Urinary liver-type fatty acid binding protein as a useful biomarker in chronic kidney disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-03

AUTHORS

Atsuko Kamijo, Takeshi Sugaya, Akihisa Hikawa, Masaya Yamanouchi, Yasunobu Hirata, Toshihiko Ishimitsu, Atsushi Numabe, Masao Takagi, Hiroshi Hayakawa, Fumiko Tabei, Tokuichiro Sugimoto, Naofumi Mise, Masao Omata, Kenjiro Kimura

ABSTRACT

BACKGROUND: We reported that urinary L-FABP reflected the progression of chronic kidney disease (CKD). This study is aimed to evaluate the clinical significance of urinary liver type fatty acid binding protein (L-FABP) as a biomarker for monitoring CKD. METHODS: Urinary L-FABP was measured using human L-FABP ELISA kit (CMIC.Co., Ltd., Tokyo, Japan). The relations between urinary L-FABP and clinical parameters were evaluated in non-diabetic CKD (n = 48) for a year. In order to evaluate the influence of serum L-FABP derived from liver upon urinary L-FABP, both serum and urinary L-FABP were simultaneously measured in patients with CKD (n = 73). RESULTS: For monitoring CKD, the cut-off value in urinary L-FABP was determined as 17.4 microg/g.cr. by using a receiver operating characteristics (ROC) curve. Renal function deteriorated significantly more in patients with 'high' urinary L-FABP (n = 36) than in those with 'low' L-FABP (n = 12). The decrease in creatinine clearance was accompanied by an increase in urinary L-FABP, but not in urinary protein. Serum L-FABP in patients with CKD was not correlated with urinary L-FABP. CONCLUSION: Urinary excretion of L-FABP increases with the deterioration of renal function. Serum L-FABP did not influence on urinary L-FABP. Urinary L-FABP may be a useful clinical biomarker for monitoring CKD. More... »

PAGES

175-182

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11010-005-9047-9

DOI

http://dx.doi.org/10.1007/s11010-005-9047-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030823593

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16532260


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