Ontology type: schema:ScholarlyArticle
2018-04-13
AUTHORSDavid Meridor, Aviv Cohen, Boris Khalfin, Lakshminarasaiah Uppalapati, Roni Kasher, Ilana Nathan, Abraham H. Parola
ABSTRACTUntil recently, necrotic cells death was considered an uncontrolled process. However, evidence was recently presented that necrosis is a regulated process associated with many clinical conditions. Humanin and its derivatives are peptides known for their anti-apoptotic activity against Alzheimer’s disease. Recently, the humanin-derivative AGA(C8R)-HNG17 (PAGASRLLLLTGEIDLP) was found to have protective effect against necrosis in traumatic brain injury model in mice. We have demonstrated now the protective effect of AGA(C8R)-HNG17 against necrosis in a dose dependent manner in HepG2 cells in vitro, where necrosis was induced in a glucose-free medium by chemohypoxia. Moreover, it was further demonstrated in a model of acetaminophen-induced liver injury in C57BL/6J male mice, in vivo. Intraperitoneal administration of the peptide at 10 and 30 mg/kg significantly prevented the increase in two plasma markers for necrosis, alanine aminotransferase (ALT, EC 2.6.1.2) and aspartate aminotransferase (AST, EC 2.6.1.1). Mitochondrial dysfunction is known to be the main cause of hepatic failure. Hence, the protection from liver injury by AGA(C8R)-HNG17, which we have recently found to target the mitochondria, may be mediated by mitochondrial regulation. Currently, there is no effective treatment for liver diseases, in which necrosis is involved. These findings may provide a new anti-necrotic strategy against APAP-induced liver injury and other liver diseases associated with necrosis using AGA(C8R)-HNG17 as a therapeutic agent. More... »
PAGES1-7
http://scigraph.springernature.com/pub.10.1007/s10989-018-9700-2
DOIhttp://dx.doi.org/10.1007/s10989-018-9700-2
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1103251433
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1199",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Other Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Ben-Gurion University of the Negev",
"id": "https://www.grid.ac/institutes/grid.7489.2",
"name": [
"Department of Chemistry, The Faculty of Natural Sciences, Ben-Gurion University of the Negev, P.O.B 653, 8410501, Beersheba, Israel"
],
"type": "Organization"
},
"familyName": "Meridor",
"givenName": "David",
"id": "sg:person.01000721652.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000721652.51"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ben-Gurion University of the Negev",
"id": "https://www.grid.ac/institutes/grid.7489.2",
"name": [
"Department of Chemistry, The Faculty of Natural Sciences, Ben-Gurion University of the Negev, P.O.B 653, 8410501, Beersheba, Israel"
],
"type": "Organization"
},
"familyName": "Cohen",
"givenName": "Aviv",
"id": "sg:person.01157173075.04",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157173075.04"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ben-Gurion University of the Negev",
"id": "https://www.grid.ac/institutes/grid.7489.2",
"name": [
"Department of Chemistry, The Faculty of Natural Sciences, Ben-Gurion University of the Negev, P.O.B 653, 8410501, Beersheba, Israel",
"Department of Clinical Biochemistry and Pharmacology, The Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O.B 653, 8410501, Beersheba, Israel"
],
"type": "Organization"
},
"familyName": "Khalfin",
"givenName": "Boris",
"id": "sg:person.01315041650.09",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01315041650.09"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ben-Gurion University of the Negev",
"id": "https://www.grid.ac/institutes/grid.7489.2",
"name": [
"Department of Clinical Biochemistry and Pharmacology, The Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O.B 653, 8410501, Beersheba, Israel"
],
"type": "Organization"
},
"familyName": "Uppalapati",
"givenName": "Lakshminarasaiah",
"id": "sg:person.0653070200.91",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653070200.91"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ben-Gurion University of the Negev",
"id": "https://www.grid.ac/institutes/grid.7489.2",
"name": [
"Department of Desalination and Water Treatment, Zuckerberg Institute for Water Research, The Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Sde-Boqer Campus, 8499000, Midreshet Ben-Gurion, Israel"
],
"type": "Organization"
},
"familyName": "Kasher",
"givenName": "Roni",
"id": "sg:person.01246621037.11",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246621037.11"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Soroka Medical Center",
"id": "https://www.grid.ac/institutes/grid.412686.f",
"name": [
"Department of Clinical Biochemistry and Pharmacology, The Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O.B 653, 8410501, Beersheba, Israel",
"Institute of Hematology, Soroka University Medical Center, Beersheba, Israel"
],
"type": "Organization"
},
"familyName": "Nathan",
"givenName": "Ilana",
"id": "sg:person.01266227354.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266227354.35"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "New York University Shanghai",
"id": "https://www.grid.ac/institutes/grid.449457.f",
"name": [
"Department of Chemistry, The Faculty of Natural Sciences, Ben-Gurion University of the Negev, P.O.B 653, 8410501, Beersheba, Israel",
"Visiting Professor of Biophysical Chemistry, Director of Natural Sciences, NYU-Shanghai, Shanghai, People\u2019s Republic of China"
],
"type": "Organization"
},
"familyName": "Parola",
"givenName": "Abraham H.",
"id": "sg:person.01154643757.31",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154643757.31"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/j.tem.2013.01.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000610864"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbrc.2004.09.046",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001093806"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cphy.c120020",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003428720"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neuint.2009.11.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004002536"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/taap.1999.8635",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004061795"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.2165/00002018-200528030-00004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005102916",
"https://doi.org/10.2165/00002018-200528030-00004"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.2165/00002018-200528030-00004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005102916",
"https://doi.org/10.2165/00002018-200528030-00004"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/15563650802665587",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006026425"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/hep.21062",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006787547"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/hep.21062",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006787547"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/hep.23476",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008694553"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/hep.23476",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008694553"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/toxsci/kfi164",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009386214"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1124/jpet.102.039453",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010215921"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/jcbfm.2011.53",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010349768"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/jcbfm.2011.53",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010349768"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0022-1759(83)90438-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010442062"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0022-1759(83)90438-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010442062"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.172.11.7078",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013807552"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.fct.2012.12.063",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016116015"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0006334",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016668824"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12035-009-8090-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017041671",
"https://doi.org/10.1007/s12035-009-8090-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12035-009-8090-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017041671",
"https://doi.org/10.1007/s12035-009-8090-z"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/hep.21475",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022464172"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1091/mbc.e09-02-0168",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023145074"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1471-230x-13-21",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025406561",
"https://doi.org/10.1186/1471-230x-13-21"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/toxsci/67.2.322",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025788373"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1478-3231.2008.01934.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026884917"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m411902200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031662138"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature01627",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032325015",
"https://doi.org/10.1038/nature01627"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature01627",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032325015",
"https://doi.org/10.1038/nature01627"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.101133498",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033876856"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.taap.2014.01.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036696123"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1124/jpet.113.205435",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036753012"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1124/jpet.105.088898",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038035057"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/cc11149",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039417921",
"https://doi.org/10.1186/cc11149"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1385/mn:30:3:327",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039511461",
"https://doi.org/10.1385/mn:30:3:327"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/bbrc.2001.4765",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040174047"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.taap.2013.09.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040654554"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/psp.2013.74",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043015330"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bpj.2009.07.026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046934560"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/nen.0b013e31824ea078",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048718472"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0016-5085(95)90032-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049147544"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/03602532.2011.602688",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049771346"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jhep.2004.09.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052355619"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4065/mcp.2009.0534",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053465892"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.2119/molmed.2015.00073",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1068965752",
"https://doi.org/10.2119/molmed.2015.00073"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.2119/molmed.2015.00073",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1068965752",
"https://doi.org/10.2119/molmed.2015.00073"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2174/1574887111666160815102725",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1069215545"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.1996.85.1.0131",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071098077"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.1996.85.1.0131",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071098077"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.1996.85.1.0131",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071098077"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.21-23-09235.2001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074956753"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077028800",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1080564517",
"type": "CreativeWork"
}
],
"datePublished": "2018-04-13",
"datePublishedReg": "2018-04-13",
"description": "Until recently, necrotic cells death was considered an uncontrolled process. However, evidence was recently presented that necrosis is a regulated process associated with many clinical conditions. Humanin and its derivatives are peptides known for their anti-apoptotic activity against Alzheimer\u2019s disease. Recently, the humanin-derivative AGA(C8R)-HNG17 (PAGASRLLLLTGEIDLP) was found to have protective effect against necrosis in traumatic brain injury model in mice. We have demonstrated now the protective effect of AGA(C8R)-HNG17 against necrosis in a dose dependent manner in HepG2 cells in vitro, where necrosis was induced in a glucose-free medium by chemohypoxia. Moreover, it was further demonstrated in a model of acetaminophen-induced liver injury in C57BL/6J male mice, in vivo. Intraperitoneal administration of the peptide at 10 and 30 mg/kg significantly prevented the increase in two plasma markers for necrosis, alanine aminotransferase (ALT, EC 2.6.1.2) and aspartate aminotransferase (AST, EC 2.6.1.1). Mitochondrial dysfunction is known to be the main cause of hepatic failure. Hence, the protection from liver injury by AGA(C8R)-HNG17, which we have recently found to target the mitochondria, may be mediated by mitochondrial regulation. Currently, there is no effective treatment for liver diseases, in which necrosis is involved. These findings may provide a new anti-necrotic strategy against APAP-induced liver injury and other liver diseases associated with necrosis using AGA(C8R)-HNG17 as a therapeutic agent.",
"genre": "research_article",
"id": "sg:pub.10.1007/s10989-018-9700-2",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1297459",
"issn": [
"1573-3149",
"1573-496X"
],
"name": "International Journal of Peptide Research and Therapeutics",
"type": "Periodical"
}
],
"name": "The Protective Effect of Humanin Derivative AGA(C8R)-HNG17 Against Acetaminophen-Induced Liver Injury in Mice",
"pagination": "1-7",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1103251433"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s10989-018-9700-2"
]
},
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"9e70060db8b799430a86064b5004290b814affe5fd1640affb1323ece0eaf7e8"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s10989-018-9700-2",
"https://app.dimensions.ai/details/publication/pub.1103251433"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-16T06:23",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000377_0000000377/records_106822_00000002.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1007%2Fs10989-018-9700-2"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10989-018-9700-2'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10989-018-9700-2'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10989-018-9700-2'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10989-018-9700-2'
This table displays all metadata directly associated to this object as RDF triples.
247 TRIPLES
21 PREDICATES
69 URIs
16 LITERALS
5 BLANK NODES