Development of an 111In-labeled dihydropyridine complex for L-type calcium channel imaging View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-03

AUTHORS

T. Firouzyar, A. R. Jalilian, M. Shafiee-Ardestani, M. R. Aboudzadeh, Y. Fazaeli, F. Bolourinovin, M. Mirzaii, A. Khalaj

ABSTRACT

[111In]-DTPA-Amlodipine complex ([111In]-DTPA-AMLO) was prepared starting high purity [111In]indium chloride and conjugated DTPA-AMLO in 30 min at room temperature in acetate buffer in high radiochemical purity (>99 %, RTLC/HPLC; specific activity: 8–10 GBq/mmol). The log P, stability, biodistribution studies and imaging studies in untreated and amlodipine-pretreated rats were determined. The tracer is mostly washed out through kidneys as expected for a dihydropyridine compound. Blocking studies demonstrated high specific binding of the tracer in calcium channel-rich organs including intestine, heart and colon. SPECT images fully supported above results in normal and treated rats. More... »

PAGES

2361-2369

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10967-014-3656-2

DOI

http://dx.doi.org/10.1007/s10967-014-3656-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036175032


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