Application of thermal analysis to the study of lipidic prodrug incorporation into nanocarriers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-10

AUTHORS

Jennifer Bourgeois, Laure-Anne Pierson, Julien Nicolas, Muriel Lalanne, Patrick Couvreur, Karine Andrieux

ABSTRACT

Anti HIV molecules as numerous drugs cannot efficiently penetrate into the brain. Prodrug synthesis and encapsulation into pegylated nanocarriers have been proposed as an approach for brain delivery. Pegylated polymeric nanoparticles and liposomes were chosen to incorporate glycerolipidic prodrugs of didanosine. Differential scanning calorimetry experiments were performed on mixtures of prodrugs and lipids or polymer in order to study their interaction. The optimal incorporation ratios were determined for each prodrug and compared for both types of nanocarriers. All these results would be used to prepare optimised formulations of didanosine prodrugs loaded into pegylated nanocarriers for brain drug delivery. More... »

PAGES

65

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10973-009-0350-7

DOI

http://dx.doi.org/10.1007/s10973-009-0350-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018048485


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