Possible involvement of glutamic and/or aspartic acid residue(s) and requirement of mitochondrial integrity for the protective effect of creatine against ... View Full Text


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Article Info

DATE

2005-03

AUTHORS

Soumya SinhaRoy, Sambhunath Banerjee, Manju Ray, Subhankar Ray

ABSTRACT

We had previously shown that creatine exerted a protective effect against inhibition of cardiac mitochondrial respiration by methylglyoxal (SinhaRoy S, Biswas S, Ray M, Ray S. Biochem J 372: 661–669, 2003). In the present study, we have investigated the mechanism of this protective effect by specific amino acid modifying reagent and by several compounds, which are structurally related to creatine. The results show that the compounds, which contain guanidine group such as arginine and guanidinopropionic acid, exert a protective effect, which is quantitatively similar to creatine. This result suggests the presence of carboxylic acid(s) such as glutamic and/or aspartic acid(s) in the creatine-binding site, which has been further supported by experiments with N-ethyl-5-phenyl isoxazolium-3′-sulfonate a reagent known to modify these amino acids. Both polarographic and spectrophotometric assays were performed with NADH as respiratory substrate by using a) submitochondrial particles by sonication, b) freeze-thawed mitochondria and c) mitochondria permeabilized by alamethicin treatment. The results of these studies as compared to that of intact mitochondria indicate that structural integrity of mitochondria is essential for the protective effect of creatine. (Mol Cell Biochem 271: 167–176, 2005) More... »

PAGES

167-176

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s11010-005-6277-9

DOI

http://dx.doi.org/10.1007/s11010-005-6277-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024983729

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15881668


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