Wet sol–gel silica matrices as delivery devices for phenytoin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-12-30

AUTHORS

Alexandra Fidalgo, Tessy M. Lopez, Laura M. Ilharco

ABSTRACT

Wet sol–gel silica matrices produced under different hydrolysis conditions were used as delivery devices to the active principle of an antiepileptic drug (phenytoin sodium), encapsulated during the condensation stage. Post-incorporation into dry silica powder was an alternative loading procedure. It was proven by infrared spectroscopy that neither the silica network nor the drug loose integrity by encapsulation. The kinetics of in vitro drug release was studied at 37 °C, to water and to artificial cerebrospinal fluid (ACSF). Emphasis has been given to the release to ACSF under dynamic conditions (with fluid renovation, emulating what occurs in the brain). Different delivery regimes were identified and correlated with the loading method and the matrix structure. Matrices with lower total porosity and smaller average pore size proved to be better for a long term release. Renovation of ACSF is relevant to assure a constant concentration of phenytoin in the vicinity of the device. More... »

PAGES

320-328

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10971-008-1880-3

DOI

http://dx.doi.org/10.1007/s10971-008-1880-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052833975


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