Chelator-free radiolabeling of dextran with 68Ga for PET studies View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-03

AUTHORS

Nazila Gholipour, Mehdi Akhlaghi, Amin Mokhtari Kheirabadi, Davood Beiki, Parham Geramifar, Hassan Yousefnia, Mohammad Mazidi

ABSTRACT

The possibility of 68Ga-dextran complex formation was analyzed in an HEPES-buffered (pH = 4.5) as well as in an alkaline (pH = 9) solution. The result outlined that the alkaline solution was more efficient to achieve a radiolabeling efficiency of 99% for a 5 mg ml−1 dextran solution (10 min, 90 °C). 68Ga-dextran was stable 88, 71 and 86% after 2 h at storage and toward cysteine solution and human serum, respectively. The highest ROI derived %ID g−1 was found within the lungs, followed by the blood, liver, and bladder. Furthermore, a significant uptake was observed in the cartilage tissue. 68Ga-dextran excreted more by the urinary and less by the biliary pathways. More... »

PAGES

1811-1817

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10967-016-5164-z

DOI

http://dx.doi.org/10.1007/s10967-016-5164-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018523254


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