Exogenous Catalase Stimulates the Polymyxin E-Induced Rapid Killing of Paenibacillus polymyxa View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-12-04

AUTHORS

Zhiliang Yu, Ling Zhang, Wangrong Qin, Jianhua Yin, Juanping Qiu

ABSTRACT

Polymyxin E (colistin) has been considered as an important peptide antibiotic for clinical treatment of Gram-negative pathogens by selectively targeting lipopolysaccharide on the outer membrane. Recent reports showed that colistin can also kill Gram-positive bacteria, but the mechanism of colistin against Gram-positive bacteria remains unclear. In this study, we found that colistin can kill its producer Paenibacillus polymyxa, a Gram-positive bacterium, by both disrupting its cell integrity and inducing oxidative stress. Enhancement of the cell permeability is the major action of colistin against P. polymyxa. In relative, colistin-induced oxidative stress plays an associated role in killing of P. polymyxa. Notably, we, for the first time, found that exogenous catalase is able to intensify the colistin-induced killing by inhibiting the intracellular catalase activity and thus increasing oxidative stress. Our findings would shed light on a not yet clearly described bactericidal mechanism of colistin against Gram-positive bacteria. More importantly, our findings pave the road for the future to lower clinical use of colistin for avoiding bacterial resistance. More... »

PAGES

161-168

References to SciGraph publications

  • 2004-01. Diversity of structures and properties among catalases in CELLULAR AND MOLECULAR LIFE SCIENCES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10989-017-9657-6

    DOI

    http://dx.doi.org/10.1007/s10989-017-9657-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1093155703


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "College of Biotechnology and Bioengineering, Zhejiang University of Technology, 310014, Hangzhou, China", 
              "id": "http://www.grid.ac/institutes/grid.469325.f", 
              "name": [
                "College of Biotechnology and Bioengineering, Zhejiang University of Technology, 310014, Hangzhou, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yu", 
            "givenName": "Zhiliang", 
            "id": "sg:person.01153375044.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153375044.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "College of Biotechnology and Bioengineering, Zhejiang University of Technology, 310014, Hangzhou, China", 
              "id": "http://www.grid.ac/institutes/grid.469325.f", 
              "name": [
                "College of Biotechnology and Bioengineering, Zhejiang University of Technology, 310014, Hangzhou, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Ling", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "College of Biotechnology and Bioengineering, Zhejiang University of Technology, 310014, Hangzhou, China", 
              "id": "http://www.grid.ac/institutes/grid.469325.f", 
              "name": [
                "College of Biotechnology and Bioengineering, Zhejiang University of Technology, 310014, Hangzhou, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Qin", 
            "givenName": "Wangrong", 
            "id": "sg:person.0577316112.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577316112.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "College of Biotechnology and Bioengineering, Zhejiang University of Technology, 310014, Hangzhou, China", 
              "id": "http://www.grid.ac/institutes/grid.469325.f", 
              "name": [
                "College of Biotechnology and Bioengineering, Zhejiang University of Technology, 310014, Hangzhou, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yin", 
            "givenName": "Jianhua", 
            "id": "sg:person.01216337634.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216337634.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "College of Biotechnology and Bioengineering, Zhejiang University of Technology, 310014, Hangzhou, China", 
              "id": "http://www.grid.ac/institutes/grid.469325.f", 
              "name": [
                "College of Biotechnology and Bioengineering, Zhejiang University of Technology, 310014, Hangzhou, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Qiu", 
            "givenName": "Juanping", 
            "id": "sg:person.0612332544.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612332544.03"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00018-003-3206-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034550151", 
              "https://doi.org/10.1007/s00018-003-3206-5"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-12-04", 
        "datePublishedReg": "2017-12-04", 
        "description": "Polymyxin E (colistin) has been considered as an important peptide antibiotic for clinical treatment of Gram-negative pathogens by selectively targeting lipopolysaccharide on the outer membrane. Recent reports showed that colistin can also kill Gram-positive bacteria, but the mechanism of colistin against Gram-positive bacteria remains unclear. In this study, we found that colistin can kill its producer Paenibacillus polymyxa, a Gram-positive bacterium, by both disrupting its cell integrity and inducing oxidative stress. Enhancement of the cell permeability is the major action of colistin against P. polymyxa. In relative, colistin-induced oxidative stress plays an associated role in killing of P. polymyxa. Notably, we, for the first time, found that exogenous catalase is able to intensify the colistin-induced killing by inhibiting the intracellular catalase activity and thus increasing oxidative stress. Our findings would shed light on a not yet clearly described bactericidal mechanism of colistin against Gram-positive bacteria. More importantly, our findings pave the road for the future to lower clinical use of colistin for avoiding bacterial resistance.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s10989-017-9657-6", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.8195658", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1297459", 
            "issn": [
              "1573-3149", 
              "1573-496X"
            ], 
            "name": "International Journal of Peptide Research and Therapeutics", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "25"
          }
        ], 
        "keywords": [
          "oxidative stress", 
          "polymyxin E", 
          "mechanism of colistin", 
          "exogenous catalase", 
          "Gram-negative pathogens", 
          "Gram-positive bacteria", 
          "colistin", 
          "clinical treatment", 
          "clinical use", 
          "rapid killing", 
          "major action", 
          "intracellular catalase activity", 
          "recent reports", 
          "catalase activity", 
          "bacterial resistance", 
          "killing", 
          "bactericidal mechanism", 
          "important peptides", 
          "cell permeability", 
          "cell integrity", 
          "catalase", 
          "Gram-positive bacterium", 
          "findings", 
          "lipopolysaccharide", 
          "treatment", 
          "report", 
          "bacteria", 
          "pathogens", 
          "stress", 
          "mechanism", 
          "peptides", 
          "associated role", 
          "activity", 
          "study", 
          "action", 
          "role", 
          "resistance", 
          "first time", 
          "use", 
          "bacterium", 
          "membrane", 
          "outer membrane", 
          "integrity", 
          "permeability", 
          "time", 
          "Paenibacillus polymyxa", 
          "enhancement", 
          "future", 
          "light", 
          "polymyxa", 
          "road"
        ], 
        "name": "Exogenous Catalase Stimulates the Polymyxin E-Induced Rapid Killing of Paenibacillus polymyxa", 
        "pagination": "161-168", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1093155703"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10989-017-9657-6"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10989-017-9657-6", 
          "https://app.dimensions.ai/details/publication/pub.1093155703"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-05-10T10:18", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_753.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s10989-017-9657-6"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10989-017-9657-6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10989-017-9657-6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10989-017-9657-6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10989-017-9657-6'


     

    This table displays all metadata directly associated to this object as RDF triples.

    142 TRIPLES      22 PREDICATES      77 URIs      68 LITERALS      6 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10989-017-9657-6 schema:about anzsrc-for:06
    2 anzsrc-for:0601
    3 schema:author N8f45fff3dd644f73a5a6d95e0188956b
    4 schema:citation sg:pub.10.1007/s00018-003-3206-5
    5 schema:datePublished 2017-12-04
    6 schema:datePublishedReg 2017-12-04
    7 schema:description Polymyxin E (colistin) has been considered as an important peptide antibiotic for clinical treatment of Gram-negative pathogens by selectively targeting lipopolysaccharide on the outer membrane. Recent reports showed that colistin can also kill Gram-positive bacteria, but the mechanism of colistin against Gram-positive bacteria remains unclear. In this study, we found that colistin can kill its producer Paenibacillus polymyxa, a Gram-positive bacterium, by both disrupting its cell integrity and inducing oxidative stress. Enhancement of the cell permeability is the major action of colistin against P. polymyxa. In relative, colistin-induced oxidative stress plays an associated role in killing of P. polymyxa. Notably, we, for the first time, found that exogenous catalase is able to intensify the colistin-induced killing by inhibiting the intracellular catalase activity and thus increasing oxidative stress. Our findings would shed light on a not yet clearly described bactericidal mechanism of colistin against Gram-positive bacteria. More importantly, our findings pave the road for the future to lower clinical use of colistin for avoiding bacterial resistance.
    8 schema:genre article
    9 schema:inLanguage en
    10 schema:isAccessibleForFree false
    11 schema:isPartOf N7d1433136d3f477080b652e1c1fc4c88
    12 Nea89fee25e384950bd4b771a0c2ff333
    13 sg:journal.1297459
    14 schema:keywords Gram-negative pathogens
    15 Gram-positive bacteria
    16 Gram-positive bacterium
    17 Paenibacillus polymyxa
    18 action
    19 activity
    20 associated role
    21 bacteria
    22 bacterial resistance
    23 bactericidal mechanism
    24 bacterium
    25 catalase
    26 catalase activity
    27 cell integrity
    28 cell permeability
    29 clinical treatment
    30 clinical use
    31 colistin
    32 enhancement
    33 exogenous catalase
    34 findings
    35 first time
    36 future
    37 important peptides
    38 integrity
    39 intracellular catalase activity
    40 killing
    41 light
    42 lipopolysaccharide
    43 major action
    44 mechanism
    45 mechanism of colistin
    46 membrane
    47 outer membrane
    48 oxidative stress
    49 pathogens
    50 peptides
    51 permeability
    52 polymyxa
    53 polymyxin E
    54 rapid killing
    55 recent reports
    56 report
    57 resistance
    58 road
    59 role
    60 stress
    61 study
    62 time
    63 treatment
    64 use
    65 schema:name Exogenous Catalase Stimulates the Polymyxin E-Induced Rapid Killing of Paenibacillus polymyxa
    66 schema:pagination 161-168
    67 schema:productId N24950304ce4e4757a7653e6bc25afa28
    68 N9bb12b86911347eda5f204575964adc1
    69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093155703
    70 https://doi.org/10.1007/s10989-017-9657-6
    71 schema:sdDatePublished 2022-05-10T10:18
    72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    73 schema:sdPublisher N91b31f384aca4bafae7384d5f12bf714
    74 schema:url https://doi.org/10.1007/s10989-017-9657-6
    75 sgo:license sg:explorer/license/
    76 sgo:sdDataset articles
    77 rdf:type schema:ScholarlyArticle
    78 N24950304ce4e4757a7653e6bc25afa28 schema:name doi
    79 schema:value 10.1007/s10989-017-9657-6
    80 rdf:type schema:PropertyValue
    81 N7d1433136d3f477080b652e1c1fc4c88 schema:volumeNumber 25
    82 rdf:type schema:PublicationVolume
    83 N8f45fff3dd644f73a5a6d95e0188956b rdf:first sg:person.01153375044.92
    84 rdf:rest Na4d46dca585045e1b94e615c928dc28a
    85 N91b31f384aca4bafae7384d5f12bf714 schema:name Springer Nature - SN SciGraph project
    86 rdf:type schema:Organization
    87 N960b6a9fb1074030a814d90d801db4cf rdf:first sg:person.0577316112.53
    88 rdf:rest Nce2dc9f1ba9a4082a9635bd392f90b03
    89 N9bb12b86911347eda5f204575964adc1 schema:name dimensions_id
    90 schema:value pub.1093155703
    91 rdf:type schema:PropertyValue
    92 Na4d46dca585045e1b94e615c928dc28a rdf:first Nbde43adedc5e46eaad8cebe06834e17c
    93 rdf:rest N960b6a9fb1074030a814d90d801db4cf
    94 Nbde43adedc5e46eaad8cebe06834e17c schema:affiliation grid-institutes:grid.469325.f
    95 schema:familyName Zhang
    96 schema:givenName Ling
    97 rdf:type schema:Person
    98 Nc72aa6246ae64ba4af5c13cbe08c7845 rdf:first sg:person.0612332544.03
    99 rdf:rest rdf:nil
    100 Nce2dc9f1ba9a4082a9635bd392f90b03 rdf:first sg:person.01216337634.28
    101 rdf:rest Nc72aa6246ae64ba4af5c13cbe08c7845
    102 Nea89fee25e384950bd4b771a0c2ff333 schema:issueNumber 1
    103 rdf:type schema:PublicationIssue
    104 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    105 schema:name Biological Sciences
    106 rdf:type schema:DefinedTerm
    107 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    108 schema:name Biochemistry and Cell Biology
    109 rdf:type schema:DefinedTerm
    110 sg:grant.8195658 http://pending.schema.org/fundedItem sg:pub.10.1007/s10989-017-9657-6
    111 rdf:type schema:MonetaryGrant
    112 sg:journal.1297459 schema:issn 1573-3149
    113 1573-496X
    114 schema:name International Journal of Peptide Research and Therapeutics
    115 schema:publisher Springer Nature
    116 rdf:type schema:Periodical
    117 sg:person.01153375044.92 schema:affiliation grid-institutes:grid.469325.f
    118 schema:familyName Yu
    119 schema:givenName Zhiliang
    120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153375044.92
    121 rdf:type schema:Person
    122 sg:person.01216337634.28 schema:affiliation grid-institutes:grid.469325.f
    123 schema:familyName Yin
    124 schema:givenName Jianhua
    125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216337634.28
    126 rdf:type schema:Person
    127 sg:person.0577316112.53 schema:affiliation grid-institutes:grid.469325.f
    128 schema:familyName Qin
    129 schema:givenName Wangrong
    130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577316112.53
    131 rdf:type schema:Person
    132 sg:person.0612332544.03 schema:affiliation grid-institutes:grid.469325.f
    133 schema:familyName Qiu
    134 schema:givenName Juanping
    135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612332544.03
    136 rdf:type schema:Person
    137 sg:pub.10.1007/s00018-003-3206-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034550151
    138 https://doi.org/10.1007/s00018-003-3206-5
    139 rdf:type schema:CreativeWork
    140 grid-institutes:grid.469325.f schema:alternateName College of Biotechnology and Bioengineering, Zhejiang University of Technology, 310014, Hangzhou, China
    141 schema:name College of Biotechnology and Bioengineering, Zhejiang University of Technology, 310014, Hangzhou, China
    142 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...