Preparation and preclinical evaluation of 68Ga-iPSMA-BN as a potential heterodimeric radiotracer for PET-imaging of prostate cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-10-27

AUTHORS

Mónica Janet Mendoza-Figueroa, Alondra Escudero-Castellanos, Gerardo Julián Ramirez-Nava, Blanca Elí Ocampo-García, Clara Leticia Santos-Cuevas, Guillermina Ferro-Flores, Martha Pedraza-Lopez, Miguel Angel Avila-Rodriguez

ABSTRACT

In this research, we report the labeling and preclinical evaluation of the heterodimer 68Ga-iPSMA-BN ligand regarding its ability to target the prostate-specific membrane antigen (PSMA) and the gastrin-releasing peptide receptor (GRPr) in prostate cancer tumors. A heterodimer conjugate of iPSMA (PSMA inhibitor) (Nal-Lys-CO-Glu-OH) and Lys3-Bombesin (BN) with DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) as chelator was synthesized, labeled with 68Ga and the in vitro PSMA/GRPr affinity assessed. Using pulmonary micrometastasis LNCaP (PSMA+) and PC3 (GRPr+) models, the influence of the ligand heterobivalency and affinity on the tumor uptake was analyzed quantitatively from the micro-PET imaging data, obtaining promising results. More... »

PAGES

2097-2105

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10967-018-6285-3

DOI

http://dx.doi.org/10.1007/s10967-018-6285-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107880679


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