177Lu-DOTA-HYNIC-Lys(Nal)-Urea-Glu: synthesis and assessment of the ability to target the prostate specific membrane antigen View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-10-09

AUTHORS

Tania Hernández-Jiménez, Guillermina Ferro-Flores, Blanca Ocampo-García, Enrique Morales-Avila, Alondra Escudero-Castellanos, Erika Azorín-Vega, Clara Santos-Cuevas, Myrna Luna-Gutiérrez, Nallely Jiménez-Mancilla, Luis Alberto Medina, Flor de Maria Ramirez, Martha Pedraza-López

ABSTRACT

SPECT/CT images have proved the capability of 99mTc-EDDA/HYNIC-Lys(β-naphthylalanine)-NH-CO-NH-Glu to detect prostate cancer tumors in patients. Considering that theranostics combines the potential of therapeutic and diagnostic radionuclides in the same molecular probe, this research aimed to prepare 177Lu-DOTA-HYNIC-Lys(β-naphthylalanine)-NH-CO-NH-Glu (177Lu-iPSMA) and evaluate the in vitro and in vivo radiotracer ability to target the PSMA protein overexpressed in prostate cancer cells (LNCaP). 177Lu-iPSMA, obtained with radiochemical purities of 99%, showed specific in vitro and in vivo recognition for PSMA in prostate cancer cells and high LNCaP-tumor uptake (11 ± 2% ID/g at 24 h). The results obtained warrant further studies to evaluate the therapeutic efficacy of 177Lu-iPSMA. More... »

PAGES

2059-2066

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10967-018-6239-9

DOI

http://dx.doi.org/10.1007/s10967-018-6239-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1107497237


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