Preparation of highly purified 68Ga solutions via ion exchange in hydrochloric acid–ethanol mixtures View Full Text


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Article Info

DATE

2015-07

AUTHORS

A. A. Larenkov, A. B. Bruskin, G. E. Kodina

ABSTRACT

The ion-exchange behavior of 68Ga in mixed HCl–ethanol media on cation and anion exchangers was studied. The mass distribution coefficients of 68Ga on Dowex 50 W × 8 and Dowex 1 × 8 ion-exchange resins at HCl concentrations in the range 0.1–3.0 M and with ethanol volume fractions 0–90 % were determined. The dynamic characteristics of the 68Ga ion exchange in mixed HCl–ethanol solutions were studied. A process, based on the data obtained, was developed for preparing of 68Ga solutions in 0.1 M HCl with high chemical and radiochemical purity that are suitable for producing of 68Ga-radiopharmaceuticals with required quality for clinical use. The suitability of the process for the synthesis of different 68Ga-radiopharmaceuticals in routine clinical practice was demonstrated. More... »

PAGES

147-160

References to SciGraph publications

  • 2014-01. Preparation of high-purity 68Ga solutions by ion exchange in mixed acetone-hydrochloric acid medium in RADIOCHEMISTRY
  • 2004-08. 68Ga-labelled DOTA-derivatised peptide ligands in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2013. 68Ga-Radiopharmaceuticals for PET Imaging of Infection and Inflammation in THERANOSTICS, GALLIUM-68, AND OTHER RADIONUCLIDES
  • 2005-04. Radiolabelling DOTA-peptides with 68Ga in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2012-10. Oral Sessions in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10967-015-4089-2

    DOI

    http://dx.doi.org/10.1007/s10967-015-4089-2

    DIMENSIONS

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