Preliminary evaluation and in vitro cytotoxicity studies of [131I]I-trastuzumab in HER2 expressing ovarian cancer cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-05-07

AUTHORS

Hao Deng, Wei Liu, Xia Yang, Kehong Li, Wei Liao, Peng Zhao, Yuchuan Yang, Hongyuan Wei, Jing Wang, Yue Chen

ABSTRACT

As trastuzumab is known to target the human epidermal growth factor receptor type (HER2), the potential of [131I]I-trastuzumab as a radioimmunotherapy agent was evaluated in vitro and in vivo for HER2-overexpressing ovarian cancer cells (SKOV-3). [131I]I-trastuzumab showed promising in vitro properties and high tumor uptake in SKOV-3 xenografts. Its cellular toxicity was dose- and time-dependent, and it retained in the SKOV-3 cells in the G2/M phase of cell cycle. The mode of cell death was predominantly by apoptosis. These results demonstrate the potential of [131I]I-trastuzumab for further therapeutic evaluation in HER2-overexpressing ovarian cancers. More... »

PAGES

1-10

References to SciGraph publications

  • 2010-03-27. Trastuzumab Sensitizes Ovarian Cancer Cells to EGFR-targeted Therapeutics in JOURNAL OF OVARIAN RESEARCH
  • 2015-05-22. Radioimmunotherapy of human tumours in NATURE REVIEWS CANCER
  • 2001-02. Untangling the ErbB signalling network in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2014-09-20. 188Re-HYNIC-trastuzumab enhances the effect of apoptosis induced by trastuzumab in HER2-overexpressing breast cancer cells in ANNALS OF NUCLEAR MEDICINE
  • 1999-11-01. Cytotoxic drugs and the CD95 pathway in LEUKEMIA
  • 2003-06-26. Beta-irradiation used for systemic radioimmunotherapy induces apoptosis and activates apoptosis pathways in leukaemia cells in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2000-11-02. A possible role for centrosome overduplication in radiation-induced cell death in ONCOGENE
  • 2014-02-03. Antibody Labeling with Radioiodine and Radiometals in DRUG DELIVERY SYSTEM
  • 2011-03-13. Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways in NATURE MEDICINE
  • 2008-04-11. Death through a tragedy: mitotic catastrophe in CELL DEATH & DIFFERENTIATION
  • 2010-10-10. Inhibition of ErbB2 by Herceptin reduces viability and survival, induces apoptosis and oxidative stress in Calu-3 cell line in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2013-12-20. Ovarian cancer microenvironment: implications for cancer dissemination and chemoresistance acquisition in CANCER AND METASTASIS REVIEWS
  • 2009-12-10. HER2 overexpression and amplification is present in a subset of ovarian mucinous carcinomas and can be targeted with trastuzumab therapy in BMC CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10967-022-08329-7

    DOI

    http://dx.doi.org/10.1007/s10967-022-08329-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1147718675


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Chemical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0301", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Analytical Chemistry", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0302", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Inorganic Chemistry", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0306", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Physical Chemistry (incl. Structural)", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, 621900, Mianyang, China", 
              "id": "http://www.grid.ac/institutes/grid.249079.1", 
              "name": [
                "Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, China", 
                "Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, 621900, Mianyang, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Deng", 
            "givenName": "Hao", 
            "id": "sg:person.011423542267.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011423542267.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, 621900, Mianyang, China", 
              "id": "http://www.grid.ac/institutes/grid.249079.1", 
              "name": [
                "Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, China", 
                "Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, 621900, Mianyang, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liu", 
            "givenName": "Wei", 
            "id": "sg:person.010626161667.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010626161667.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, 621900, Mianyang, China", 
              "id": "http://www.grid.ac/institutes/grid.249079.1", 
              "name": [
                "Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, China", 
                "Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, 621900, Mianyang, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yang", 
            "givenName": "Xia", 
            "id": "sg:person.01073030435.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073030435.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, 621900, Mianyang, China", 
              "id": "http://www.grid.ac/institutes/grid.249079.1", 
              "name": [
                "Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, China", 
                "Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, 621900, Mianyang, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Kehong", 
            "id": "sg:person.014211177176.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014211177176.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, 621900, Mianyang, China", 
              "id": "http://www.grid.ac/institutes/grid.249079.1", 
              "name": [
                "Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, 621900, Mianyang, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liao", 
            "givenName": "Wei", 
            "id": "sg:person.01163732255.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163732255.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, 621900, Mianyang, China", 
              "id": "http://www.grid.ac/institutes/grid.249079.1", 
              "name": [
                "Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, 621900, Mianyang, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhao", 
            "givenName": "Peng", 
            "id": "sg:person.013201262743.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013201262743.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, 621900, Mianyang, China", 
              "id": "http://www.grid.ac/institutes/grid.249079.1", 
              "name": [
                "Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, China", 
                "Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, 621900, Mianyang, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yang", 
            "givenName": "Yuchuan", 
            "id": "sg:person.013346644016.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013346644016.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, 621900, Mianyang, China", 
              "id": "http://www.grid.ac/institutes/grid.249079.1", 
              "name": [
                "Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, China", 
                "Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, 621900, Mianyang, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wei", 
            "givenName": "Hongyuan", 
            "id": "sg:person.01175666253.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175666253.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Key Laboratory of Nuclear Medicine and Molecular Imaging of Sichuan Province, 621999, Mianyang, China", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, 621900, Mianyang, China", 
                "Collaborative Innovation Center of Radiation Medicine of Jiangsu, Higher Education Institutions, 215123, Suzhou, China", 
                "Key Laboratory of Nuclear Medicine and Molecular Imaging of Sichuan Province, 621999, Mianyang, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Jing", 
            "id": "sg:person.010025343047.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010025343047.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, 621900, Mianyang, China", 
              "id": "http://www.grid.ac/institutes/grid.249079.1", 
              "name": [
                "Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, China", 
                "Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, 621900, Mianyang, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Yue", 
            "id": "sg:person.010332655223.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010332655223.38"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/978-1-4939-0363-4_9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042436486", 
              "https://doi.org/10.1007/978-1-4939-0363-4_9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10555-013-9456-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040453486", 
              "https://doi.org/10.1007/s10555-013-9456-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-003-1216-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035739075", 
              "https://doi.org/10.1007/s00259-003-1216-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2008.47", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041213023", 
              "https://doi.org/10.1038/cdd.2008.47"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35052073", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053565592", 
              "https://doi.org/10.1038/35052073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2309", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025284851", 
              "https://doi.org/10.1038/nm.2309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203902", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053497495", 
              "https://doi.org/10.1038/sj.onc.1203902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3925", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051991471", 
              "https://doi.org/10.1038/nrc3925"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1757-2215-3-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024866727", 
              "https://doi.org/10.1186/1757-2215-3-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-9-433", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009316854", 
              "https://doi.org/10.1186/1471-2407-9-433"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11010-010-0610-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012169445", 
              "https://doi.org/10.1007/s11010-010-0610-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.leu.2401333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048909173", 
              "https://doi.org/10.1038/sj.leu.2401333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12149-014-0908-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008983147", 
              "https://doi.org/10.1007/s12149-014-0908-8"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2022-05-07", 
        "datePublishedReg": "2022-05-07", 
        "description": "As trastuzumab is known to target the human epidermal growth factor receptor type (HER2), the potential of [131I]I-trastuzumab as a radioimmunotherapy agent was evaluated in vitro and in vivo for HER2-overexpressing ovarian cancer cells (SKOV-3). [131I]I-trastuzumab showed promising in vitro properties and high tumor uptake in SKOV-3 xenografts. Its cellular toxicity was dose- and time-dependent, and it retained in the SKOV-3 cells in the G2/M phase of cell cycle. The mode of cell death was predominantly by apoptosis. These results demonstrate the potential of [131I]I-trastuzumab for further therapeutic evaluation in HER2-overexpressing ovarian cancers.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s10967-022-08329-7", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.8906371", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.8904488", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.8157431", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1094634", 
            "issn": [
              "0236-5731", 
              "1588-2780"
            ], 
            "name": "Journal of Radioanalytical and Nuclear Chemistry", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }
        ], 
        "keywords": [
          "ovarian cancer cells", 
          "human epidermal growth factor receptor type", 
          "cancer cells", 
          "further therapeutic evaluation", 
          "SKOV-3 xenografts", 
          "high tumor uptake", 
          "SKOV-3 cells", 
          "G2/M phase", 
          "radioimmunotherapy agent", 
          "ovarian cancer", 
          "therapeutic evaluation", 
          "tumor uptake", 
          "trastuzumab", 
          "receptor types", 
          "cell death", 
          "M phase", 
          "cell cycle", 
          "cellular toxicity", 
          "cells", 
          "HER2", 
          "xenografts", 
          "cytotoxicity studies", 
          "cancer", 
          "dose", 
          "death", 
          "vitro", 
          "apoptosis", 
          "vivo", 
          "evaluation", 
          "preliminary evaluation", 
          "toxicity", 
          "agents", 
          "uptake", 
          "study", 
          "potential", 
          "types", 
          "results", 
          "cycle", 
          "phase", 
          "mode", 
          "properties"
        ], 
        "name": "Preliminary evaluation and in vitro cytotoxicity studies of [131I]I-trastuzumab in HER2 expressing ovarian cancer cells", 
        "pagination": "1-10", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1147718675"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10967-022-08329-7"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10967-022-08329-7", 
          "https://app.dimensions.ai/details/publication/pub.1147718675"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-06-01T22:25", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_926.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s10967-022-08329-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10967-022-08329-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10967-022-08329-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10967-022-08329-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10967-022-08329-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    228 TRIPLES      22 PREDICATES      79 URIs      56 LITERALS      4 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10967-022-08329-7 schema:about anzsrc-for:03
    2 anzsrc-for:0301
    3 anzsrc-for:0302
    4 anzsrc-for:0306
    5 schema:author N275975320bca41dfa812e7521f828b96
    6 schema:citation sg:pub.10.1007/978-1-4939-0363-4_9
    7 sg:pub.10.1007/s00259-003-1216-z
    8 sg:pub.10.1007/s10555-013-9456-2
    9 sg:pub.10.1007/s11010-010-0610-7
    10 sg:pub.10.1007/s12149-014-0908-8
    11 sg:pub.10.1038/35052073
    12 sg:pub.10.1038/cdd.2008.47
    13 sg:pub.10.1038/nm.2309
    14 sg:pub.10.1038/nrc3925
    15 sg:pub.10.1038/sj.leu.2401333
    16 sg:pub.10.1038/sj.onc.1203902
    17 sg:pub.10.1186/1471-2407-9-433
    18 sg:pub.10.1186/1757-2215-3-7
    19 schema:datePublished 2022-05-07
    20 schema:datePublishedReg 2022-05-07
    21 schema:description As trastuzumab is known to target the human epidermal growth factor receptor type (HER2), the potential of [131I]I-trastuzumab as a radioimmunotherapy agent was evaluated in vitro and in vivo for HER2-overexpressing ovarian cancer cells (SKOV-3). [131I]I-trastuzumab showed promising in vitro properties and high tumor uptake in SKOV-3 xenografts. Its cellular toxicity was dose- and time-dependent, and it retained in the SKOV-3 cells in the G2/M phase of cell cycle. The mode of cell death was predominantly by apoptosis. These results demonstrate the potential of [131I]I-trastuzumab for further therapeutic evaluation in HER2-overexpressing ovarian cancers.
    22 schema:genre article
    23 schema:inLanguage en
    24 schema:isAccessibleForFree false
    25 schema:isPartOf sg:journal.1094634
    26 schema:keywords G2/M phase
    27 HER2
    28 M phase
    29 SKOV-3 cells
    30 SKOV-3 xenografts
    31 agents
    32 apoptosis
    33 cancer
    34 cancer cells
    35 cell cycle
    36 cell death
    37 cells
    38 cellular toxicity
    39 cycle
    40 cytotoxicity studies
    41 death
    42 dose
    43 evaluation
    44 further therapeutic evaluation
    45 high tumor uptake
    46 human epidermal growth factor receptor type
    47 mode
    48 ovarian cancer
    49 ovarian cancer cells
    50 phase
    51 potential
    52 preliminary evaluation
    53 properties
    54 radioimmunotherapy agent
    55 receptor types
    56 results
    57 study
    58 therapeutic evaluation
    59 toxicity
    60 trastuzumab
    61 tumor uptake
    62 types
    63 uptake
    64 vitro
    65 vivo
    66 xenografts
    67 schema:name Preliminary evaluation and in vitro cytotoxicity studies of [131I]I-trastuzumab in HER2 expressing ovarian cancer cells
    68 schema:pagination 1-10
    69 schema:productId N0f88ecffd2b64cf089cf33b0375bd07e
    70 N6b7aab4e8db94375abb406cde6f35168
    71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1147718675
    72 https://doi.org/10.1007/s10967-022-08329-7
    73 schema:sdDatePublished 2022-06-01T22:25
    74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    75 schema:sdPublisher N47bc5c353bf145f4af26a519b26cacba
    76 schema:url https://doi.org/10.1007/s10967-022-08329-7
    77 sgo:license sg:explorer/license/
    78 sgo:sdDataset articles
    79 rdf:type schema:ScholarlyArticle
    80 N02fe8ad321b84611b4431dbd8d08e91b rdf:first sg:person.010025343047.32
    81 rdf:rest N821fbc04f0fc41eb90141b9805e614e3
    82 N0f88ecffd2b64cf089cf33b0375bd07e schema:name doi
    83 schema:value 10.1007/s10967-022-08329-7
    84 rdf:type schema:PropertyValue
    85 N275975320bca41dfa812e7521f828b96 rdf:first sg:person.011423542267.19
    86 rdf:rest Na7797a4f33574530afbf1ae1478d13a3
    87 N47bc5c353bf145f4af26a519b26cacba schema:name Springer Nature - SN SciGraph project
    88 rdf:type schema:Organization
    89 N555e742b1254488c90a29a2ad87f8aee rdf:first sg:person.01073030435.99
    90 rdf:rest Ne72f6825dd7e43188810b5da868bd967
    91 N65ccca9c630d472198b7b71bf3c5e7ad rdf:first sg:person.013346644016.10
    92 rdf:rest N6a5242c71f0b4585b5297f68bf43a364
    93 N6a5242c71f0b4585b5297f68bf43a364 rdf:first sg:person.01175666253.74
    94 rdf:rest N02fe8ad321b84611b4431dbd8d08e91b
    95 N6b7aab4e8db94375abb406cde6f35168 schema:name dimensions_id
    96 schema:value pub.1147718675
    97 rdf:type schema:PropertyValue
    98 N821fbc04f0fc41eb90141b9805e614e3 rdf:first sg:person.010332655223.38
    99 rdf:rest rdf:nil
    100 N83c5f86cfd56452eac4366d1a84fb555 rdf:first sg:person.013201262743.92
    101 rdf:rest N65ccca9c630d472198b7b71bf3c5e7ad
    102 Na7797a4f33574530afbf1ae1478d13a3 rdf:first sg:person.010626161667.75
    103 rdf:rest N555e742b1254488c90a29a2ad87f8aee
    104 Nac0cc27c4ae74359bf3b86f495e6481c rdf:first sg:person.01163732255.01
    105 rdf:rest N83c5f86cfd56452eac4366d1a84fb555
    106 Ne72f6825dd7e43188810b5da868bd967 rdf:first sg:person.014211177176.03
    107 rdf:rest Nac0cc27c4ae74359bf3b86f495e6481c
    108 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
    109 schema:name Chemical Sciences
    110 rdf:type schema:DefinedTerm
    111 anzsrc-for:0301 schema:inDefinedTermSet anzsrc-for:
    112 schema:name Analytical Chemistry
    113 rdf:type schema:DefinedTerm
    114 anzsrc-for:0302 schema:inDefinedTermSet anzsrc-for:
    115 schema:name Inorganic Chemistry
    116 rdf:type schema:DefinedTerm
    117 anzsrc-for:0306 schema:inDefinedTermSet anzsrc-for:
    118 schema:name Physical Chemistry (incl. Structural)
    119 rdf:type schema:DefinedTerm
    120 sg:grant.8157431 http://pending.schema.org/fundedItem sg:pub.10.1007/s10967-022-08329-7
    121 rdf:type schema:MonetaryGrant
    122 sg:grant.8904488 http://pending.schema.org/fundedItem sg:pub.10.1007/s10967-022-08329-7
    123 rdf:type schema:MonetaryGrant
    124 sg:grant.8906371 http://pending.schema.org/fundedItem sg:pub.10.1007/s10967-022-08329-7
    125 rdf:type schema:MonetaryGrant
    126 sg:journal.1094634 schema:issn 0236-5731
    127 1588-2780
    128 schema:name Journal of Radioanalytical and Nuclear Chemistry
    129 schema:publisher Springer Nature
    130 rdf:type schema:Periodical
    131 sg:person.010025343047.32 schema:affiliation grid-institutes:None
    132 schema:familyName Wang
    133 schema:givenName Jing
    134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010025343047.32
    135 rdf:type schema:Person
    136 sg:person.010332655223.38 schema:affiliation grid-institutes:grid.249079.1
    137 schema:familyName Chen
    138 schema:givenName Yue
    139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010332655223.38
    140 rdf:type schema:Person
    141 sg:person.010626161667.75 schema:affiliation grid-institutes:grid.249079.1
    142 schema:familyName Liu
    143 schema:givenName Wei
    144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010626161667.75
    145 rdf:type schema:Person
    146 sg:person.01073030435.99 schema:affiliation grid-institutes:grid.249079.1
    147 schema:familyName Yang
    148 schema:givenName Xia
    149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073030435.99
    150 rdf:type schema:Person
    151 sg:person.011423542267.19 schema:affiliation grid-institutes:grid.249079.1
    152 schema:familyName Deng
    153 schema:givenName Hao
    154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011423542267.19
    155 rdf:type schema:Person
    156 sg:person.01163732255.01 schema:affiliation grid-institutes:grid.249079.1
    157 schema:familyName Liao
    158 schema:givenName Wei
    159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163732255.01
    160 rdf:type schema:Person
    161 sg:person.01175666253.74 schema:affiliation grid-institutes:grid.249079.1
    162 schema:familyName Wei
    163 schema:givenName Hongyuan
    164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175666253.74
    165 rdf:type schema:Person
    166 sg:person.013201262743.92 schema:affiliation grid-institutes:grid.249079.1
    167 schema:familyName Zhao
    168 schema:givenName Peng
    169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013201262743.92
    170 rdf:type schema:Person
    171 sg:person.013346644016.10 schema:affiliation grid-institutes:grid.249079.1
    172 schema:familyName Yang
    173 schema:givenName Yuchuan
    174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013346644016.10
    175 rdf:type schema:Person
    176 sg:person.014211177176.03 schema:affiliation grid-institutes:grid.249079.1
    177 schema:familyName Li
    178 schema:givenName Kehong
    179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014211177176.03
    180 rdf:type schema:Person
    181 sg:pub.10.1007/978-1-4939-0363-4_9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042436486
    182 https://doi.org/10.1007/978-1-4939-0363-4_9
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1007/s00259-003-1216-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1035739075
    185 https://doi.org/10.1007/s00259-003-1216-z
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1007/s10555-013-9456-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040453486
    188 https://doi.org/10.1007/s10555-013-9456-2
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1007/s11010-010-0610-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012169445
    191 https://doi.org/10.1007/s11010-010-0610-7
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1007/s12149-014-0908-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008983147
    194 https://doi.org/10.1007/s12149-014-0908-8
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/35052073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053565592
    197 https://doi.org/10.1038/35052073
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/cdd.2008.47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041213023
    200 https://doi.org/10.1038/cdd.2008.47
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/nm.2309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025284851
    203 https://doi.org/10.1038/nm.2309
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/nrc3925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051991471
    206 https://doi.org/10.1038/nrc3925
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/sj.leu.2401333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048909173
    209 https://doi.org/10.1038/sj.leu.2401333
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1038/sj.onc.1203902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053497495
    212 https://doi.org/10.1038/sj.onc.1203902
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1186/1471-2407-9-433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009316854
    215 https://doi.org/10.1186/1471-2407-9-433
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1186/1757-2215-3-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024866727
    218 https://doi.org/10.1186/1757-2215-3-7
    219 rdf:type schema:CreativeWork
    220 grid-institutes:None schema:alternateName Key Laboratory of Nuclear Medicine and Molecular Imaging of Sichuan Province, 621999, Mianyang, China
    221 schema:name Collaborative Innovation Center of Radiation Medicine of Jiangsu, Higher Education Institutions, 215123, Suzhou, China
    222 Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, 621900, Mianyang, China
    223 Key Laboratory of Nuclear Medicine and Molecular Imaging of Sichuan Province, 621999, Mianyang, China
    224 rdf:type schema:Organization
    225 grid-institutes:grid.249079.1 schema:alternateName Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, 621900, Mianyang, China
    226 schema:name Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, 646000, Luzhou, China
    227 Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, 621900, Mianyang, China
    228 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...