Carcinogenic effect of nickel compounds View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-11

AUTHORS

Haitian Lu, Xianglin Shi, Max Costa, Chuanshu Huang

ABSTRACT

Nickel is a widely distributed metal that is industrially applied in many forms. Accumulated epidemiological evidence confirms that exposures to nickel compounds are associated with increased nasal and lung cancer incidence, both in mostly occupational exposures. Although the molecular mechanisms by which nickel compounds cause cancer are still under intense investigation, the carcinogenic actions of nickel compounds are thought to involve oxidative stress, genomic DNA damage, epigenetic effects, and the regulation of gene expression by activation of certain transcription factors related to corresponding signal transduction pathways. The present review summarizes our current knowledge on the molecular mechanisms of nickel carcinogenesis, with special emphasis on the role of nickel induced reactive oxygen species (ROS) and signal transduction pathways. More... »

PAGES

45-67

References to SciGraph publications

  • 1998-10-19. Tpl-2 induces IL-2 expression in T-cell lines by triggering multiple signaling pathways that activate NFAT and NF-κB in ONCOGENE
  • 1982-01. Zum Nachweis von Nickel in biologischen Materialien mittels GC, GC-MS und AAS nach einer tödlichen Vergiftung in ANALYTICAL AND BIOANALYTICAL CHEMISTRY
  • 1997-01-30. Suppression of the malignant phenotype of human glioma cells by overexpression of manganese superoxide dismutase in ONCOGENE
  • 1996-07. Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4 in NATURE
  • 2003-01-25. Nickel-induced oxidative stress and effect of antioxidants in human lymphocytes in ARCHIVES OF TOXICOLOGY
  • 1998-03. Stabilization of wild-type p53 by hypoxia-inducible factor 1α in NATURE
  • 2000-08-17. Calcium channels activated by hydrogen peroxide mediate abscisic acid signalling in guard cells in NATURE
  • 1999. CAP43 in METALS AND GENETICS
  • 1994-06. NF-AT components define a family of transcription factors targeted in T-cell activation in NATURE
  • 1978. Lung Tumor Response in Mice to Metals and Metal Salts in INORGANIC AND NUTRITIONAL ASPECTS OF CANCER
  • 1992-06. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation in NATURE
  • 1999-01-07. Mutations in the promoter reveal a cause for the reduced expression of the human manganese superoxide dismutase gene in cancer cells in ONCOGENE
  • 1993-09. The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun in NATURE
  • 2004-01. Molecular biology of nickel carcinogenesis: Identification of differentially expressed genes in morphologically transformed C3H10T1/2 Cl 8 mouse embryo fibroblast cell lines induced by pecific insoluble nickel compounds in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2004-01. Molecular mechanisms of arsenic carcinogenesis in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 1985-06. Electron microscopical findings with special reference to cancer in rats caused by inhalation of nickel oxide in BIOLOGICAL TRACE ELEMENT RESEARCH
  • 1992-04. Nuclear factor of activated T cells contains Fos and Jun in NATURE
  • 2002-01-30. Reactive Oxygen-induced Carcinogenesis Causes Hypermethylation of p16Ink4a and Activation of MAP Kinase in MOLECULAR MEDICINE
  • 2004-01. Reduced Fhit protein expression in nickel-transformed mouse cells and in nickel-induced murine sarcomas in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2002-06-24. The role of NFAT transcription factors in integrin-mediated carcinoma invasion in NATURE CELL BIOLOGY
  • 2003-03-12. Propofol reduces nitric oxide biosynthesis in lipopolysaccharide-activated macrophages by downregulating the expression of inducible nitric oxide synthase in ARCHIVES OF TOXICOLOGY
  • 2001-04-19. Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1 in ONCOGENE
  • 1991-08. Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s11010-005-8215-2

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    http://dx.doi.org/10.1007/s11010-005-8215-2

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    https://www.ncbi.nlm.nih.gov/pubmed/16283514


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    43 schema:description Nickel is a widely distributed metal that is industrially applied in many forms. Accumulated epidemiological evidence confirms that exposures to nickel compounds are associated with increased nasal and lung cancer incidence, both in mostly occupational exposures. Although the molecular mechanisms by which nickel compounds cause cancer are still under intense investigation, the carcinogenic actions of nickel compounds are thought to involve oxidative stress, genomic DNA damage, epigenetic effects, and the regulation of gene expression by activation of certain transcription factors related to corresponding signal transduction pathways. The present review summarizes our current knowledge on the molecular mechanisms of nickel carcinogenesis, with special emphasis on the role of nickel induced reactive oxygen species (ROS) and signal transduction pathways.
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