Intrinsic Amyloidogenic Behavior of Terminally Protected Alzheimer’s Aβ17–21 Peptide: Self-Aggregation and Amyloid-Like Fibril Formation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-01-27

AUTHORS

Debasish Haldar, Arindam Banerjee

ABSTRACT

The terminally protected peptide Boc-Leu-Val-Phe-Phe-Ala-OMe bearing sequence similarity with the central hydrophobic cluster (CHC) of Alzheimer’s Aβ17–21 peptide self-assembles to produce amyloid-like straight unbranched fibrils from organic solvents. The fibrils readily bind with a physiological dye Congo red (CR) and exhibits green gold birefringence under polarized light, a characteristic feature of amyloid plaque obtained from many neurodegenerative diseases. FTIR spectroscopy and in silico energy minimization study shed some light on the antiparallel supramolecular β-sheet aggregation of the peptide. More... »

PAGES

439-446

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10989-006-9072-x

DOI

http://dx.doi.org/10.1007/s10989-006-9072-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040157562


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1101", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Biochemistry and Metabolomics", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "School of Chemical Engineering and Analytical Science, The University of Manchester, Sackville Street, M60 1QD, Manchester, UK", 
          "id": "http://www.grid.ac/institutes/grid.5379.8", 
          "name": [
            "School of Chemical Engineering and Analytical Science, The University of Manchester, Sackville Street, M60 1QD, Manchester, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haldar", 
        "givenName": "Debasish", 
        "id": "sg:person.01055720507.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055720507.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biological Chemistry, Indian Association for the Cultivation of Science, 700 032, Kolkata, Jadavpur, India", 
          "id": "http://www.grid.ac/institutes/grid.417929.0", 
          "name": [
            "Department of Biological Chemistry, Indian Association for the Cultivation of Science, 700 032, Kolkata, Jadavpur, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Banerjee", 
        "givenName": "Arindam", 
        "id": "sg:person.0722330026.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722330026.43"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature02264", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050852561", 
          "https://doi.org/10.1038/nature02264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10989-006-9037-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011221403", 
          "https://doi.org/10.1007/s10989-006-9037-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0798-822", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038769601", 
          "https://doi.org/10.1038/nm0798-822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsb1195-990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015200821", 
          "https://doi.org/10.1038/nsb1195-990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/418729a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009459168", 
          "https://doi.org/10.1038/418729a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn0403-345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029324830", 
          "https://doi.org/10.1038/nn0403-345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00128336", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029899645", 
          "https://doi.org/10.1007/bf00128336"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-01-27", 
    "datePublishedReg": "2007-01-27", 
    "description": "The terminally protected peptide Boc-Leu-Val-Phe-Phe-Ala-OMe bearing sequence similarity with the central hydrophobic cluster (CHC) of Alzheimer\u2019s A\u03b217\u201321 peptide self-assembles to produce amyloid-like straight unbranched fibrils from organic solvents. The fibrils readily bind with a physiological dye Congo red (CR) and exhibits green gold birefringence under polarized light, a characteristic feature of amyloid plaque obtained from many neurodegenerative diseases. FTIR spectroscopy and in silico energy minimization study shed some light on the antiparallel supramolecular \u03b2-sheet aggregation of the peptide.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10989-006-9072-x", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1297459", 
        "issn": [
          "1573-3149", 
          "1573-496X"
        ], 
        "name": "International Journal of Peptide Research and Therapeutics", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "keywords": [
      "central hydrophobic cluster", 
      "physiological dye Congo red", 
      "Congo red", 
      "peptide Boc-Leu", 
      "Self-Aggregation", 
      "energy minimization studies", 
      "dye Congo red", 
      "Boc-Leu", 
      "FTIR spectroscopy", 
      "organic solvents", 
      "sheet aggregation", 
      "A\u03b217", 
      "amyloid-like fibril formation", 
      "amyloidogenic behavior", 
      "minimization studies", 
      "Phe-Ala", 
      "Val-Phe", 
      "unbranched fibrils", 
      "fibril formation", 
      "hydrophobic cluster", 
      "solvent", 
      "spectroscopy", 
      "amyloid plaques", 
      "peptides", 
      "fibrils", 
      "neurodegenerative diseases", 
      "formation", 
      "aggregation", 
      "light", 
      "red", 
      "antiparallel", 
      "birefringence", 
      "disease", 
      "characteristic features", 
      "plaques", 
      "clusters", 
      "behavior", 
      "study", 
      "features", 
      "similarity", 
      "sequence similarity", 
      "OMe bearing sequence similarity", 
      "bearing sequence similarity", 
      "Alzheimer\u2019s A\u03b217", 
      "amyloid-like straight unbranched fibrils", 
      "straight unbranched fibrils", 
      "green gold birefringence", 
      "gold birefringence", 
      "silico energy minimization study", 
      "Intrinsic Amyloidogenic Behavior", 
      "Terminally Protected Alzheimer\u2019s A\u03b217", 
      "Protected Alzheimer\u2019s A\u03b217"
    ], 
    "name": "Intrinsic Amyloidogenic Behavior of Terminally Protected Alzheimer\u2019s A\u03b217\u201321 Peptide: Self-Aggregation and Amyloid-Like Fibril Formation", 
    "pagination": "439-446", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1040157562"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10989-006-9072-x"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10989-006-9072-x", 
      "https://app.dimensions.ai/details/publication/pub.1040157562"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_451.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10989-006-9072-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10989-006-9072-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10989-006-9072-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10989-006-9072-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10989-006-9072-x'


 

This table displays all metadata directly associated to this object as RDF triples.

156 TRIPLES      22 PREDICATES      86 URIs      69 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10989-006-9072-x schema:about anzsrc-for:06
2 anzsrc-for:0601
3 anzsrc-for:11
4 anzsrc-for:1101
5 schema:author N263cac71f32b42728a82e49fe7e9e2d4
6 schema:citation sg:pub.10.1007/bf00128336
7 sg:pub.10.1007/s10989-006-9037-0
8 sg:pub.10.1038/418729a
9 sg:pub.10.1038/nature02264
10 sg:pub.10.1038/nm0798-822
11 sg:pub.10.1038/nn0403-345
12 sg:pub.10.1038/nsb1195-990
13 schema:datePublished 2007-01-27
14 schema:datePublishedReg 2007-01-27
15 schema:description The terminally protected peptide Boc-Leu-Val-Phe-Phe-Ala-OMe bearing sequence similarity with the central hydrophobic cluster (CHC) of Alzheimer’s Aβ17–21 peptide self-assembles to produce amyloid-like straight unbranched fibrils from organic solvents. The fibrils readily bind with a physiological dye Congo red (CR) and exhibits green gold birefringence under polarized light, a characteristic feature of amyloid plaque obtained from many neurodegenerative diseases. FTIR spectroscopy and in silico energy minimization study shed some light on the antiparallel supramolecular β-sheet aggregation of the peptide.
16 schema:genre article
17 schema:inLanguage en
18 schema:isAccessibleForFree false
19 schema:isPartOf Nb87e6c95f87d49d4be64c496c2a588cf
20 Ne7d40a9f9d3546338079cfdb7e29c226
21 sg:journal.1297459
22 schema:keywords Alzheimer’s Aβ17
23 Aβ17
24 Boc-Leu
25 Congo red
26 FTIR spectroscopy
27 Intrinsic Amyloidogenic Behavior
28 OMe bearing sequence similarity
29 Phe-Ala
30 Protected Alzheimer’s Aβ17
31 Self-Aggregation
32 Terminally Protected Alzheimer’s Aβ17
33 Val-Phe
34 aggregation
35 amyloid plaques
36 amyloid-like fibril formation
37 amyloid-like straight unbranched fibrils
38 amyloidogenic behavior
39 antiparallel
40 bearing sequence similarity
41 behavior
42 birefringence
43 central hydrophobic cluster
44 characteristic features
45 clusters
46 disease
47 dye Congo red
48 energy minimization studies
49 features
50 fibril formation
51 fibrils
52 formation
53 gold birefringence
54 green gold birefringence
55 hydrophobic cluster
56 light
57 minimization studies
58 neurodegenerative diseases
59 organic solvents
60 peptide Boc-Leu
61 peptides
62 physiological dye Congo red
63 plaques
64 red
65 sequence similarity
66 sheet aggregation
67 silico energy minimization study
68 similarity
69 solvent
70 spectroscopy
71 straight unbranched fibrils
72 study
73 unbranched fibrils
74 schema:name Intrinsic Amyloidogenic Behavior of Terminally Protected Alzheimer’s Aβ17–21 Peptide: Self-Aggregation and Amyloid-Like Fibril Formation
75 schema:pagination 439-446
76 schema:productId N1878365c9b294c599eb31439eabe0170
77 N542236e22a1e4828b64a89d0bbcdd9e1
78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040157562
79 https://doi.org/10.1007/s10989-006-9072-x
80 schema:sdDatePublished 2021-12-01T19:19
81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
82 schema:sdPublisher Nd848dce2f78e49f7898fa032545625b2
83 schema:url https://doi.org/10.1007/s10989-006-9072-x
84 sgo:license sg:explorer/license/
85 sgo:sdDataset articles
86 rdf:type schema:ScholarlyArticle
87 N1878365c9b294c599eb31439eabe0170 schema:name dimensions_id
88 schema:value pub.1040157562
89 rdf:type schema:PropertyValue
90 N263cac71f32b42728a82e49fe7e9e2d4 rdf:first sg:person.01055720507.53
91 rdf:rest N659356fce6b44116a6246746aecf9822
92 N542236e22a1e4828b64a89d0bbcdd9e1 schema:name doi
93 schema:value 10.1007/s10989-006-9072-x
94 rdf:type schema:PropertyValue
95 N659356fce6b44116a6246746aecf9822 rdf:first sg:person.0722330026.43
96 rdf:rest rdf:nil
97 Nb87e6c95f87d49d4be64c496c2a588cf schema:volumeNumber 13
98 rdf:type schema:PublicationVolume
99 Nd848dce2f78e49f7898fa032545625b2 schema:name Springer Nature - SN SciGraph project
100 rdf:type schema:Organization
101 Ne7d40a9f9d3546338079cfdb7e29c226 schema:issueNumber 3
102 rdf:type schema:PublicationIssue
103 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
104 schema:name Biological Sciences
105 rdf:type schema:DefinedTerm
106 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
107 schema:name Biochemistry and Cell Biology
108 rdf:type schema:DefinedTerm
109 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
110 schema:name Medical and Health Sciences
111 rdf:type schema:DefinedTerm
112 anzsrc-for:1101 schema:inDefinedTermSet anzsrc-for:
113 schema:name Medical Biochemistry and Metabolomics
114 rdf:type schema:DefinedTerm
115 sg:journal.1297459 schema:issn 1573-3149
116 1573-496X
117 schema:name International Journal of Peptide Research and Therapeutics
118 schema:publisher Springer Nature
119 rdf:type schema:Periodical
120 sg:person.01055720507.53 schema:affiliation grid-institutes:grid.5379.8
121 schema:familyName Haldar
122 schema:givenName Debasish
123 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055720507.53
124 rdf:type schema:Person
125 sg:person.0722330026.43 schema:affiliation grid-institutes:grid.417929.0
126 schema:familyName Banerjee
127 schema:givenName Arindam
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722330026.43
129 rdf:type schema:Person
130 sg:pub.10.1007/bf00128336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029899645
131 https://doi.org/10.1007/bf00128336
132 rdf:type schema:CreativeWork
133 sg:pub.10.1007/s10989-006-9037-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011221403
134 https://doi.org/10.1007/s10989-006-9037-0
135 rdf:type schema:CreativeWork
136 sg:pub.10.1038/418729a schema:sameAs https://app.dimensions.ai/details/publication/pub.1009459168
137 https://doi.org/10.1038/418729a
138 rdf:type schema:CreativeWork
139 sg:pub.10.1038/nature02264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050852561
140 https://doi.org/10.1038/nature02264
141 rdf:type schema:CreativeWork
142 sg:pub.10.1038/nm0798-822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038769601
143 https://doi.org/10.1038/nm0798-822
144 rdf:type schema:CreativeWork
145 sg:pub.10.1038/nn0403-345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029324830
146 https://doi.org/10.1038/nn0403-345
147 rdf:type schema:CreativeWork
148 sg:pub.10.1038/nsb1195-990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015200821
149 https://doi.org/10.1038/nsb1195-990
150 rdf:type schema:CreativeWork
151 grid-institutes:grid.417929.0 schema:alternateName Department of Biological Chemistry, Indian Association for the Cultivation of Science, 700 032, Kolkata, Jadavpur, India
152 schema:name Department of Biological Chemistry, Indian Association for the Cultivation of Science, 700 032, Kolkata, Jadavpur, India
153 rdf:type schema:Organization
154 grid-institutes:grid.5379.8 schema:alternateName School of Chemical Engineering and Analytical Science, The University of Manchester, Sackville Street, M60 1QD, Manchester, UK
155 schema:name School of Chemical Engineering and Analytical Science, The University of Manchester, Sackville Street, M60 1QD, Manchester, UK
156 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...