Synthesis and in vivo evaluation of 18F-cPNA and Dendrimer-PNA conjugate for amplification pretargeting View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-05-06

AUTHORS

Le Cai, Hong Wang, Shuhua He, Xiaobei Zheng, Yuxia Liu, Lan Zhang

ABSTRACT

Amplification pretargeting strategies have great potential in nuclear medicine to increase the tumoral radioactivity concentration compared to conventional pretargeting. In this work, the dendrimer polyamidoamine generation 4 (PAMAM G4) was conjugated to multiple copies of peptide nucleic acid (PNA) as a signal amplification platform, which could combine with the antibody of CC49-cPNA and the tracer of 18F labeled complementary peptide nucleic acid (18F-cPNA) in biodistribution experiments to determine the signal amplification effect in vivo. The mice in the Amplification Group exhibited expected tumoral uptake (3.21 ± 0.77%ID/g), more than double that in the Pretargeting Group (1.21 ± 0.03%ID/g). Therefore, this work confirmed the signal amplification effect of dendrimer-PNA in vivo. More... »

PAGES

2895-2902

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10967-022-08289-y

DOI

http://dx.doi.org/10.1007/s10967-022-08289-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1147680301


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