Protein Production and Crystallization at the Joint Center for Structural Genomics View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-09

AUTHORS

Scott A. Lesley, Ian A. Wilson

ABSTRACT

By definition, structural genomics centers must be able to address a large number of diverse protein targets. The methods developed should permit parallel and cost-effective processing while allowing for the diverse nature of proteins. Our approach to this problem is a multi-tiered effort where targets are characterized and categorized by behavior and processed in parallel by appropriate methods. The Joint Center for Structural Genomics (JCSG) has applied this tactic to create a fully integrated and scaleable structure determination pipeline. Highlights of the development of the current pipeline for protein production and crystallization are presented here. More... »

PAGES

71-79

References to SciGraph publications

  • 2000-11-01. Automation of X-ray crystallography in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2004-03. A scaleable and integrated crystallization pipeline applied to mining the Thermotoga maritima proteome in JOURNAL OF STRUCTURAL AND FUNCTIONAL GENOMICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10969-005-2897-2

    DOI

    http://dx.doi.org/10.1007/s10969-005-2897-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1043242470

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16211502


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