Development of 68Ga ethyl cysteinate dimer for PET studies View Full Text


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Article Info

DATE

2016-01

AUTHORS

Alireza Mirzaei, Amir R. Jalilian, Gholamali Shabani, Ashraf Fakhari, Mehdi Akhlaghi, Davood Beiki

ABSTRACT

In this work development of 68Ga-ethyl cysteinate dimer (68Ga-ECD) a 68Ga tracer for possible cerebral blood flow based on 99mTc ECD homolog is reported. 68Ga-ECD was prepared using generator-based 68GaCl3 and ECD at optimized conditions. Quality control, stability, partition co-efficient and the biodistribution of the tracer (by tissue counting and PET/CT in rats) was studied. Significant metabolism of the lipophilic tracer into water soluble metabolite(s) led to urinary excretion of the tracer, un-comparable to that of homologous 99mTc-compound. Cardiac uptake of the complex suggests formation of a possible lipophil cationic complex and/or metabolite. More... »

PAGES

725-732

References to SciGraph publications

  • 1984-11. 99mTc-propylene amine oxime (99mTc-PnAO); a potential brain radiopharmaceutical in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2005-05. Preparation of [66Ga]bleomycin complex as a possible PET radiopharmaceutical in JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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    http://scigraph.springernature.com/pub.10.1007/s10967-015-4185-3

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    http://dx.doi.org/10.1007/s10967-015-4185-3

    DIMENSIONS

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