Exogenous Catalase Stimulates the Polymyxin E-Induced Rapid Killing of Paenibacillus polymyxa View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-12-04

AUTHORS

Zhiliang Yu, Ling Zhang, Wangrong Qin, Jianhua Yin, Juanping Qiu

ABSTRACT

Polymyxin E (colistin) has been considered as an important peptide antibiotic for clinical treatment of Gram-negative pathogens by selectively targeting lipopolysaccharide on the outer membrane. Recent reports showed that colistin can also kill Gram-positive bacteria, but the mechanism of colistin against Gram-positive bacteria remains unclear. In this study, we found that colistin can kill its producer Paenibacillus polymyxa, a Gram-positive bacterium, by both disrupting its cell integrity and inducing oxidative stress. Enhancement of the cell permeability is the major action of colistin against P. polymyxa. In relative, colistin-induced oxidative stress plays an associated role in killing of P. polymyxa. Notably, we, for the first time, found that exogenous catalase is able to intensify the colistin-induced killing by inhibiting the intracellular catalase activity and thus increasing oxidative stress. Our findings would shed light on a not yet clearly described bactericidal mechanism of colistin against Gram-positive bacteria. More importantly, our findings pave the road for the future to lower clinical use of colistin for avoiding bacterial resistance. More... »

PAGES

161-168

References to SciGraph publications

  • 2004-01. Diversity of structures and properties among catalases in CELLULAR AND MOLECULAR LIFE SCIENCES
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/s10989-017-9657-6

    DOI

    http://dx.doi.org/10.1007/s10989-017-9657-6

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