ATP) blocker 5-hydroxydecanoic acid (300 micromol/l). Structural mitochondrial integrity, as estimated from externalization of the mitochondrial enzymes creatine kinase and glutamateoxalacetate transaminase, remained unchanged between the groups, as did mitochondrial ATP loss during anoxia. CONCLUSION: For the first time, we provide direct evidence for a subcellular preconditioning-like functional mitochondrial adaptation to sustained anoxia. This effect apparently depends on opening of K(ATP) but is independent of ATP preservation. More... »

PAGES

191-196

References to SciGraph publications

  • 1978-12. Studies on the pathogenesis of ischemic cell injury in VIRCHOWS ARCHIV B CELL PATHOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11010-005-9071-9

    DOI

    http://dx.doi.org/10.1007/s11010-005-9071-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031459173

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16477372


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    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s11010-005-9071-9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s11010-005-9071-9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s11010-005-9071-9'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s11010-005-9071-9'


     

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