Design of liposomes containing photopolymerizable phospholipids for triggered release of contents View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-10

AUTHORS

Amichai Yavlovich, Alok Singh, Sergey Tarasov, Jacek Capala, Robert Blumenthal, Anu Puri

ABSTRACT

We describe a novel class of light-triggerable liposomes prepared from a photo-polymerizable phospholipid DC(8,9)PC (1,2- bis (tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine) and DPPC (1,2-Dipalmitoyl-sn-Glycero-3-Phosphocholine). Exposure to UV (254 nm) radiation for 0-45 minutes at 25 degrees C resulted in photo-polymerization of DC(8,9)PC in these liposomes and the release of an encapsulated fluorescent dye (calcein). Kinetics and extents of calcein release correlated with mol% of DC(8,9)PC in the liposomes. Photopolymerization and calcein release occurred only from DPPC/DC(8,9)PC but not from Egg PC/DC(8,9)PC liposomes. Our data indicate that phase separation and packing of polymerizable lipids in the liposome bilayer are major determinants of photo-activation and triggered contents release. More... »

PAGES

97

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10973-009-0228-8

DOI

http://dx.doi.org/10.1007/s10973-009-0228-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033092864

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20160877


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