The Scottish Structural Proteomics Facility: targets, methods and outputs View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-04-24

AUTHORS

Muse Oke, Lester G. Carter, Kenneth A. Johnson, Huanting Liu, Stephen A. McMahon, Xuan Yan, Melina Kerou, Nadine D. Weikart, Nadia Kadi, Arif Sheikh, Stefan Schmelz, Mark Dorward, Michal Zawadzki, Christopher Cozens, Helen Falconer, Helen Powers, Ian M. Overton, C. A. Johannes van Niekerk, Xu Peng, Prakash Patel, Roger A. Garrett, David Prangishvili, Catherine H. Botting, Peter J. Coote, David T. F. Dryden, Geoffrey J. Barton, Ulrich Schwarz-Linek, Gregory L. Challis, Garry L. Taylor, Malcolm F. White, James H. Naismith

ABSTRACT

The Scottish Structural Proteomics Facility was funded to develop a laboratory scale approach to high throughput structure determination. The effort was successful in that over 40 structures were determined. These structures and the methods harnessed to obtain them are reported here. This report reflects on the value of automation but also on the continued requirement for a high degree of scientific and technical expertise. The efficiency of the process poses challenges to the current paradigm of structural analysis and publication. In the 5 year period we published ten peer-reviewed papers reporting structural data arising from the pipeline. Nevertheless, the number of structures solved exceeded our ability to analyse and publish each new finding. By reporting the experimental details and depositing the structures we hope to maximize the impact of the project by allowing others to follow up the relevant biology. More... »

PAGES

167-180

Journal

Author Affiliations

  • Biomedical Sciences Research Complex, University of St Andrews, St Andrews, KY16 9ST UK
  • Present Address: Stanford Synchrotron Radiation Light Source, 2575 Sand Hill Road, MS 69, Menlo Park, CA 94025 USA
  • Present Address: The Norwegian Structural Biology Centre, University of Tromsø, 9037 Tromsø, Norway
  • Present Address: Faculty of Chemistry, Technische Universität Dortmund, Otto-Hahn-Str. 6, 44227 Dortmund, Germany
  • Present Address: Institute of Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey, SM2 5NG UK
  • Present Address: Division of Signal Transduction Therapy, College of Life Sciences, University of Dundee, Dundee, DD1 5EH Scotland, UK
  • Present Address: Syngenta Ltd, Jealott’s Hill International Research Centre, Bracknell, Berkshire, RG42 6EY UK
  • Present Address: Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH UK
  • Present Address: Institute of Structural and Molecular Biology, Edinburgh University, Kings Buildings, Edinburgh, EH9 3JR UK
  • Present Address: MRC Human Genetics Unit, Crewe Road South, Edinburgh, EH4 2XU UK
  • Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH Scotland, UK
  • Department of Biology, Archaea Centre, University of Copenhagen, Ole Maaløes Vej 5, 2200, Copenhagen N, Denmark
  • Department of Chemistry, University of Warwick, Coventry, CV4 7AL UK
  • Institut Pasteur, 25 rue Dr. Roux, 75724 Paris cedex 15, France
  • EaStChem School of Chemistry, University of Edinburgh, The King’s Buildings, Edinburgh, EH9 3JJ UK
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10969-010-9090-y

    DOI

    http://dx.doi.org/10.1007/s10969-010-9090-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020987767

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20419351


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