Crystal structure analysis of l-fuculose-1-phosphate aldolase from Thermus thermophilus HB8 and its catalytic action: as explained through in silico View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-06-07

AUTHORS

L. Karthik, M. Nachiappan, D. Velmurugan, J. Jeyakanthan, K. Gunasekaran

ABSTRACT

Fuculose phosphate aldolase catalyzes the reversible cleavage of fuculose-1-phosphate to dihydroxyacetone phosphate and l-lactaldehyde. A tetramer by nature, this enzyme from Thermus thermophilus HB8 represents the group of Class II aldolases. The structure was solved in two different space groups using the crystals obtained from slow evaporation vapour-diffusion and microbatch techniques. The detailed crystallization description has been reported previously. In this study, the structural features of fuculose phosphate aldolase from T. thermophilus have been explored extensively through sequence and structure comparisons with fuculose phosphate aldolases of different species. Finally, an in silico analysis using induced fit docking was attempted to deduce the binding mode of fuculose phosphate aldolase with its natural substrate fuculose-1-phosphate along with a substrate analog dihydroxyacetone phosphate and phosphoglycolohydroxymate—a potential aldolase inhibitor. The results show the mechanism of action may be similar to that of Escherichia coli fuculose aldolase. More... »

PAGES

59-70

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10969-013-9156-8

DOI

http://dx.doi.org/10.1007/s10969-013-9156-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027023866

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23744484


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209 schema:name Department of Bioinformatics, Alagappa University, 630 003, Karaikudi, Tamil Nadu, India
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211 grid-institutes:grid.413015.2 schema:alternateName CAS in Crystallography and Biophysics, University of Madras, Maraimalai Campus, 600 025, Chennai, Tamil Nadu, India
212 schema:name CAS in Crystallography and Biophysics, University of Madras, Maraimalai Campus, 600 025, Chennai, Tamil Nadu, India
213 rdf:type schema:Organization
 




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