Compatibility study of tobramycin and pharmaceutical excipients using differential scanning calorimetry, FTIR, DRX, and HPLC View Full Text


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Article Info

DATE

2018-04-24

AUTHORS

María A. Rosasco, Silvina L. Bonafede, Sonia N. Faudone, Adriana I. Segall

ABSTRACT

Differential scanning calorimetry (DSC), isothermal stress testing–Fourier transform infrared spectroscopy (IST–FTIR), isothermal stress testing–high-performance liquid chromatography, and powder X-ray diffraction (PDRX) were used as screening techniques for assessing the compatibility of tobramycin with some currently employed ophthalmic excipients. In the first phase of the study, DSC was used as a tool to detect any interaction. The absolute value of the difference between the enthalpy of the pure tobramycin melting peak and that of its melting peak in the different analyzed mixtures was chosen as a parameter of the drug–excipient interaction degree. DSC results demonstrated that benzalkonium chloride, monobasic sodium phosphate, boric acid, edetate disodium, sodium metabisulfite, thimerosal, and potassium sorbate interact with tobramycin. Taking into account these results, it could be suggested that some of the changes observed in the IST–FTIR spectra of binary blends of tobramycin and some of the excipients would account for a possible interaction between the mixture component. In this study, PDRX did not provide much information, since only tobramycin–thimerosal interactions could be detected. DSC and IST–FTIR are suitable and simple methods for the detection of potential incompatibilities between active pharmaceutical ingredient (API) and excipients. More... »

PAGES

1929-1941

References to SciGraph publications

  • 2016-03-01. Compatibility study between diazepam and tablet excipients in JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
  • 2008-01. Compatibility studies between captopril and pharmaceutical excipients used in tablets formulations in JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
  • 2007-01. Thermoanalytical study of fluoxetine hydrochloride in JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
  • 2017-10-12. Solid-state compatibility studies of a drug without melting point in JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
  • 2007-02-26. Compatibility of fibroin/chitosan and fibroin/cellulose blends studied by thermal analysis in JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
  • 2016-08-22. Solid-state characterization and pharmaceutical compatibility between citalopram and excipients using thermal and non-thermal techniques in JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
  • 2015-10-14. Compatibility study between atorvastatin and excipients using DSC and FTIR in JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
  • 2010-06-03. Thermal compatibility studies of nitroimidazoles and excipients in JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
  • 2007-08-23. Thermal studies of pre-formulates of metronidazole obtained by spray drying technique in JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
  • 2009-08-07. Thermal analysis of lipoic acid and evaluation of the compatibility with excipientes in JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
  • 1991-09. Solid-State Properties of Tobramycin in PHARMACEUTICAL RESEARCH
  • 2017-05-06. Compatibility study of rivaroxaban and its pharmaceutical excipients in JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
  • 2008-07-22. Application of thermal analysis in study of binary mixtures with metformin in JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
  • 2008-07-01. Reaction hazard analysis for the thermal decomposition of cumene hydroperoxide in the presence of sodium hydroxide in JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
  • 2006-02-20. Stability evaluation of n-alkyl hyaluronic acid derivates by DSC and TG measurement in JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
  • 2015-09-19. Evaluation of carvedilol compatibility with lipid excipients for the development of lipid-based drug delivery systems in JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
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